Detailed information of TA system TA119550

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 4431240..4431847
• Replicon: chromosome
• Accession: NZ_CP036310
• Organism: Enterobacter hormaechei strain WCHEH090011

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A4Q4AAS0
• Locus tag: EKN58_RS21825
• Protein ID: WP_057979982.1
• Coordinates: 4431662..4431847 (-)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: EKN58_RS21820
• Protein ID: WP_023315016.1
• Coordinates: 4431240..4431647 (-)
• Length: 136 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EKN58_RS21805	4427983..4429236	+	1254	WP_015572749.1	valine--pyruvate transaminase	-
EKN58_RS21810	4429244..4429699	-	456	WP_023323869.1	4Fe-4S dicluster domain-containing protein	-
EKN58_RS21815	4430160..4431236	+	1077	WP_023323870.1	type I restriction enzyme HsdR N-terminal domain-containing protein	-
EKN58_RS21820	4431240..4431647	-	408	WP_023315016.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
EKN58_RS21825	4431662..4431847	-	186	WP_057979982.1	type II toxin-antitoxin system HicA family toxin	Toxin
EKN58_RS21830	4432097..4433635	-	1539	WP_006808612.1	aldehyde dehydrogenase AldB	-
EKN58_RS21835	4433802..4434686	+	885	WP_003860164.1	ROK family protein	-
EKN58_RS21840	4434690..4436528	-	1839	WP_023323871.1	selenocysteine-specific translation elongation factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-129)

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 6852.08 Da
• Isoelectric Point: 11.5191

>T119550 WP_057979982.1 NZ_CP036310:c4431847-4431662 [Enterobacter hormaechei]
VKSADIITVLVSHGWKCVRTKGSHHQFRHPVQKGLVTVPHPKKDIKPGTLAQIWRQAGIKH

Nucleotide

• Length: 186 bp

>T119550 NZ_CP036310:c4431847-4431662 [Enterobacter hormaechei]
GTGAAAAGTGCGGATATCATTACTGTTCTGGTTAGCCATGGCTGGAAATGTGTAAGAACGAAGGGAAGCCATCATCAGTT
TCGCCATCCAGTGCAAAAAGGGTTGGTTACCGTCCCACATCCTAAAAAGGACATTAAACCAGGCACTCTCGCACAAATCT
GGCGACAGGCGGGAATTAAACACTGA

Antitoxin

Protein

• Length: 136 a.a.
• Molecular weight: 15205.20 Da
• Isoelectric Point: 4.5036

>AT119550 WP_023315016.1 NZ_CP036310:c4431647-4431240 [Enterobacter hormaechei]
MFYPAYIHSDSDGSASGFFPDVPGCFFAGDSLDDAFQDARDALTAHFEALFEMDEMLPLPGMVEAHLASHPEDFIGGQWL
LVDINMKQFEGRVERINITIPRRLLVKIDSFVSEHPQFTNRSAFLAEAARRVLPR

Nucleotide

• Length: 408 bp

>AT119550 NZ_CP036310:c4431647-4431240 [Enterobacter hormaechei]
ATGTTTTATCCGGCTTACATTCATTCTGATTCCGACGGTAGCGCCAGTGGTTTCTTTCCTGACGTTCCGGGGTGTTTTTT
TGCGGGGGATTCACTGGATGATGCTTTTCAGGATGCACGTGATGCATTAACTGCCCATTTTGAAGCGTTGTTTGAAATGG
ATGAAATGTTGCCACTTCCGGGTATGGTTGAAGCGCATCTGGCAAGTCATCCGGAGGATTTCATTGGCGGACAATGGTTG
CTGGTGGATATCAATATGAAACAGTTTGAAGGCAGAGTAGAGCGCATCAATATTACGATACCTCGCCGTTTGCTGGTGAA
GATTGATTCCTTTGTCAGCGAGCATCCACAATTTACTAACCGAAGTGCTTTTCTTGCAGAGGCAGCACGGCGTGTACTGC
CCCGGTGA

Structures

Toxin

• AlphaFold DB: A0A4Q4AAS0