Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2564838..2566383 Replicon chromosome
Accession NZ_CP036282
Organism Rhodoferax sediminis strain Gr-4

Toxin (Protein)


Gene name HipA1 Uniprot ID -
Locus tag EXZ61_RS11745 Protein ID WP_142811950.1
Coordinates 2565088..2566383 (+) Length 432 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID -
Locus tag EXZ61_RS11740 Protein ID WP_142811949.1
Coordinates 2564838..2565098 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EXZ61_RS11725 2561049..2562089 - 1041 WP_142811947.1 LacI family DNA-binding transcriptional regulator -
EXZ61_RS11730 2562243..2563433 - 1191 WP_142814215.1 acyl-CoA dehydrogenase -
EXZ61_RS11735 2563647..2564549 + 903 WP_142811948.1 LysR family transcriptional regulator -
EXZ61_RS11740 2564838..2565098 + 261 WP_142811949.1 helix-turn-helix transcriptional regulator Antitoxin
EXZ61_RS11745 2565088..2566383 + 1296 WP_142811950.1 type II toxin-antitoxin system HipA family toxin Toxin
EXZ61_RS11750 2566682..2568592 - 1911 WP_142811951.1 acyl-CoA dehydrogenase C-terminal domain-containing protein -
EXZ61_RS11755 2568596..2569888 - 1293 WP_142811952.1 acetyl-CoA C-acetyltransferase -
EXZ61_RS11760 2569940..2570824 - 885 WP_142811953.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(147-377)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-65)


Sequences

Toxin        


Download         Length: 432 a.a.        Molecular weight: 47458.35 Da        Isoelectric Point: 7.4601

>T119470 WP_142811950.1 NZ_CP036282:2565088-2566383 [Rhodoferax sediminis]
MAHELEVWLFANRVGTLALADGRLSFCYASSWLAQADALALSVSLPLQATPFDDRTTRPFFAGLLPEGRMRQLIAQQFQV
SSQNDFALLDHIGGDCAGAVTFLAPGQALPIPPRNEDVQWLSDDEVLTILDELPRRPMLAGKDGLRLSLAGAQDKLPVVF
DGARIGLPRNGTPSSHILKPAIHAVEDSVTNEGFCMALAEAMQLKPAKSIVHRVRGRAFLLVERYDRLIDTQGKRQRLHQ
EDFCQALGVVPEMKYQNEGGPDLAQCFNLVRSATRPSAPQTLRLLDYVVFNALIGNHDAHAKNFSLLYAGKAPVLAPFYD
TLSTAVYPSLTPKMAMKIGSKYKFSEVQARHWEQFAESAGLTKAQAKRRIRELAHSLPGVARKLQSDRERGFAGNAVVEQ
INALMEQRCALTIRRLTDPDAENDATAEPPV

Download         Length: 1296 bp

>T119470 NZ_CP036282:2565088-2566383 [Rhodoferax sediminis]
ATGGCGCATGAGTTAGAAGTCTGGCTTTTTGCCAATCGGGTCGGCACCTTGGCGCTGGCCGATGGTCGCTTGAGTTTTTG
CTACGCATCCAGCTGGCTGGCGCAAGCAGATGCCCTTGCCTTATCCGTGTCGCTGCCCCTGCAAGCGACGCCATTTGACG
ACCGCACAACGCGTCCCTTCTTTGCCGGGCTTCTGCCAGAGGGGCGCATGCGCCAGCTGATTGCGCAACAGTTCCAAGTT
TCTAGCCAGAACGACTTCGCGCTGTTAGACCACATTGGCGGCGATTGCGCAGGGGCCGTGACCTTTCTTGCACCGGGCCA
AGCGCTACCCATCCCGCCCCGCAACGAGGATGTTCAATGGCTTAGTGACGACGAGGTCCTAACCATCCTGGATGAACTGC
CGCGCCGCCCCATGCTAGCTGGCAAAGACGGATTGCGGCTTTCATTGGCTGGCGCACAAGACAAACTGCCGGTTGTGTTT
GATGGGGCCCGCATTGGGCTACCGCGCAATGGCACACCCAGTTCCCACATCTTGAAGCCTGCTATCCACGCGGTGGAAGA
CAGTGTGACCAACGAAGGATTTTGCATGGCGCTGGCTGAGGCCATGCAACTCAAGCCGGCGAAATCGATTGTTCACCGAG
TGCGGGGTCGCGCGTTCCTGCTGGTGGAGCGATACGACCGACTGATAGATACCCAAGGTAAGCGGCAACGCCTTCACCAA
GAAGACTTTTGCCAAGCGCTGGGCGTGGTACCGGAGATGAAATACCAAAACGAAGGTGGGCCCGATCTGGCGCAGTGTTT
CAACTTGGTACGCAGCGCAACGCGCCCCAGTGCACCGCAAACCTTGCGCCTGCTCGACTACGTAGTTTTCAATGCGCTGA
TCGGCAACCACGACGCGCACGCCAAGAACTTCTCGCTGCTGTACGCAGGCAAAGCACCCGTACTGGCACCCTTCTACGAC
ACGCTGTCAACGGCTGTGTACCCAAGCTTGACACCGAAGATGGCGATGAAAATCGGCAGCAAGTACAAATTCAGCGAGGT
TCAGGCGCGGCACTGGGAGCAATTTGCAGAAAGCGCCGGCCTCACCAAAGCGCAGGCGAAAAGGCGCATACGGGAGTTGG
CCCATTCATTGCCAGGCGTGGCGCGCAAGCTCCAGTCCGACCGTGAACGAGGCTTTGCTGGCAACGCAGTGGTTGAGCAA
ATCAACGCATTAATGGAACAACGTTGCGCTTTGACCATTCGGCGGCTCACCGACCCCGATGCAGAAAATGACGCGACTGC
AGAGCCCCCGGTCTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 8941.28 Da        Isoelectric Point: 7.0082

>AT119470 WP_142811949.1 NZ_CP036282:2564838-2565098 [Rhodoferax sediminis]
MTSIQSPQQLGNALRAARKQLGLTQPQLALAAGVGVRFMVDLEAGKPTLRLENVLRVIAALGGEIQLSGLPAAVTDDQQA
VNDHGA

Download         Length: 261 bp

>AT119470 NZ_CP036282:2564838-2565098 [Rhodoferax sediminis]
ATGACATCCATTCAATCGCCTCAACAATTAGGAAATGCCTTGCGTGCCGCGCGCAAGCAGCTGGGCCTGACACAGCCTCA
GCTAGCTCTCGCGGCAGGGGTCGGTGTGCGCTTCATGGTCGACCTAGAAGCAGGCAAGCCCACCTTGCGCTTGGAAAACG
TGCTGCGTGTCATTGCTGCCTTGGGCGGCGAGATTCAGTTGAGCGGGTTGCCAGCAGCAGTGACCGACGATCAACAGGCA
GTTAATGACCATGGCGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References