Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazE-MazF
Location 1145942..1146498 Replicon chromosome
Accession NZ_CP036280
Organism Mucisphaera calidilacus strain Pan265

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag Pan265_RS04495 Protein ID WP_145445199.1
Coordinates 1145942..1146181 (+) Length 80 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag Pan265_RS04500 Protein ID WP_236254678.1
Coordinates 1146178..1146498 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Pan265_RS04485 (Pan265_09010) 1141557..1142969 - 1413 WP_145445197.1 DNA modification methylase -
Pan265_RS04490 (Pan265_09020) 1143293..1145845 - 2553 WP_145445198.1 DUF3987 domain-containing protein -
Pan265_RS04495 (Pan265_09030) 1145942..1146181 + 240 WP_145445199.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Toxin
Pan265_RS04500 (Pan265_09040) 1146178..1146498 + 321 WP_236254678.1 type II toxin-antitoxin system PemK/MazF family toxin Antitoxin
Pan265_RS04505 (Pan265_09050) 1146510..1148216 - 1707 WP_145445201.1 DEAD/DEAH box helicase -
Pan265_RS04510 (Pan265_09060) 1148216..1148596 - 381 WP_236254814.1 RusA family crossover junction endodeoxyribonuclease -
Pan265_RS04515 (Pan265_09070) 1148613..1149086 - 474 WP_145445203.1 DUF669 domain-containing protein -
Pan265_RS04520 (Pan265_09080) 1149090..1149386 - 297 WP_145445204.1 hypothetical protein -
Pan265_RS04525 (Pan265_09090) 1149390..1150127 - 738 WP_145445205.1 ATP-binding protein -
Pan265_RS04530 (Pan265_09100) 1150325..1151131 - 807 WP_236254679.1 PD-(D/E)XK nuclease-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1120546..1169520 48974


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

SpoVT-AbrB domain

(6-45)

Antitoxin

mRNA interferase PemK-like

(5-104)


Sequences

Toxin        


Download         Length: 80 a.a.        Molecular weight: 8400.33 Da        Isoelectric Point: 4.5436

>T119464 WP_145445199.1 NZ_CP036280:1145942-1146181 [Mucisphaera calidilacus]
MQVSLVKIGNSRGVRLPKRVIEAAGLKDELDLEVRDGAVIVRNAQAARSGWAQAAAACHAAGEDDLRDWDAAADDGDWS

Download         Length: 240 bp

>T119464 NZ_CP036280:1145942-1146181 [Mucisphaera calidilacus]
ATGCAAGTCAGTCTGGTGAAAATCGGGAATTCTCGCGGCGTTCGCCTGCCCAAGCGGGTGATCGAGGCCGCCGGTCTCAA
GGACGAACTGGACTTGGAGGTCCGCGACGGGGCGGTCATCGTGCGCAACGCCCAGGCCGCTCGCAGCGGGTGGGCCCAGG
CGGCGGCGGCGTGCCACGCGGCCGGTGAAGATGACCTGCGCGACTGGGACGCGGCCGCCGATGACGGTGACTGGTCGTGA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 11589.55 Da        Isoelectric Point: 10.9925

>AT119464 WP_236254678.1 NZ_CP036280:1146178-1146498 [Mucisphaera calidilacus]
VKAGQGQVWRVNLDPTIGSEIRKTRPAVVVSPDELNAHLNTVVVVPLTSGRAYPFRIATKVQGKPGVAAVDQVRTIDKQR
LVKRIKTLKAGELNPILDALVEMFSH

Download         Length: 321 bp

>AT119464 NZ_CP036280:1146178-1146498 [Mucisphaera calidilacus]
GTGAAGGCCGGCCAGGGGCAAGTGTGGCGGGTCAACCTCGACCCGACGATCGGCAGCGAGATCCGCAAGACTCGGCCGGC
CGTGGTCGTATCGCCCGATGAACTCAATGCGCATCTGAACACCGTGGTCGTTGTACCCCTGACCAGCGGGCGGGCTTATC
CGTTTCGCATCGCGACGAAGGTGCAGGGCAAGCCCGGTGTCGCGGCGGTCGATCAGGTGCGCACCATCGACAAGCAGCGG
CTGGTCAAGCGGATCAAGACGCTCAAGGCCGGCGAATTGAATCCCATTCTTGACGCTTTGGTCGAGATGTTTAGCCACTA
A

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References