Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-PHD
Location 2210117..2210781 Replicon chromosome
Accession NZ_CP036220
Organism Mycobacterium avium subsp. hominissuis strain mc2 2500

Toxin (Protein)


Gene name vapC Uniprot ID A0A2A2ZII2
Locus tag EX350_RS10490 Protein ID WP_023861453.1
Coordinates 2210374..2210781 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A2A2ZI58
Locus tag EX350_RS10485 Protein ID WP_033719712.1
Coordinates 2210117..2210377 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EX350_RS10465 2205535..2206197 + 663 WP_023861449.1 TetR/AcrR family transcriptional regulator -
EX350_RS10470 2206392..2207852 + 1461 WP_033719709.1 serine/threonine protein kinase -
EX350_RS10475 2208050..2209318 - 1269 WP_033719710.1 cytochrome P450 -
EX350_RS10480 2209484..2209936 + 453 WP_033719711.1 VOC family protein -
EX350_RS10485 2210117..2210377 + 261 WP_033719712.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EX350_RS10490 2210374..2210781 + 408 WP_023861453.1 type II toxin-antitoxin system VapC family toxin Toxin
EX350_RS10495 2210928..2212492 - 1565 Protein_2064 serine/threonine protein kinase -
EX350_RS10500 2212729..2213250 + 522 WP_033719714.1 carboxymuconolactone decarboxylase family protein -
EX350_RS10505 2213247..2213792 + 546 WP_033719715.1 carboxymuconolactone decarboxylase family protein -
EX350_RS10510 2213913..2214443 + 531 WP_019734505.1 TetR/AcrR family transcriptional regulator -
EX350_RS10515 2214432..2215601 - 1170 WP_033719716.1 acyl-CoA dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-125)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-64)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14414.44 Da        Isoelectric Point: 4.5860

>T119377 WP_023861453.1 NZ_CP036220:2210374-2210781 [Mycobacterium avium subsp. hominissuis]
MTARPAAGVLDTSVFIASESGRHLDEARIPDEVATTVITLAELHAGVLAATTSDVRAQRLATLESIADMEMLPVDDDAAR
MWARLRIHLAEAGRRMRANDLWIAAIAASRGLPVVTQDDDFAALDGAANLAIIRV

Download         Length: 408 bp

>T119377 NZ_CP036220:2210374-2210781 [Mycobacterium avium subsp. hominissuis]
ATGACTGCAAGGCCGGCGGCCGGGGTGCTCGACACCTCGGTGTTCATCGCGTCCGAAAGCGGACGGCACCTGGACGAGGC
GCGAATCCCCGACGAGGTAGCCACCACCGTCATCACCCTTGCCGAACTTCACGCCGGCGTATTAGCCGCGACGACGTCCG
ACGTTCGGGCGCAACGCCTCGCAACGCTGGAATCGATAGCGGATATGGAAATGTTGCCAGTCGACGACGACGCAGCCCGC
ATGTGGGCAAGGTTGCGGATCCACCTAGCCGAGGCTGGACGGCGGATGCGGGCTAATGATCTGTGGATCGCGGCGATCGC
GGCATCGCGGGGACTGCCCGTCGTCACCCAGGATGACGACTTCGCCGCACTCGACGGCGCGGCGAACCTGGCGATTATTC
GGGTCTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9608.98 Da        Isoelectric Point: 11.7137

>AT119377 WP_033719712.1 NZ_CP036220:2210117-2210377 [Mycobacterium avium subsp. hominissuis]
MSEVASRELRNDTAGVLRRVREGEDVTITINGRAVAMLTALRPQRRRWLSKAELLSRLRRAQADPGLRQDLATLAGDTTE
DLGPIR

Download         Length: 261 bp

>AT119377 NZ_CP036220:2210117-2210377 [Mycobacterium avium subsp. hominissuis]
ATGTCTGAAGTGGCGTCTCGCGAGCTGCGCAACGATACGGCGGGGGTACTGCGGCGCGTGCGGGAAGGGGAGGACGTCAC
CATCACCATCAACGGCCGAGCCGTCGCGATGCTGACCGCGCTGCGGCCGCAGCGACGGCGGTGGCTGAGCAAGGCGGAGT
TGCTGTCGCGCTTGCGCCGCGCGCAAGCCGATCCCGGGCTACGCCAAGACCTCGCAACCCTTGCAGGCGACACCACTGAG
GACCTCGGTCCGATCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2ZII2

Antitoxin

Source ID Structure
AlphaFold DB A0A2A2ZI58

References