Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/ParE-RelB |
Location | 48033..48559 | Replicon | plasmid punnamed2 |
Accession | NZ_CP036204 | ||
Organism | Escherichia coli strain L725 |
Toxin (Protein)
Gene name | relE | Uniprot ID | S1EXL1 |
Locus tag | D9K49_RS24575 | Protein ID | WP_000323025.1 |
Coordinates | 48033..48320 (-) | Length | 96 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | S1F6D3 |
Locus tag | D9K49_RS24580 | Protein ID | WP_000534858.1 |
Coordinates | 48320..48559 (-) | Length | 80 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
D9K49_RS24540 | 43431..43586 | + | 156 | WP_000587091.1 | hypothetical protein | - |
D9K49_RS24545 | 43637..44749 | + | 1113 | WP_001300563.1 | IS4-like element IS421 family transposase | - |
D9K49_RS24550 | 44922..46304 | + | 1383 | Protein_51 | group II intron reverse transcriptase/maturase | - |
D9K49_RS24555 | 46385..46852 | + | 468 | Protein_52 | IS3 family transposase | - |
D9K49_RS24560 | 46883..47089 | - | 207 | Protein_53 | hypothetical protein | - |
D9K49_RS24565 | 47526..47750 | - | 225 | Protein_54 | hypothetical protein | - |
D9K49_RS24575 | 48033..48320 | - | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
D9K49_RS24580 | 48320..48559 | - | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
D9K49_RS25310 | 48901..49050 | + | 150 | WP_000550473.1 | hypothetical protein | - |
D9K49_RS24585 | 49107..49811 | - | 705 | WP_001067858.1 | IS6-like element IS26 family transposase | - |
D9K49_RS25440 | 49875..49997 | + | 123 | Protein_59 | IS66 family insertion sequence element accessory protein TnpB | - |
D9K49_RS24595 | 50089..50870 | - | 782 | Protein_60 | IS21-like element helper ATPase IstB | - |
D9K49_RS24600 | 50867..51475 | - | 609 | Protein_61 | transposase | - |
D9K49_RS24605 | 51489..51861 | - | 373 | Protein_62 | IS1 family transposase | - |
D9K49_RS24610 | 52188..52885 | - | 698 | Protein_63 | IS1 family transposase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Mobilizable plasmid | oqxA / blaCTX-M-55 | - | 1..65959 | 65959 | |
- | inside | IScluster/Tn | - | - | 39635..53633 | 13998 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T119371 WP_000323025.1 NZ_CP036204:c48320-48033 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T119371 NZ_CP036204:c48320-48033 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT119371 WP_000534858.1 NZ_CP036204:c48559-48320 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT119371 NZ_CP036204:c48559-48320 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGCGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGCGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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