Detailed information of TA system TA119472

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicA
• Location: 4414588..4414988
• Replicon: chromosome
• Accession: NZ_CP036291
• Organism: Pirellulimonas nuda strain Pla175

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: Pla175_RS17160
• Protein ID: WP_145287867.1
• Coordinates: 4414588..4414776 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: Pla175_RS17165
• Protein ID: WP_145287870.1
• Coordinates: 4414773..4414988 (+)
• Length: 72 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Pla175_RS17135	4410328..4411716	+	1389	WP_145287850.1	30S ribosomal protein S12 methylthiotransferase RimO	-
Pla175_RS17140	4411836..4412408	+	573	WP_197526929.1	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase	-
Pla175_RS17145	4412408..4413376	+	969	WP_145287857.1	CPBP family intramembrane metalloprotease	-
Pla175_RS17150	4413478..4413693	+	216	WP_145287860.1	type II toxin-antitoxin system HicB family antitoxin	-
Pla175_RS26155	4413772..4414383	-	612	WP_197526930.1	hypothetical protein	-
Pla175_RS17160	4414588..4414776	+	189	WP_145287867.1	type II toxin-antitoxin system HicA family toxin	Toxin
Pla175_RS17165	4414773..4414988	+	216	WP_145287870.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
Pla175_RS17170	4415015..4416079	-	1065	WP_145287873.1	Gfo/Idh/MocA family oxidoreductase	-
Pla175_RS17175	4416076..4416882	-	807	WP_145287876.1	acyl-ACP--UDP-N-acetylglucosamine O-acyltransferase	-
Pla175_RS17180	4417056..4417928	-	873	WP_145287880.1	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	-
Pla175_RS17185	4418044..4418655	-	612	WP_145287883.1	OmpH family outer membrane protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-60)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-61)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7037.13 Da
• Isoelectric Point: 11.3242

>T119472 WP_145287867.1 NZ_CP036291:4414588-4414776 [Pirellulimonas nuda]
MKVAEILDRLDQDGWRLVAYRGSHRQFKHPTKTGRVTVPGKRNDDLPPGTLNSILKQAGLKR

Nucleotide

• Length: 189 bp

>T119472 NZ_CP036291:4414588-4414776 [Pirellulimonas nuda]
ATGAAGGTTGCAGAAATCCTGGATCGTCTTGACCAGGATGGCTGGCGCCTGGTCGCTTACCGAGGCAGCCACCGCCAATT
CAAGCACCCCACGAAGACCGGGCGCGTAACTGTTCCGGGCAAACGCAACGACGACCTGCCTCCCGGGACGCTCAATAGCA
TCCTCAAACAAGCCGGACTCAAGCGATGA

Antitoxin

Protein

• Length: 72 a.a.
• Molecular weight: 7904.91 Da
• Isoelectric Point: 4.2080

>AT119472 WP_145287870.1 NZ_CP036291:4414773-4414988 [Pirellulimonas nuda]
MKRYAIVIEKAPNNFAAYVPDLPGCVATGATFEETEREVREAIEFHLEGLREDGLPIPEPVTRVDYSEVPG

Nucleotide

• Length: 216 bp

>AT119472 NZ_CP036291:4414773-4414988 [Pirellulimonas nuda]
ATGAAACGCTACGCGATTGTCATCGAGAAGGCCCCAAACAATTTTGCGGCCTACGTGCCGGACCTGCCAGGCTGCGTGGC
AACCGGGGCGACCTTCGAAGAGACCGAGCGCGAGGTCCGCGAAGCGATCGAGTTCCACCTAGAGGGGCTGCGAGAGGACG
GACTGCCGATCCCAGAACCGGTGACGCGAGTCGACTACTCAGAAGTCCCGGGCTGA