119466

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pmenTA/darT(toxin)
Location 3453924..3455649 Replicon chromosome
Accession NZ_CP036280
Organism Mucisphaera calidilacus strain Pan265

Toxin (Protein)


Gene name pmenT Uniprot ID -
Locus tag Pan265_RS14395 Protein ID WP_236254491.1
Coordinates 3454981..3455649 (-) Length 223 a.a.

Antitoxin (Protein)


Gene name pmenA Uniprot ID -
Locus tag Pan265_RS14390 Protein ID WP_145447138.1
Coordinates 3453924..3454979 (-) Length 352 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Pan265_RS14375 (Pan265_28710) 3449575..3450855 - 1281 WP_145447135.1 N-acetylmuramoyl-L-alanine amidase -
Pan265_RS14380 (Pan265_28720) 3450941..3452323 + 1383 WP_236254490.1 family 10 glycosylhydrolase -
Pan265_RS14385 (Pan265_28730) 3452566..3453570 - 1005 WP_145447137.1 uroporphyrinogen decarboxylase family protein -
Pan265_RS14390 (Pan265_28740) 3453924..3454979 - 1056 WP_145447138.1 macro domain-containing protein Antitoxin
Pan265_RS14395 (Pan265_28750) 3454981..3455649 - 669 WP_236254491.1 DUF4433 domain-containing protein Toxin
Pan265_RS14400 (Pan265_28760) 3455852..3456349 - 498 WP_145447139.1 GNAT family N-acetyltransferase -
Pan265_RS14405 (Pan265_28770) 3456412..3457971 - 1560 WP_236254492.1 family 10 glycosylhydrolase -
Pan265_RS14410 (Pan265_28780) 3458100..3459470 + 1371 WP_145447141.1 MFS transporter -
Pan265_RS14415 (Pan265_28790) 3459465..3460091 - 627 WP_145447142.1 SAM-dependent methyltransferase -
Pan265_RS14420 (Pan265_28800) 3460110..3460643 + 534 WP_145447143.1 topology modulation protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

ssDNA thymidine ADP-ribosyltransferase, DarT

(22-222)

Antitoxin

Macro domain

(18-130)


Sequences

Toxin        


Download         Length: 223 a.a.        Molecular weight: 25588.13 Da        Isoelectric Point: 6.4904

>T119466 WP_236254491.1 NZ_CP036280:c3455649-3454981 [Mucisphaera calidilacus]
MLEARWCRTEMAGLNAKDGRIFRITHVNNVPWLLDNGLHCMNSPKQDLNFVPIGSQELILKRSSHTVEAEPRGTLADYIP
FYFTPYSVMMYNIKTGYHGVIQRPNHEIVILTSSVHRLAELKIPFVFYDGHAYMQESTCYNSVDDLDKIDWPLLQAKDFR
RDPERPEKFNRYQAEALAYRHVPIDALLGIACYNESTTEQIANDTANASLNLAVKTLPSWYF

Download         Length: 669 bp

>T119466 NZ_CP036280:c3455649-3454981 [Mucisphaera calidilacus]
ATGCTGGAAGCGAGATGGTGCCGAACTGAAATGGCAGGCCTGAACGCAAAAGATGGGAGAATATTTCGCATTACGCACGT
CAATAACGTGCCATGGCTTCTGGATAACGGTCTGCACTGCATGAATAGCCCAAAGCAAGATTTGAACTTCGTGCCCATCG
GCAGTCAGGAGTTAATCCTCAAACGGTCAAGCCACACGGTAGAAGCCGAACCGAGGGGGACGCTCGCAGACTACATACCG
TTCTATTTCACGCCTTACTCAGTCATGATGTACAACATCAAAACCGGATACCATGGCGTAATCCAGCGTCCGAATCACGA
GATCGTGATCCTCACCTCTTCCGTGCACCGATTAGCCGAGCTCAAAATCCCCTTCGTCTTCTACGACGGCCACGCATACA
TGCAGGAAAGCACCTGCTACAACTCTGTCGATGATCTCGACAAGATCGATTGGCCACTGCTTCAGGCAAAAGACTTCAGA
CGAGACCCAGAACGCCCTGAGAAATTCAACCGCTATCAGGCCGAAGCGCTCGCATACCGCCACGTACCCATCGATGCCCT
ACTCGGTATTGCGTGCTACAATGAGTCAACCACCGAACAGATTGCAAACGACACCGCAAACGCCAGCTTGAATCTAGCCG
TTAAAACATTGCCATCATGGTACTTCTGA

