Detailed information of TA system TA119474

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PP_4151-4152/excise(antitoxin)
• Location: 5141364..5142311
• Replicon: chromosome
• Accession: NZ_CP036292
• Organism: Rosistilla oblonga strain CA51

Toxin (Protein)

• Gene name: PP_4152
• Uniprot ID: -
• Locus tag: CA51_RS18190
• Protein ID: WP_197451852.1
• Coordinates: 5141763..5142311 (+)
• Length: 183 a.a.

Antitoxin (Protein)

• Gene name: PP_4151
• Uniprot ID: -
• Locus tag: CA51_RS18185
• Protein ID: WP_197451281.1
• Coordinates: 5141364..5141738 (+)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CA51_RS18165	5137592..5138644	-	1053	WP_145122637.1	hypothetical protein	-
CA51_RS18170	5138732..5139085	-	354	WP_145122638.1	DUF952 domain-containing protein	-
CA51_RS18175	5139089..5140327	-	1239	WP_197451280.1	amidohydrolase family protein	-
CA51_RS18180	5140336..5140995	+	660	WP_145124237.1	DNA-3-methyladenine glycosylase	-
CA51_RS18185	5141364..5141738	+	375	WP_197451281.1	helix-turn-helix domain-containing protein	Antitoxin
CA51_RS18190	5141763..5142311	+	549	WP_197451852.1	PIN domain-containing protein	Toxin
CA51_RS18195	5142529..5143788	-	1260	WP_197451282.1	PQQ-binding-like beta-propeller repeat protein	-
CA51_RS18200	5143998..5145002	+	1005	WP_145099078.1	sugar phosphate isomerase/epimerase	-
CA51_RS18205	5144975..5145382	-	408	WP_145122641.1	hypothetical protein	-
CA51_RS25930	5145381..5145602	+	222	WP_197451283.1	hypothetical protein	-
CA51_RS18210	5145717..5146577	+	861	WP_197451284.1	carbohydrate kinase	-
CA51_RS18215	5146561..5147235	+	675	WP_145122643.1	ceramidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-106)

Antitoxin

• SinI-like, DNA-binding domain (54-101)

Sequences

Toxin

Protein

• Length: 183 a.a.
• Molecular weight: 20783.89 Da
• Isoelectric Point: 6.2276

>T119474 WP_197451852.1 NZ_CP036292:5141763-5142311 [Rosistilla oblonga]
MDACVLYPAPLRDLLLSLAASGIYRAKWSQKIHDEWTHNLLLKRPDLDAERLRRTCVQMNLAVPDSLVTEYEALIDSLHL
KDPDDRHVLAVAIRCNADSIVTFNQKDFDEAELKKYGLYTEHPDEFISNMLEVYAPNVLAAVREMRARLKNPPVEVAGFL
ETLRRQGLPQTVHILSRYASSL

Nucleotide

• Length: 549 bp

>T119474 NZ_CP036292:5141763-5142311 [Rosistilla oblonga]
TTGGATGCCTGCGTCTTGTACCCGGCTCCACTTCGCGATTTGCTACTCAGCCTCGCAGCGTCGGGGATATATCGCGCGAA
GTGGTCGCAGAAAATTCACGATGAATGGACGCACAATCTGCTGCTGAAACGCCCCGACCTGGATGCCGAAAGATTACGAC
GAACGTGCGTGCAAATGAATCTGGCAGTTCCCGACAGTTTGGTGACGGAATACGAAGCCTTAATCGATTCGCTCCACCTC
AAAGATCCCGATGACCGGCATGTTCTTGCCGTTGCGATCCGCTGCAACGCCGATTCGATCGTCACCTTCAACCAGAAGGA
TTTTGATGAGGCGGAGCTAAAGAAATATGGTTTGTATACGGAGCACCCAGACGAATTCATTTCTAACATGCTCGAAGTCT
ACGCCCCCAACGTCCTTGCCGCAGTCCGCGAAATGCGCGCTCGCCTGAAGAACCCACCAGTCGAAGTGGCGGGATTTCTA
GAAACACTCCGGCGCCAAGGCTTGCCACAAACCGTGCATATATTGTCTCGATACGCAAGCTCGCTTTAG

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 13699.79 Da
• Isoelectric Point: 7.9990

>AT119474 WP_197451281.1 NZ_CP036292:5141364-5141738 [Rosistilla oblonga]
VARDIDPTSVITIQSTGDGRSIEVPKNVFDVLVKTLAIMAEGKAFSLIPVDKELTTQQAADILNVSRPFLSKVLDLGEIP
HRKVGRNRRVKFCDLIEYKKKQEQSSKAALQSLADEAQELGMGY

Nucleotide

• Length: 375 bp

>AT119474 NZ_CP036292:5141364-5141738 [Rosistilla oblonga]
GTGGCCCGCGACATCGACCCCACCTCGGTCATAACGATCCAATCAACCGGAGACGGCCGGTCGATCGAGGTGCCCAAAAA
CGTATTCGATGTTTTGGTGAAAACCCTTGCGATCATGGCGGAAGGAAAGGCGTTCTCCTTGATCCCGGTCGACAAGGAAT
TAACCACTCAACAGGCGGCGGATATCTTGAACGTTTCACGCCCCTTCCTGAGCAAGGTGCTCGACTTGGGCGAGATTCCG
CATCGTAAGGTCGGTAGAAATCGCCGGGTCAAATTCTGCGATCTGATCGAATACAAAAAGAAGCAGGAACAGTCGAGCAA
AGCGGCATTGCAGTCTCTGGCCGATGAAGCACAGGAACTTGGCATGGGGTACTAG