Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 2802316..2802979 Replicon chromosome
Accession NZ_CP036202
Organism Escherichia coli strain L725

Toxin (Protein)


Gene name tad Uniprot ID -
Locus tag D9K49_RS13560 Protein ID WP_079815800.1
Coordinates 2802635..2802979 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID -
Locus tag D9K49_RS13555 Protein ID WP_130723412.1
Coordinates 2802316..2802633 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D9K49_RS13505 2797780..2798235 - 456 WP_130723403.1 phage virion morphogenesis protein -
D9K49_RS13510 2798235..2798693 - 459 WP_130723404.1 phage tail protein -
D9K49_RS13515 2798789..2799238 - 450 WP_130723405.1 Rz-like lysis system protein LysB -
D9K49_RS13520 2799235..2799825 - 591 WP_130723406.1 N-acetylmuramidase family protein -
D9K49_RS13525 2799803..2800117 - 315 WP_130723407.1 phage holin family protein -
D9K49_RS13530 2800114..2800491 - 378 WP_130723408.1 phage holin family protein -
D9K49_RS13535 2800494..2800697 - 204 WP_130723409.1 tail protein X -
D9K49_RS13540 2800812..2801132 - 321 WP_089558876.1 hypothetical protein -
D9K49_RS13545 2801122..2801328 - 207 WP_130723410.1 hypothetical protein -
D9K49_RS25235 2801461..2801637 + 177 WP_165394696.1 hypothetical protein -
D9K49_RS13550 2801689..2802222 + 534 WP_130723411.1 hypothetical protein -
D9K49_RS13555 2802316..2802633 - 318 WP_130723412.1 helix-turn-helix domain-containing protein Antitoxin
D9K49_RS13560 2802635..2802979 - 345 WP_079815800.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
D9K49_RS13565 2803075..2803281 - 207 WP_130723413.1 hypothetical protein -
D9K49_RS13570 2803281..2803517 - 237 WP_089558884.1 hypothetical protein -
D9K49_RS13575 2803633..2804100 - 468 WP_130723414.1 head completion/stabilization protein -
D9K49_RS13580 2804186..2804848 - 663 WP_130723415.1 terminase -
D9K49_RS13585 2804845..2805864 - 1020 WP_001243415.1 phage major capsid protein, P2 family -
D9K49_RS13590 2805875..2806702 - 828 WP_130723416.1 GPO family capsid scaffolding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2773114..2822553 49439


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(35-86)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12407.16 Da        Isoelectric Point: 9.6948

>T119353 WP_079815800.1 NZ_CP036202:c2802979-2802635 [Escherichia coli]
MKPLYWVGSSKKDLQSLPDDVQDVFGYALHLAQAGGKHSQTKPLKGFGGAGVLEVVEDFLGDTFRAVYTVKFGDAVYVLH
AFQKKSSSGIATPKPDMDKIRERLKAAENHARGA

Download         Length: 345 bp

>T119353 NZ_CP036202:c2802979-2802635 [Escherichia coli]
ATGAAGCCACTATATTGGGTTGGTAGTAGTAAGAAAGACCTCCAGTCATTGCCCGACGATGTACAGGATGTTTTCGGCTA
TGCCCTGCATCTGGCGCAGGCTGGCGGTAAACATTCCCAGACCAAACCACTGAAAGGGTTTGGTGGGGCCGGTGTTCTTG
AGGTGGTAGAAGACTTTCTCGGTGATACTTTTCGTGCGGTGTATACCGTTAAGTTCGGTGATGCCGTCTATGTTTTGCAC
GCATTCCAGAAAAAGTCTTCATCGGGGATCGCCACGCCGAAGCCTGATATGGACAAAATCCGCGAACGGCTGAAAGCCGC
AGAAAACCATGCCAGAGGAGCATAA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11569.51 Da        Isoelectric Point: 10.4692

>AT119353 WP_130723412.1 NZ_CP036202:c2802633-2802316 [Escherichia coli]
MSHDIEVSSGNVYADIGRDDAEEMLVKAQLATTIGNIIKSRRLTQEQAAKLLGMTQPKLSNMLRGQFRGISEAKMLECLT
RLGRDVQIVVGKPRRTPGSLKVIFA

Download         Length: 318 bp

>AT119353 NZ_CP036202:c2802633-2802316 [Escherichia coli]
ATGAGCCATGATATTGAAGTCAGCAGCGGCAACGTTTATGCCGATATTGGCAGAGACGACGCAGAAGAAATGCTGGTCAA
AGCCCAGCTTGCCACCACTATTGGCAACATCATCAAAAGCCGTCGTCTGACGCAGGAACAAGCAGCAAAACTACTGGGAA
TGACACAACCCAAATTGTCCAATATGCTGCGTGGGCAGTTCCGGGGTATCAGCGAAGCCAAAATGCTGGAATGTCTGACT
CGCTTAGGGCGTGATGTGCAAATCGTGGTAGGAAAGCCGCGTCGGACACCGGGCAGTCTGAAGGTAATTTTTGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References