119354

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2844674..2845299 Replicon chromosome
Accession NZ_CP036202
Organism Escherichia coli strain L725

Toxin (Protein)


Gene name vapC Uniprot ID A0A2J1DF47
Locus tag D9K49_RS13775 Protein ID WP_000911331.1
Coordinates 2844901..2845299 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag D9K49_RS13770 Protein ID WP_000450524.1
Coordinates 2844674..2844901 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D9K49_RS13745 2840477..2840947 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
D9K49_RS13750 2840947..2841519 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
D9K49_RS13755 2841665..2842543 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
D9K49_RS13760 2842560..2843594 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
D9K49_RS13765 2843807..2844520 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
D9K49_RS13770 2844674..2844901 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
D9K49_RS13775 2844901..2845299 + 399 WP_000911331.1 tRNA(fMet)-specific endonuclease VapC Toxin
D9K49_RS13780 2845446..2846309 + 864 WP_001267507.1 neutral zinc metallopeptidase -
D9K49_RS13785 2846324..2848339 + 2016 WP_001543081.1 tRNA cytosine(34) acetyltransferase TmcA -
D9K49_RS13790 2848413..2849111 + 699 WP_000679812.1 esterase -
D9K49_RS13795 2849221..2849421 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14862.19 Da        Isoelectric Point: 9.2216

>T119354 WP_000911331.1 NZ_CP036202:2844901-2845299 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLVELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

>T119354 NZ_CP036202:2844901-2845299 [Escherichia coli]
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGGTGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTTATTGAAGGTTTCGTATCTCGTTTGGTAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACC
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTAACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGACTGGAGCTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT119354 WP_000450524.1 NZ_CP036202:2844674-2844901 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp

>AT119354 NZ_CP036202:2844674-2844901 [Escherichia coli]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAAGACGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J1DF47

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References