Detailed information of TA system TA119376

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 1403012..1403576
• Replicon: chromosome
• Accession: NZ_CP036220
• Organism: Mycobacterium avium subsp. hominissuis strain mc2 2500

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A2A2ZLT9
• Locus tag: EX350_RS06935
• Protein ID: WP_023868517.1
• Coordinates: 1403205..1403576 (+)
• Length: 124 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: EX350_RS06930
• Protein ID: WP_011724021.1
• Coordinates: 1403012..1403218 (+)
• Length: 69 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EX350_RS06910	1398266..1399264	+	999	WP_023868514.1	4-hydroxy-3-methylbut-2-enyl diphosphate reductase	-
EX350_RS06915	1399288..1400496	-	1209	WP_179151735.1	hypothetical protein	-
EX350_RS06920	1400627..1401700	+	1074	WP_009975391.1	redox-regulated ATPase YchF	-
EX350_RS06925	1401900..1402844	+	945	WP_033720356.1	HNH endonuclease	-
EX350_RS06930	1403012..1403218	+	207	WP_011724021.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
EX350_RS06935	1403205..1403576	+	372	WP_023868517.1	type II toxin-antitoxin system VapC family toxin	Toxin
EX350_RS06940	1403676..1404116	+	441	WP_003875392.1	nitroreductase family deazaflavin-dependent oxidoreductase	-
EX350_RS06945	1404174..1404449	+	276	WP_033718665.1	hypothetical protein	-
EX350_RS06950	1404551..1404949	+	399	WP_023865349.1	VOC family protein	-
EX350_RS06955	1405018..1405401	+	384	WP_023868520.1	hypothetical protein	-
EX350_RS06960	1405471..1405824	+	354	WP_023868521.1	hypothetical protein	-
EX350_RS06965	1405981..1406529	+	549	WP_080516335.1	glycoside hydrolase	-
EX350_RS06970	1406932..1407255	+	324	WP_009975396.1	antibiotic biosynthesis monooxygenase	-
EX350_RS06975	1407260..1407943	-	684	WP_009975397.1	hypothetical protein	-
EX350_RS06980	1408061..1408258	+	198	WP_009975398.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-112)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (1-42)

Sequences

Toxin

Protein

• Length: 124 a.a.
• Molecular weight: 13754.08 Da
• Isoelectric Point: 6.6032

>T119376 WP_023868517.1 NZ_CP036220:1403205-1403576 [Mycobacterium avium subsp. hominissuis]
MILVDTSVWIDHLHVADKRLIEFLTNDAIGCHQMVIEELALGAIRRRADLLRLLSNLRAFPLLTHAEVLHLVESHRLWGR
GLSAIDVHLLGSVALVDGARLWTRDKNLKAAGWDVGIAIVDEL

Nucleotide

• Length: 372 bp

>T119376 NZ_CP036220:1403205-1403576 [Mycobacterium avium subsp. hominissuis]
ATGATTCTCGTTGACACGTCGGTATGGATCGATCATCTGCACGTCGCCGACAAGCGACTCATAGAGTTCCTGACCAACGA
CGCAATCGGTTGCCACCAAATGGTGATCGAGGAGTTGGCATTGGGTGCGATCAGGCGGCGCGCCGATCTATTGCGCCTGC
TGTCCAATCTTCGGGCGTTCCCGTTGCTGACGCATGCGGAGGTCCTTCATCTCGTCGAAAGCCACCGCTTGTGGGGCCGC
GGACTGAGTGCGATCGACGTCCATCTTCTTGGGTCGGTTGCTCTGGTCGACGGTGCACGGCTATGGACCAGGGACAAGAA
TTTAAAAGCGGCGGGCTGGGACGTGGGTATCGCGATCGTCGACGAGCTCTGA

Antitoxin

Protein

• Length: 69 a.a.
• Molecular weight: 7261.25 Da
• Isoelectric Point: 11.0634

>AT119376 WP_011724021.1 NZ_CP036220:1403012-1403218 [Mycobacterium avium subsp. hominissuis]
MRTTVTIDDALLAEAAELTGVTESVALLRQGLQTLVRVESARRLAALGGTDRKASVGPRRRTPADDSR

Nucleotide

• Length: 207 bp

>AT119376 NZ_CP036220:1403012-1403218 [Mycobacterium avium subsp. hominissuis]
ATGAGGACGACGGTGACGATTGACGACGCCTTATTGGCAGAGGCGGCCGAACTGACCGGGGTGACAGAGAGCGTGGCGCT
CCTCCGTCAGGGACTGCAGACACTCGTTCGGGTAGAGAGCGCCCGTCGGCTGGCGGCGCTCGGCGGCACGGATCGGAAGG
CATCGGTCGGCCCTCGCCGGAGGACACCCGCCGATGATTCTCGTTGA

Structures

Toxin

• AlphaFold DB: A0A2A2ZLT9