119373

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Rv0298-Rv0299/-
Location 765601..766130 Replicon chromosome
Accession NZ_CP036220
Organism Mycobacterium avium subsp. hominissuis strain mc2 2500

Toxin (Protein)


Gene name Rv0299 Uniprot ID X7VD93
Locus tag EX350_RS03855 Protein ID WP_007172144.1
Coordinates 765601..765906 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name Rv0298 Uniprot ID D5P1N8
Locus tag EX350_RS03860 Protein ID WP_007172145.1
Coordinates 765903..766130 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EX350_RS03825 760679..760819 + 141 WP_007172137.1 hypothetical protein -
EX350_RS03830 760816..761202 + 387 WP_007172138.1 YbaB/EbfC family nucleoid-associated protein -
EX350_RS03835 761272..761949 + 678 WP_101930854.1 hypothetical protein -
EX350_RS03840 761949..762281 + 333 WP_033717256.1 hypothetical protein -
EX350_RS03845 762569..762856 + 288 WP_007172141.1 hypothetical protein -
EX350_RS03850 762875..765229 + 2355 WP_007172142.1 hypothetical protein -
EX350_RS03855 765601..765906 - 306 WP_007172144.1 hypothetical protein Toxin
EX350_RS03860 765903..766130 - 228 WP_007172145.1 ribbon-helix-helix protein, CopG family Antitoxin
EX350_RS03865 766616..768106 + 1491 WP_007172147.1 type VII secretion protein EccB -
EX350_RS03870 768180..769235 + 1056 WP_007172148.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 713915..783178 69263


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Ribbon-helix-helix protein, CopG

(6-41)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 10428.23 Da        Isoelectric Point: 3.9382

>T119373 WP_007172144.1 NZ_CP036220:c765906-765601 [Mycobacterium avium subsp. hominissuis]
VITPGDITPGRDTNQELYVVVLSNTIHLAAATGQVIICPFIPGEIPSSTMAMIVTVLQPKGVVLPELIQWLPVAALDQPI
GNIGGIALADTTTTAVTALIS

Download         Length: 306 bp

>T119373 NZ_CP036220:c765906-765601 [Mycobacterium avium subsp. hominissuis]
GTGATCACACCCGGAGACATCACGCCAGGCCGCGACACCAACCAGGAACTGTACGTTGTCGTACTATCTAACACGATTCA
CCTCGCAGCCGCCACCGGCCAGGTGATCATCTGCCCCTTCATTCCCGGTGAAATCCCCAGCAGCACAATGGCTATGATCG
TCACAGTGCTGCAACCCAAAGGGGTTGTCTTACCGGAGCTCATCCAGTGGCTTCCTGTCGCGGCCCTCGACCAACCCATC
GGCAATATCGGCGGCATCGCGCTCGCTGACACGACCACGACCGCCGTCACCGCGCTCATTTCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8153.21 Da        Isoelectric Point: 5.0079

>AT119373 WP_007172145.1 NZ_CP036220:c766130-765903 [Mycobacterium avium subsp. hominissuis]
MAKAKVSVMIEEAVLAAADADAQAAGLNRSEMIERALHNEHLRISLENYTTHTVPTLDIDAYAEKVYQANRAAGL

Download         Length: 228 bp

>AT119373 NZ_CP036220:c766130-765903 [Mycobacterium avium subsp. hominissuis]
ATGGCGAAAGCCAAAGTGTCCGTAATGATTGAAGAGGCCGTGCTGGCGGCGGCCGATGCGGACGCCCAGGCGGCCGGGCT
GAATCGTTCAGAGATGATCGAACGAGCCCTGCACAACGAGCATCTCCGAATCTCGCTCGAGAACTACACAACACACACTG
TGCCAACGCTCGACATCGACGCCTACGCGGAGAAGGTCTATCAGGCGAACCGGGCCGCTGGCCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X1XDZ0

Antitoxin

Source ID Structure
AlphaFold DB A0A1X1XDJ0

References