Detailed information of TA system TA119375

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): unclassified/Polyketide_cyc2(toxin)
• Location: 1178373..1179026
• Replicon: chromosome
• Accession: NZ_CP036220
• Organism: Mycobacterium avium subsp. hominissuis strain mc2 2500

Toxin (Protein)

• Gene name: novel[antitoxin]
• Uniprot ID: -
• Locus tag: EX350_RS05885
• Protein ID: WP_003872880.1
• Coordinates: 1178565..1179026 (+)
• Length: 154 a.a.

Antitoxin (Protein)

• Gene name: novel[toxin]
• Uniprot ID: Q742J1
• Locus tag: EX350_RS05880
• Protein ID: WP_003872881.1
• Coordinates: 1178373..1178561 (+)
• Length: 63 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EX350_RS05870	1174355..1175941	+	1587	WP_023900196.1	serine hydrolase	-
EX350_RS05875	1175938..1178310	+	2373	WP_088295086.1	cation-translocating P-type ATPase	-
EX350_RS05880	1178373..1178561	+	189	WP_003872881.1	antitoxin	Antitoxin
EX350_RS05885	1178565..1179026	+	462	WP_003872880.1	SRPBCC family protein	Toxin
EX350_RS05890	1179096..1179530	+	435	WP_023880080.1	hypothetical protein	-
EX350_RS05895	1180529..1182112	+	1584	WP_003872878.1	DUF4185 domain-containing protein	-
EX350_RS05900	1182159..1182545	+	387	WP_033720314.1	hypothetical protein	-
EX350_RS05905	1183332..1183670	+	339	WP_009975166.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Polyketide cyclase/dehydrase (2-142)

Antitoxin

• Antitoxin Rv0909/MT0933 (4-51)

Sequences

Toxin

Protein

• Length: 154 a.a.
• Molecular weight: 16626.19 Da
• Isoelectric Point: 9.5654

>T119375 WP_003872880.1 NZ_CP036220:1178565-1179026 [Mycobacterium avium subsp. hominissuis]
VAKLSGSIDVPLPPEVAWQHASDLSRYKEWLTIHRVWRSTLPDQIDKGTVVESIVEVKGMLNRIKWTVVRYKPPEGMTLN
GDGVGGVKVKLMAKVQPKADGSVVSFDVHLGGPALFGPIGMIVAAALRGDIDQSLENFVTVFARSDPSTNGHR

Nucleotide

• Length: 462 bp

>T119375 NZ_CP036220:1178565-1179026 [Mycobacterium avium subsp. hominissuis]
GTGGCCAAGCTTTCCGGATCCATCGATGTTCCGCTGCCCCCCGAGGTGGCCTGGCAGCACGCCTCCGACCTGTCCCGGTA
CAAGGAGTGGCTGACCATTCACCGGGTGTGGCGCAGCACCTTGCCCGACCAGATCGACAAGGGCACCGTCGTCGAGTCGA
TCGTCGAGGTCAAGGGCATGCTCAACCGGATCAAATGGACGGTGGTGCGCTACAAGCCACCGGAGGGCATGACGCTCAAC
GGCGACGGCGTCGGCGGGGTCAAGGTCAAGCTGATGGCCAAGGTGCAGCCCAAGGCGGACGGCTCGGTCGTCAGCTTCGA
CGTGCACCTCGGCGGTCCGGCGCTGTTCGGGCCAATCGGCATGATCGTCGCGGCCGCGCTGCGCGGCGACATCGACCAGT
CGCTGGAGAACTTCGTCACGGTGTTCGCCCGATCGGATCCGAGCACCAACGGTCATCGCTGA

Antitoxin

Protein

• Length: 63 a.a.
• Molecular weight: 6745.42 Da
• Isoelectric Point: 4.4865

>AT119375 WP_003872881.1 NZ_CP036220:1178373-1178561 [Mycobacterium avium subsp. hominissuis]
MGFLDKAKDLLSQNADKVEMAIDKAGEFVDEKTQGKYSDTIHQVQEQAKKATGATETGDQQG

Nucleotide

• Length: 189 bp

>AT119375 NZ_CP036220:1178373-1178561 [Mycobacterium avium subsp. hominissuis]
ATGGGATTCCTGGACAAGGCCAAGGACCTGTTGTCGCAGAACGCCGACAAGGTCGAGATGGCCATCGACAAGGCCGGCGA
GTTCGTCGACGAAAAGACGCAGGGCAAGTACTCCGACACCATCCACCAGGTGCAGGAGCAGGCCAAGAAGGCCACCGGCG
CCACCGAGACCGGCGACCAGCAGGGCTGA

Structures

Antitoxin

• AlphaFold DB: A0A0E2WC18