Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicA
Location 4414588..4414988 Replicon chromosome
Accession NZ_CP036291
Organism Pirellulimonas nuda strain Pla175

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag Pla175_RS17160 Protein ID WP_145287867.1
Coordinates 4414588..4414776 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag Pla175_RS17165 Protein ID WP_145287870.1
Coordinates 4414773..4414988 (+) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Pla175_RS17135 4410328..4411716 + 1389 WP_145287850.1 30S ribosomal protein S12 methylthiotransferase RimO -
Pla175_RS17140 4411836..4412408 + 573 WP_197526929.1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase -
Pla175_RS17145 4412408..4413376 + 969 WP_145287857.1 CPBP family intramembrane metalloprotease -
Pla175_RS17150 4413478..4413693 + 216 WP_145287860.1 type II toxin-antitoxin system HicB family antitoxin -
Pla175_RS26155 4413772..4414383 - 612 WP_197526930.1 hypothetical protein -
Pla175_RS17160 4414588..4414776 + 189 WP_145287867.1 type II toxin-antitoxin system HicA family toxin Toxin
Pla175_RS17165 4414773..4414988 + 216 WP_145287870.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
Pla175_RS17170 4415015..4416079 - 1065 WP_145287873.1 Gfo/Idh/MocA family oxidoreductase -
Pla175_RS17175 4416076..4416882 - 807 WP_145287876.1 acyl-ACP--UDP-N-acetylglucosamine O-acyltransferase -
Pla175_RS17180 4417056..4417928 - 873 WP_145287880.1 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase -
Pla175_RS17185 4418044..4418655 - 612 WP_145287883.1 OmpH family outer membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-60)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-61)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7037.13 Da        Isoelectric Point: 11.3242

>T119472 WP_145287867.1 NZ_CP036291:4414588-4414776 [Pirellulimonas nuda]
MKVAEILDRLDQDGWRLVAYRGSHRQFKHPTKTGRVTVPGKRNDDLPPGTLNSILKQAGLKR

Download         Length: 189 bp

>T119472 NZ_CP036291:4414588-4414776 [Pirellulimonas nuda]
ATGAAGGTTGCAGAAATCCTGGATCGTCTTGACCAGGATGGCTGGCGCCTGGTCGCTTACCGAGGCAGCCACCGCCAATT
CAAGCACCCCACGAAGACCGGGCGCGTAACTGTTCCGGGCAAACGCAACGACGACCTGCCTCCCGGGACGCTCAATAGCA
TCCTCAAACAAGCCGGACTCAAGCGATGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7904.91 Da        Isoelectric Point: 4.2080

>AT119472 WP_145287870.1 NZ_CP036291:4414773-4414988 [Pirellulimonas nuda]
MKRYAIVIEKAPNNFAAYVPDLPGCVATGATFEETEREVREAIEFHLEGLREDGLPIPEPVTRVDYSEVPG

Download         Length: 216 bp

>AT119472 NZ_CP036291:4414773-4414988 [Pirellulimonas nuda]
ATGAAACGCTACGCGATTGTCATCGAGAAGGCCCCAAACAATTTTGCGGCCTACGTGCCGGACCTGCCAGGCTGCGTGGC
AACCGGGGCGACCTTCGAAGAGACCGAGCGCGAGGTCCGCGAAGCGATCGAGTTCCACCTAGAGGGGCTGCGAGAGGACG
GACTGCCGATCCCAGAACCGGTGACGCGAGTCGACTACTCAGAAGTCCCGGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References