Detailed information of TA system TA119577

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3282169..3282826
• Replicon: chromosome
• Accession: NZ_CP036327
• Organism: Klebsiella pneumoniae strain BA28434

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: C3E96_RS16410
• Protein ID: WP_040245400.1
• Coordinates: 3282169..3282579 (-)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: W8UQ37
• Locus tag: C3E96_RS16415
• Protein ID: WP_002916312.1
• Coordinates: 3282560..3282826 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C3E96_RS16390	3278169..3279902	-	1734	WP_004149758.1	single-stranded-DNA-specific exonuclease RecJ	-
C3E96_RS16395	3279908..3280621	-	714	WP_048290928.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
C3E96_RS16400	3280644..3281540	-	897	WP_004144729.1	site-specific tyrosine recombinase XerD	-
C3E96_RS16405	3281641..3282162	+	522	WP_002916308.1	flavodoxin FldB	-
C3E96_RS16410	3282169..3282579	-	411	WP_040245400.1	protein YgfX	Toxin
C3E96_RS16415	3282560..3282826	-	267	WP_002916312.1	FAD assembly factor SdhE	Antitoxin
C3E96_RS16420	3283072..3284055	+	984	WP_032430613.1	tRNA-modifying protein YgfZ	-
C3E96_RS16425	3284206..3284865	-	660	WP_048334397.1	hemolysin III family protein	-
C3E96_RS16430	3285029..3285340	-	312	WP_004144734.1	N(4)-acetylcytidine aminohydrolase	-
C3E96_RS16435	3285390..3286118	+	729	WP_002916321.1	MurR/RpiR family transcriptional regulator	-
C3E96_RS16440	3286237..3287670	+	1434	WP_002916322.1	6-phospho-beta-glucosidase BglA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 16035.83 Da
• Isoelectric Point: 11.4778

>T119577 WP_040245400.1 NZ_CP036327:c3282579-3282169 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDSRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Nucleotide

• Length: 411 bp

>T119577 NZ_CP036327:c3282579-3282169 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATAGCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10480.98 Da
• Isoelectric Point: 5.1116

>AT119577 WP_002916312.1 NZ_CP036327:c3282826-3282560 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT119577 NZ_CP036327:c3282826-3282560 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GY41