Detailed information of TA system TA119580

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4636671..4637187
• Replicon: chromosome
• Accession: NZ_CP036327
• Organism: Klebsiella pneumoniae strain BA28434

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: C3E96_RS23195
• Protein ID: WP_040216106.1
• Coordinates: 4636903..4637187 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: C3E96_RS23190
• Protein ID: WP_064162488.1
• Coordinates: 4636671..4636913 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C3E96_RS23175	4632699..4633439	+	741	WP_002886899.1	KDGP aldolase family protein	-
C3E96_RS23180	4633506..4634660	+	1155	WP_064162489.1	lactonase family protein	-
C3E96_RS23185	4634683..4636593	+	1911	WP_023325426.1	BglG family transcription antiterminator	-
C3E96_RS23190	4636671..4636913	+	243	WP_064162488.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
C3E96_RS23195	4636903..4637187	+	285	WP_040216106.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
C3E96_RS23200	4637191..4637655	-	465	WP_064162487.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
C3E96_RS23205	4637963..4640101	-	2139	WP_004186701.1	anaerobic ribonucleoside-triphosphate reductase	-
C3E96_RS23210	4640458..4641201	-	744	WP_002886905.1	MurR/RpiR family transcriptional regulator	-
C3E96_RS29890	4641204..4641377	-	174	WP_032425422.1	hypothetical protein	-
C3E96_RS23215	4641462..4641770	+	309	WP_012737232.1	PTS sugar transporter subunit IIB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-69)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11097.94 Da
• Isoelectric Point: 10.4962

>T119580 WP_040216106.1 NZ_CP036327:4636903-4637187 [Klebsiella pneumoniae]
MTYELAFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Nucleotide

• Length: 285 bp

>T119580 NZ_CP036327:4636903-4637187 [Klebsiella pneumoniae]
ATGACCTATGAACTGGCGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9059.57 Da
• Isoelectric Point: 6.3340

>AT119580 WP_064162488.1 NZ_CP036327:4636671-4636913 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPLKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Nucleotide

• Length: 243 bp

>AT119580 NZ_CP036327:4636671-4636913 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGTTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA