Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1621204..1621720 Replicon chromosome
Accession NZ_CP036320
Organism Klebsiella pneumoniae strain VBA2172

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag CK244_RS07985 Protein ID WP_040216106.1
Coordinates 1621204..1621488 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag CK244_RS07990 Protein ID WP_064162488.1
Coordinates 1621478..1621720 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CK244_RS07965 1616621..1616929 - 309 WP_012737232.1 PTS sugar transporter subunit IIB -
CK244_RS28580 1617014..1617187 + 174 WP_032425422.1 hypothetical protein -
CK244_RS07970 1617190..1617933 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
CK244_RS07975 1618290..1620428 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
CK244_RS07980 1620736..1621200 + 465 WP_064162487.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
CK244_RS07985 1621204..1621488 - 285 WP_040216106.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CK244_RS07990 1621478..1621720 - 243 WP_064162488.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
CK244_RS07995 1621798..1623708 - 1911 WP_023325426.1 BglG family transcription antiterminator -
CK244_RS08000 1623731..1624885 - 1155 WP_064162489.1 lactonase family protein -
CK244_RS08005 1624952..1625692 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-69)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11097.94 Da        Isoelectric Point: 10.4962

>T119554 WP_040216106.1 NZ_CP036320:c1621488-1621204 [Klebsiella pneumoniae]
MTYELAFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T119554 NZ_CP036320:c1621488-1621204 [Klebsiella pneumoniae]
ATGACCTATGAACTGGCGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9059.57 Da        Isoelectric Point: 6.3340

>AT119554 WP_064162488.1 NZ_CP036320:c1621720-1621478 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPLKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT119554 NZ_CP036320:c1621720-1621478 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGTTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References