Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | pezAT/ParD(antitoxin) |
| Location | 2552647..2553645 | Replicon | chromosome |
| Accession | NZ_CP036220 | ||
| Organism | Mycobacterium avium subsp. hominissuis strain mc2 2500 | ||
Toxin (Protein)
| Gene name | pezT | Uniprot ID | X7VT18 |
| Locus tag | EX350_RS11955 | Protein ID | WP_003876749.1 |
| Coordinates | 2553067..2553645 (+) | Length | 193 a.a. |
Antitoxin (Protein)
| Gene name | pezA | Uniprot ID | X7VRE0 |
| Locus tag | EX350_RS11950 | Protein ID | WP_033710872.1 |
| Coordinates | 2552647..2553036 (+) | Length | 130 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EX350_RS11930 | 2547782..2548462 | - | 681 | WP_179944035.1 | hypothetical protein | - |
| EX350_RS11935 | 2548542..2550059 | + | 1518 | WP_011724808.1 | carboxylesterase/lipase family protein | - |
| EX350_RS11940 | 2550078..2552075 | + | 1998 | WP_033710859.1 | phosphotransferase | - |
| EX350_RS11945 | 2552072..2552566 | + | 495 | WP_033710858.1 | gluconokinase | - |
| EX350_RS11950 | 2552647..2553036 | + | 390 | WP_033710872.1 | hypothetical protein | Antitoxin |
| EX350_RS11955 | 2553067..2553645 | + | 579 | WP_003876749.1 | zeta toxin family protein | Toxin |
| EX350_RS11960 | 2553650..2554717 | - | 1068 | WP_050593662.1 | DoxX family membrane protein | - |
| EX350_RS11965 | 2554828..2555388 | + | 561 | WP_155267635.1 | pyrazinamidase PncA | - |
| EX350_RS11970 | 2555388..2556188 | + | 801 | WP_033710856.1 | nuclear transport factor 2 family protein | - |
| EX350_RS11975 | 2556202..2556552 | - | 351 | WP_003878038.1 | DoxX family protein | - |
| EX350_RS11980 | 2556721..2557653 | + | 933 | WP_033710855.1 | sigma-70 family RNA polymerase sigma factor | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 193 a.a. Molecular weight: 21034.18 Da Isoelectric Point: 10.6678
>T119378 WP_003876749.1 NZ_CP036220:2553067-2553645 [Mycobacterium avium subsp. hominissuis]
MERLDVVVGPNGAGKSTFIALTLAPLLPGSVVVNADEIARQRWPQDPASHAYDAAKVAADTRAKLIDLGRSFIAETVFSH
PSKLDLLHAARRAGFTVVLHVLLIPEDLAVERVRHRVRAGGHDVPETKIRERHRRLWTPVAEAMTLADLATGYDNSRLRG
PRVVARLSGGLTVGAVDWPAWAPETLRSRWPV
MERLDVVVGPNGAGKSTFIALTLAPLLPGSVVVNADEIARQRWPQDPASHAYDAAKVAADTRAKLIDLGRSFIAETVFSH
PSKLDLLHAARRAGFTVVLHVLLIPEDLAVERVRHRVRAGGHDVPETKIRERHRRLWTPVAEAMTLADLATGYDNSRLRG
PRVVARLSGGLTVGAVDWPAWAPETLRSRWPV
Download Length: 579 bp
>T119378 NZ_CP036220:2553067-2553645 [Mycobacterium avium subsp. hominissuis]
ATGGAGCGACTCGACGTGGTGGTCGGGCCCAACGGCGCCGGCAAGTCGACGTTCATCGCGTTGACCCTGGCGCCGCTGCT