Antitoxin


Download         Length: 352 a.a.        Molecular weight: 39696.78 Da        Isoelectric Point: 7.5320

>AT119466 WP_145447138.1 NZ_CP036280:c3454979-3453924 [Mucisphaera calidilacus]
MIHYTSGNLLEADTEALVNTVNTVGVMGKGIALMFKDRFPDIFNAYKTACDRNEVLTGKMFVTQTGQLHNPKWVIHFPTK
KHWRPPSKIEWIDQGLADLRQVILDLNIKSIGIPPLGSGNGKLDWADVRPLIEQHLSDLQNVRILVYEPSQAYRNVSKTT
GLEELTPPRAMIAEMIRRYEILGLDCSILEIQKLAWVLNRVINQMGLKNPLKLDFTAQKYGPYSNNLRHLLDKLDGSYLH
CEKRLADSTPLDTIHFAPSHDQKLRAFLQGGEKKHWVEAIDAADAFIDGFQSPLGMEALATVGWLIDAEKCEPTLQSIRE
GIAHWPYSADAAQRKQAMFSDKLLLAAIRRY

Download         Length: 1056 bp

>AT119466 NZ_CP036280:c3454979-3453924 [Mucisphaera calidilacus]
ATGATTCACTACACCTCAGGCAATCTGCTGGAAGCCGACACCGAGGCACTTGTCAACACCGTCAACACCGTCGGCGTCAT
GGGCAAGGGCATCGCCCTGATGTTTAAGGACAGATTCCCCGACATCTTCAACGCCTACAAGACGGCCTGCGACCGCAACG
AGGTTCTAACGGGCAAGATGTTCGTCACGCAAACCGGACAACTACACAACCCAAAGTGGGTGATTCACTTCCCGACTAAG
AAACACTGGCGTCCACCCTCAAAAATCGAATGGATTGATCAGGGGCTTGCCGACCTGCGCCAAGTCATCCTCGACCTGAA
CATCAAATCCATTGGTATCCCACCGCTTGGCAGTGGCAACGGCAAACTCGATTGGGCCGACGTGCGACCGCTCATCGAAC
AACACCTAAGCGATCTCCAGAACGTCAGAATTCTGGTCTATGAACCCAGCCAAGCTTACCGTAATGTCAGCAAAACTACA
GGTCTTGAAGAACTGACACCACCCCGTGCGATGATCGCAGAGATGATCCGTCGCTACGAGATACTTGGGCTCGACTGCTC
AATACTCGAAATCCAGAAACTGGCTTGGGTGCTTAACCGTGTGATCAATCAGATGGGGCTCAAGAATCCCCTGAAACTCG
ACTTCACCGCTCAGAAATACGGCCCCTACTCCAACAATCTCCGACATCTCTTGGACAAACTCGACGGCAGCTACCTGCAC
TGCGAGAAACGTCTTGCGGACTCAACCCCGTTGGACACCATCCACTTCGCTCCTTCACACGACCAGAAGCTCAGAGCCTT
CCTTCAGGGCGGCGAGAAGAAGCACTGGGTCGAAGCCATTGATGCTGCAGATGCTTTCATCGACGGTTTCCAGTCACCTC
TTGGCATGGAAGCACTGGCTACCGTTGGTTGGCTGATCGACGCAGAGAAATGCGAGCCCACTTTGCAAAGCATCCGAGAG
GGAATCGCCCACTGGCCCTACAGTGCAGATGCCGCGCAACGCAAACAAGCTATGTTTAGCGACAAACTTCTACTGGCGGC
TATTAGACGCTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References