Detailed information of TA system TA119557

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 2978118..2978775
• Replicon: chromosome
• Accession: NZ_CP036320
• Organism: Klebsiella pneumoniae strain VBA2172

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: CK244_RS14785
• Protein ID: WP_040245400.1
• Coordinates: 2978365..2978775 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: W8UQ37
• Locus tag: CK244_RS14780
• Protein ID: WP_002916312.1
• Coordinates: 2978118..2978384 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CK244_RS14755	2973274..2974707	-	1434	WP_002916322.1	6-phospho-beta-glucosidase BglA	-
CK244_RS14760	2974826..2975554	-	729	WP_002916321.1	MurR/RpiR family transcriptional regulator	-
CK244_RS14765	2975604..2975915	+	312	WP_004144734.1	N(4)-acetylcytidine aminohydrolase	-
CK244_RS14770	2976079..2976738	+	660	WP_048334397.1	hemolysin III family protein	-
CK244_RS14775	2976889..2977872	-	984	WP_032430613.1	tRNA-modifying protein YgfZ	-
CK244_RS14780	2978118..2978384	+	267	WP_002916312.1	FAD assembly factor SdhE	Antitoxin
CK244_RS14785	2978365..2978775	+	411	WP_040245400.1	protein YgfX	Toxin
CK244_RS14790	2978782..2979303	-	522	WP_002916308.1	flavodoxin FldB	-
CK244_RS14795	2979404..2980300	+	897	WP_004144729.1	site-specific tyrosine recombinase XerD	-
CK244_RS14800	2980323..2981036	+	714	WP_048290928.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
CK244_RS14805	2981042..2982775	+	1734	WP_004149758.1	single-stranded-DNA-specific exonuclease RecJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 16035.83 Da
• Isoelectric Point: 11.4778

>T119557 WP_040245400.1 NZ_CP036320:2978365-2978775 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDSRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Nucleotide

• Length: 411 bp

>T119557 NZ_CP036320:2978365-2978775 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATAGCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10480.98 Da
• Isoelectric Point: 5.1116

>AT119557 WP_002916312.1 NZ_CP036320:2978118-2978384 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT119557 NZ_CP036320:2978118-2978384 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GY41