GCCGGGCAGCGTGGTGGTCAACGCCGACGAGATAGCGCGGCAGCGCTGGCCGCAGGATCCGGCGTCGCACGCCTACGACG
CCGCGAAGGTCGCCGCCGACACCCGGGCGAAGCTGATCGACCTGGGCCGGTCGTTCATCGCCGAGACCGTGTTCTCCCAC
CCGTCCAAGCTGGACCTGCTGCACGCCGCCCGCCGCGCCGGCTTCACCGTCGTGCTGCACGTGCTGCTCATCCCGGAAGA
CCTTGCCGTCGAACGGGTCCGGCACCGCGTGCGGGCCGGCGGCCATGACGTGCCGGAAACCAAGATCCGCGAGCGGCATC
GCCGGTTGTGGACTCCGGTCGCCGAGGCGATGACCCTGGCCGACCTGGCCACCGGCTACGACAACAGCCGGCTGCGCGGG
CCGCGTGTGGTGGCCCGGCTCAGCGGCGGGCTGACGGTCGGTGCCGTCGACTGGCCGGCGTGGGCACCCGAGACCTTGCG
GTCGCGTTGGCCGGTCTAA
ATGGAGCGACTCGACGTGGTGGTCGGGCCCAACGGCGCCGGCAAGTCGACGTTCATCGCGTTGACCCTGGCGCCGCTGCT
GCCGGGCAGCGTGGTGGTCAACGCCGACGAGATAGCGCGGCAGCGCTGGCCGCAGGATCCGGCGTCGCACGCCTACGACG
CCGCGAAGGTCGCCGCCGACACCCGGGCGAAGCTGATCGACCTGGGCCGGTCGTTCATCGCCGAGACCGTGTTCTCCCAC
CCGTCCAAGCTGGACCTGCTGCACGCCGCCCGCCGCGCCGGCTTCACCGTCGTGCTGCACGTGCTGCTCATCCCGGAAGA
CCTTGCCGTCGAACGGGTCCGGCACCGCGTGCGGGCCGGCGGCCATGACGTGCCGGAAACCAAGATCCGCGAGCGGCATC
GCCGGTTGTGGACTCCGGTCGCCGAGGCGATGACCCTGGCCGACCTGGCCACCGGCTACGACAACAGCCGGCTGCGCGGG
CCGCGTGTGGTGGCCCGGCTCAGCGGCGGGCTGACGGTCGGTGCCGTCGACTGGCCGGCGTGGGCACCCGAGACCTTGCG
GTCGCGTTGGCCGGTCTAA
Antitoxin
Download Length: 130 a.a. Molecular weight: 13612.07 Da Isoelectric Point: 5.6717
>AT119378 WP_033710872.1 NZ_CP036220:2552647-2553036 [Mycobacterium avium subsp. hominissuis]
MAEAVDRVTRVASDLMDSAAAEGARQSRSAKQQLDHWARVGRAVSSQHTASRRRVEAALAGRLSTAELTLEEGVVFNAEI
SAAIDESLARTNYGATLAGQGVTTVALNDDGEIVEHRPDGTAVVLAGRR
MAEAVDRVTRVASDLMDSAAAEGARQSRSAKQQLDHWARVGRAVSSQHTASRRRVEAALAGRLSTAELTLEEGVVFNAEI
SAAIDESLARTNYGATLAGQGVTTVALNDDGEIVEHRPDGTAVVLAGRR
Download Length: 390 bp
>AT119378 NZ_CP036220:2552647-2553036 [Mycobacterium avium subsp. hominissuis]
ATGGCCGAGGCCGTCGATCGGGTCACCCGGGTCGCGTCCGATCTGATGGACAGCGCGGCGGCCGAGGGCGCCCGTCAGAG
CCGCTCGGCCAAGCAGCAGCTCGACCACTGGGCGCGGGTCGGGCGTGCGGTGTCCAGCCAGCACACCGCGTCCCGGCGGC
GGGTCGAAGCCGCGCTGGCCGGCCGGCTGTCCACCGCCGAACTCACCCTCGAAGAGGGCGTAGTGTTCAACGCCGAGATC
TCGGCGGCCATCGACGAAAGCCTGGCGCGCACCAACTACGGGGCGACGCTGGCCGGGCAGGGTGTCACCACGGTGGCCCT
CAACGACGACGGCGAGATCGTCGAGCACCGGCCCGACGGCACCGCGGTGGTGCTGGCCGGCCGGCGCTGA
ATGGCCGAGGCCGTCGATCGGGTCACCCGGGTCGCGTCCGATCTGATGGACAGCGCGGCGGCCGAGGGCGCCCGTCAGAG
CCGCTCGGCCAAGCAGCAGCTCGACCACTGGGCGCGGGTCGGGCGTGCGGTGTCCAGCCAGCACACCGCGTCCCGGCGGC
GGGTCGAAGCCGCGCTGGCCGGCCGGCTGTCCACCGCCGAACTCACCCTCGAAGAGGGCGTAGTGTTCAACGCCGAGATC
TCGGCGGCCATCGACGAAAGCCTGGCGCGCACCAACTACGGGGCGACGCTGGCCGGGCAGGGTGTCACCACGGTGGCCCT
CAACGACGACGGCGAGATCGTCGAGCACCGGCCCGACGGCACCGCGGTGGTGCTGGCCGGCCGGCGCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E2W6B4 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | X7VRE0 |