Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-Phd
Location 5575418..5576076 Replicon chromosome
Accession NZ_CP036291
Organism Pirellulimonas nuda strain Pla175

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag Pla175_RS21650 Protein ID WP_145290536.1
Coordinates 5575657..5576076 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapC Uniprot ID -
Locus tag Pla175_RS21645 Protein ID WP_145290532.1
Coordinates 5575418..5575660 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Pla175_RS21625 5570990..5571379 + 390 WP_145290522.1 hypothetical protein -
Pla175_RS21630 5571697..5572179 + 483 WP_145290525.1 hypothetical protein -
Pla175_RS21635 5572377..5573795 - 1419 WP_197527055.1 type I glutamate--ammonia ligase -
Pla175_RS21640 5574060..5575049 + 990 WP_145290528.1 serine/threonine protein kinase -
Pla175_RS21645 5575418..5575660 + 243 WP_145290532.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
Pla175_RS21650 5575657..5576076 + 420 WP_145290536.1 type II toxin-antitoxin system VapC family toxin Toxin
Pla175_RS21655 5576167..5576496 + 330 WP_145290541.1 hypothetical protein -
Pla175_RS21660 5577043..5578587 + 1545 WP_197527056.1 sulfatase -
Pla175_RS21665 5579081..5579524 + 444 WP_145290547.1 hypothetical protein -
Pla175_RS21670 5579457..5580587 + 1131 WP_145284379.1 ISAs1 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 5579457..5580587 1130


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-122)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-64)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14949.16 Da        Isoelectric Point: 7.2064

>T119473 WP_145290536.1 NZ_CP036291:5575657-5576076 [Pirellulimonas nuda]
VKVLLDTNVVSEARKPRGNPGVRRRLAELDEFNQFLSVVSIGEIAYGVARLARGKLRDALELWLAQAERSFADRLLPVDA
QVAGLWGELAARSAAAGGTISLADGLIAATAIHHGMRLMTRNVADFASTGGMLINPWEE

Download         Length: 420 bp

>T119473 NZ_CP036291:5575657-5576076 [Pirellulimonas nuda]
GTGAAGGTGTTGCTCGATACGAATGTCGTCTCCGAAGCACGCAAGCCGCGCGGGAACCCCGGCGTACGCAGGCGGCTGGC
AGAGCTGGACGAATTCAATCAGTTCTTAAGCGTGGTCTCGATTGGCGAGATCGCTTACGGCGTGGCGCGGCTTGCCCGCG
GCAAACTCCGCGATGCCCTCGAGCTCTGGCTCGCCCAAGCAGAACGGAGTTTCGCAGACAGGCTCCTCCCGGTCGATGCC
CAGGTCGCCGGGCTCTGGGGCGAACTGGCAGCGCGATCCGCGGCGGCCGGTGGCACGATCTCGCTGGCCGATGGGCTGAT
CGCCGCCACCGCCATCCACCACGGCATGAGGTTGATGACCCGCAACGTGGCGGATTTTGCGTCGACGGGGGGGATGCTGA
TCAACCCGTGGGAGGAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9092.36 Da        Isoelectric Point: 4.6283

>AT119473 WP_145290532.1 NZ_CP036291:5575418-5575660 [Pirellulimonas nuda]
MEWKLAEAKNKLSELVTRATSEGPQTIRRNGVGVIVVAEETYLELTGQRPSFKQWLLEGPRIDDLELPSRDPSPMREVDL

Download         Length: 243 bp

>AT119473 NZ_CP036291:5575418-5575660 [Pirellulimonas nuda]
ATGGAATGGAAATTAGCCGAGGCCAAGAATAAGCTCAGCGAGCTTGTGACCCGGGCCACGTCCGAAGGGCCTCAAACGAT
TCGGCGAAACGGGGTGGGCGTAATCGTTGTGGCGGAAGAGACGTACTTGGAGCTGACCGGACAGCGTCCCAGTTTCAAGC
AGTGGCTGCTGGAAGGCCCCCGCATCGACGACCTAGAGTTGCCGAGCCGCGACCCATCGCCGATGCGAGAGGTCGACCTG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References