Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicA
Location 4414588..4414988 Replicon chromosome
Accession NZ_CP036291
Organism Pirellulimonas nuda strain Pla175

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag Pla175_RS17160 Protein ID WP_145287867.1
Coordinates 4414588..4414776 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag Pla175_RS17165 Protein ID WP_145287870.1
Coordinates 4414773..4414988 (+) Length 72 a.a.

Genomic Context

Pla175_RS17135Pla175_RS17140Pla175_RS17145Pla175_RS17150Pla175_RS17160Pla175_RS17165Pla175_RS26155Pla175_RS17170Pla175_RS17175Pla175_RS17180Pla175_RS17185
Location: 4410328..4411716 (1389 bp)
Type: Others
Protein ID: WP_145287850.1
Location: 4411836..4412408 (573 bp)
Type: Others
Protein ID: WP_197526929.1
Location: 4412408..4413376 (969 bp)
Type: Others
Protein ID: WP_145287857.1
Location: 4413478..4413693 (216 bp)
Type: Others
Protein ID: WP_145287860.1
Location: 4414588..4414776 (189 bp)
Type: Toxin
Protein ID: WP_145287867.1
Location: 4414773..4414988 (216 bp)
Type: Antitoxin
Protein ID: WP_145287870.1
Location: 4413772..4414383 (612 bp)
Type: Others
Protein ID: WP_197526930.1
Location: 4415015..4416079 (1065 bp)
Type: Others
Protein ID: WP_145287873.1
Location: 4416076..4416882 (807 bp)
Type: Others
Protein ID: WP_145287876.1
Location: 4417056..4417928 (873 bp)
Type: Others
Protein ID: WP_145287880.1
Location: 4418044..4418655 (612 bp)
Type: Others
Protein ID: WP_145287883.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
Pla175_RS171354410328..4411716+1389WP_145287850.130S ribosomal protein S12 methylthiotransferase RimO-
Pla175_RS171404411836..4412408+573WP_197526929.1CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase-
Pla175_RS171454412408..4413376+969WP_145287857.1CPBP family intramembrane metalloprotease-
Pla175_RS171504413478..4413693+216WP_145287860.1type II toxin-antitoxin system HicB family antitoxin-
Pla175_RS261554413772..4414383-612WP_197526930.1hypothetical protein-
Pla175_RS171604414588..4414776+189WP_145287867.1type II toxin-antitoxin system HicA family toxinToxin
Pla175_RS171654414773..4414988+216WP_145287870.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
Pla175_RS171704415015..4416079-1065WP_145287873.1Gfo/Idh/MocA family oxidoreductase-
Pla175_RS171754416076..4416882-807WP_145287876.1acyl-ACP--UDP-N-acetylglucosamine O-acyltransferase-
Pla175_RS171804417056..4417928-873WP_145287880.1UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase-
Pla175_RS171854418044..4418655-612WP_145287883.1OmpH family outer membrane protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-60)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-61)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7037.13 Da        Isoelectric Point: 11.3242

>T119472 WP_145287867.1 NZ_CP036291:4414588-4414776 [Pirellulimonas nuda]
MKVAEILDRLDQDGWRLVAYRGSHRQFKHPTKTGRVTVPGKRNDDLPPGTLNSILKQAGLKR

Download         Length: 189 bp

>T119472 NZ_CP036291:4414588-4414776 [Pirellulimonas nuda]
ATGAAGGTTGCAGAAATCCTGGATCGTCTTGACCAGGATGGCTGGCGCCTGGTCGCTTACCGAGGCAGCCACCGCCAATT
CAAGCACCCCACGAAGACCGGGCGCGTAACTGTTCCGGGCAAACGCAACGACGACCTGCCTCCCGGGACGCTCAATAGCA
TCCTCAAACAAGCCGGACTCAAGCGATGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7904.91 Da        Isoelectric Point: 4.2080

>AT119472 WP_145287870.1 NZ_CP036291:4414773-4414988 [Pirellulimonas nuda]
MKRYAIVIEKAPNNFAAYVPDLPGCVATGATFEETEREVREAIEFHLEGLREDGLPIPEPVTRVDYSEVPG

Download         Length: 216 bp

>AT119472 NZ_CP036291:4414773-4414988 [Pirellulimonas nuda]
ATGAAACGCTACGCGATTGTCATCGAGAAGGCCCCAAACAATTTTGCGGCCTACGTGCCGGACCTGCCAGGCTGCGTGGC
AACCGGGGCGACCTTCGAAGAGACCGAGCGCGAGGTCCGCGAAGCGATCGAGTTCCACCTAGAGGGGCTGCGAGAGGACG
GACTGCCGATCCCAGAACCGGTGACGCGAGTCGACTACTCAGAAGTCCCGGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References