Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 832155..832812 Replicon chromosome
Accession NZ_CP036310
Organism Enterobacter hormaechei strain WCHEH090011

Toxin (Protein)


Gene name cptA Uniprot ID A0A0A6GSQ9
Locus tag EKN58_RS04150 Protein ID WP_022649305.1
Coordinates 832402..832812 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag EKN58_RS04145 Protein ID WP_003863437.1
Coordinates 832155..832421 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EKN58_RS04125 827587..829020 - 1434 WP_003863430.1 6-phospho-beta-glucosidase BglA -
EKN58_RS04130 829137..829868 - 732 WP_023314798.1 MurR/RpiR family transcriptional regulator -
EKN58_RS04135 830135..830794 + 660 WP_003863433.1 hemolysin III family protein -
EKN58_RS04140 830880..831860 - 981 WP_022649306.1 tRNA-modifying protein YgfZ -
EKN58_RS04145 832155..832421 + 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
EKN58_RS04150 832402..832812 + 411 WP_022649305.1 protein YgfX Toxin
EKN58_RS04155 832814..833335 - 522 WP_003863440.1 flavodoxin FldB -
EKN58_RS04160 833437..834333 + 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
EKN58_RS04165 834362..835075 + 714 WP_003863443.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
EKN58_RS04170 835081..836814 + 1734 WP_032610082.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T119538 WP_022649305.1 NZ_CP036310:832402-832812 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAAMVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMIGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T119538 NZ_CP036310:832402-832812 [Enterobacter hormaechei]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCACAGTGGATGTCCTTACTGCTCCACGGTCTGGTCGCGGC
AATGGTGTTATTGGTGCCGTGGCCGCTAAGCTATACCCCTCTGTGGCTGCTTTTGCTGTCGTTTGTGGTGTTTGATAGCG
TGCGCAGCCAGCGTCGAATCAACGCCCGTCAGGGTGAAATTAAGCTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAAATGATAGGGACGCCGTGGATGCTCAACACCGGGATGATGCTACGGCTGCGTCGGGTCGAGGATAACCGTCG
CCAGCACCTGTGGCTGGCCGCAGACAGTATGGATCCCGCGGAGTGGCGGGATCTGCGCCGGCTAATCGTGCAACAGCCAA
CGCAGGAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT119538 WP_003863437.1 NZ_CP036310:832155-832421 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT119538 NZ_CP036310:832155-832421 [Enterobacter hormaechei]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6GSQ9

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References