Detailed information of TA system TA119471

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 786805..787160
• Replicon: chromosome
• Accession: NZ_CP036291
• Organism: Pirellulimonas nuda strain Pla175

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: Pla175_RS03255
• Protein ID: WP_197527493.1
• Coordinates: 786805..786936 (+)
• Length: 44 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: Pla175_RS03260
• Protein ID: WP_145281264.1
• Coordinates: 786945..787160 (+)
• Length: 72 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Pla175_RS03235	782849..783145	-	297	WP_197527492.1	bleomycin resistance protein	-
Pla175_RS03240	783294..783542	-	249	WP_145281261.1	hypothetical protein	-
Pla175_RS03245	783596..784210	-	615	WP_145281262.1	exopolysaccharide biosynthesis protein	-
Pla175_RS03250	784361..786319	-	1959	WP_145291970.1	DNA topoisomerase VI subunit B	-
Pla175_RS03255	786805..786936	+	132	WP_197527493.1	type II toxin-antitoxin system HicA family toxin	Toxin
Pla175_RS03260	786945..787160	+	216	WP_145281264.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
Pla175_RS03265	787411..787839	+	429	WP_145281265.1	hypothetical protein	-
Pla175_RS03270	787905..788267	+	363	WP_145281266.1	hypothetical protein	-
Pla175_RS03275	788450..790549	-	2100	WP_145281267.1	hypothetical protein	-
Pla175_RS03280	790552..790995	-	444	WP_145281268.1	biopolymer transporter ExbD	-
Pla175_RS03285	791124..791348	-	225	WP_145281269.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	783294..818075	34781

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (2-41)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-65)

Sequences

Toxin

Protein

• Length: 44 a.a.
• Molecular weight: 4538.29 Da
• Isoelectric Point: 11.8222

>T119471 WP_197527493.1 NZ_CP036291:786805-786936 [Pirellulimonas nuda]
MRGSHRQFVHATKPGTVTVSGKPNVDIPVGTLKSILKQAGLNP

Nucleotide

• Length: 132 bp

>T119471 NZ_CP036291:786805-786936 [Pirellulimonas nuda]
ATGCGGGGCAGTCACCGGCAATTTGTGCACGCGACCAAGCCCGGCACTGTCACGGTGTCCGGCAAGCCGAATGTTGATAT
CCCAGTTGGCACGCTGAAGAGTATACTTAAGCAAGCTGGACTGAACCCATAA

Antitoxin

Protein

• Length: 72 a.a.
• Molecular weight: 7547.45 Da
• Isoelectric Point: 3.9638

>AT119471 WP_145281264.1 NZ_CP036291:786945-787160 [Pirellulimonas nuda]
MKYTVIIEQGENSWGAYVPDLPGCIAAADTREGAIALIREAIEFHIEGLAEQGEPVPAPHSSSELVEINAA

Nucleotide

• Length: 216 bp

>AT119471 NZ_CP036291:786945-787160 [Pirellulimonas nuda]
ATGAAGTACACGGTGATTATCGAGCAGGGCGAGAATAGCTGGGGCGCTTACGTTCCGGACCTTCCCGGCTGTATCGCTGC
CGCAGACACCCGCGAGGGAGCGATTGCGCTGATCCGCGAGGCGATCGAGTTCCACATCGAGGGTCTAGCCGAGCAGGGTG
AGCCGGTCCCTGCGCCCCACTCATCGAGCGAGCTGGTCGAGATTAACGCCGCGTAG