119595

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2727439..2728058 Replicon chromosome
Accession NZ_CP036335
Organism Klebsiella pneumoniae strain BP327

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag EYB55_RS13655 Protein ID WP_002892050.1
Coordinates 2727840..2728058 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag EYB55_RS13650 Protein ID WP_002892066.1
Coordinates 2727439..2727813 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EYB55_RS13640 2722591..2723784 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
EYB55_RS13645 2723807..2726953 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
EYB55_RS13650 2727439..2727813 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
EYB55_RS13655 2727840..2728058 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
EYB55_RS13660 2728221..2728787 + 567 WP_002892030.1 maltose O-acetyltransferase -
EYB55_RS30160 2728759..2728899 - 141 WP_004147370.1 hypothetical protein -
EYB55_RS13665 2728920..2729390 + 471 WP_002892026.1 YlaC family protein -
EYB55_RS13670 2729365..2730816 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
EYB55_RS13675 2730917..2731615 + 699 WP_002892021.1 GNAT family N-acetyltransferase -
EYB55_RS13680 2731612..2731752 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
EYB55_RS13685 2731752..2732015 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T119595 WP_002892050.1 NZ_CP036335:2727840-2728058 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T119595 NZ_CP036335:2727840-2728058 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT119595 WP_002892066.1 NZ_CP036335:2727439-2727813 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT119595 NZ_CP036335:2727439-2727813 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References