Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-PHD
Location 966934..967601 Replicon chromosome
Accession NZ_CP036220
Organism Mycobacterium avium subsp. hominissuis strain mc2 2500

Toxin (Protein)


Gene name vapC Uniprot ID D5PE24
Locus tag EX350_RS04790 Protein ID WP_007168407.1
Coordinates 967209..967601 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID D5PE23
Locus tag EX350_RS04785 Protein ID WP_007168406.1
Coordinates 966934..967209 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EX350_RS04750 962438..962764 - 327 WP_033711234.1 hypothetical protein -
EX350_RS04755 962754..962987 - 234 Protein_933 transposase -
EX350_RS04760 963005..964216 - 1212 Protein_934 ISL3 family transposase -
EX350_RS04765 964355..964987 - 633 Protein_935 DDE-type integrase/transposase/recombinase -
EX350_RS04770 964939..965079 - 141 WP_145958858.1 SDR family oxidoreductase -
EX350_RS04775 965123..965826 - 704 Protein_937 histidine phosphatase family protein -
EX350_RS04780 965909..966781 + 873 WP_007168405.1 MaoC family dehydratase N-terminal domain-containing protein -
EX350_RS04785 966934..967209 + 276 WP_007168406.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EX350_RS04790 967209..967601 + 393 WP_007168407.1 type II toxin-antitoxin system VapC family toxin Toxin
EX350_RS04795 967749..968908 - 1160 Protein_941 trehalose-phosphatase -
EX350_RS04800 968950..970288 - 1339 Protein_942 DUF1298 domain-containing protein -
EX350_RS04805 970549..970671 - 123 Protein_943 IS1595 family transposase -
EX350_RS04810 971008..972342 + 1335 Protein_944 IS1182 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 933187..999918 66731


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-119)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-45)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14305.73 Da        Isoelectric Point: 10.5032

>T119374 WP_007168407.1 NZ_CP036220:967209-967601 [Mycobacterium avium subsp. hominissuis]
MAAIYLDSSAIVKLAVREPESDALRRYLRTRLPRVSSALARTEVMRALLHKGESARRAGRRALASLDLLRIDNRLLDLAG
GLLPIELRTLDAIHLATAQRLGMDLGRLCTYDDRMRDAAEALGMAVIAPS

Download         Length: 393 bp

>T119374 NZ_CP036220:967209-967601 [Mycobacterium avium subsp. hominissuis]
ATGGCGGCCATCTACCTGGACTCGTCCGCAATCGTCAAGCTTGCAGTTCGTGAGCCAGAGTCGGATGCGCTGCGTCGCTA
CCTTCGCACCCGGCTGCCGCGGGTGTCGAGTGCCCTTGCGCGGACGGAGGTCATGCGGGCTCTGCTCCACAAGGGTGAAT
CAGCCCGAAGAGCCGGACGCCGGGCGCTCGCGAGCCTAGACCTACTACGCATCGACAACCGATTGCTCGATCTTGCTGGT
GGGCTGCTGCCAATCGAGCTACGCACCCTCGATGCAATTCACCTGGCGACTGCCCAGCGGCTCGGCATGGATCTTGGCCG
GTTGTGCACTTACGACGACCGCATGCGCGACGCCGCCGAGGCGCTCGGCATGGCAGTGATTGCCCCGTCTTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10150.63 Da        Isoelectric Point: 5.1881

>AT119374 WP_007168406.1 NZ_CP036220:966934-967209 [Mycobacterium avium subsp. hominissuis]
MSTVGVRELRQRASELLRRVEAGETIEITDRGRPIALLSPMPEGGPYQQMLASGGIERATLDFDDLPEPVRLKTGIELPS
VTLARLREHER

Download         Length: 276 bp

>AT119374 NZ_CP036220:966934-967209 [Mycobacterium avium subsp. hominissuis]
ATGTCTACGGTGGGCGTTCGTGAGCTGCGGCAGCGGGCCAGCGAACTCCTCCGTCGGGTCGAGGCCGGCGAGACGATCGA
GATCACCGACCGTGGTCGGCCTATCGCCCTTCTCTCGCCGATGCCGGAGGGCGGTCCGTACCAGCAGATGCTGGCAAGCG
GCGGGATCGAACGTGCGACGCTTGACTTTGATGACCTTCCCGAGCCGGTCCGACTCAAAACGGGTATCGAGCTGCCGTCC
GTGACGCTTGCGCGCCTGCGTGAGCACGAGCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X1XV84

Antitoxin

Source ID Structure
AlphaFold DB A0A1X1XUZ3

References