Detailed information of TA system TA119353

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tad-ata/COG5606-COG4679
• Location: 2802316..2802979
• Replicon: chromosome
• Accession: NZ_CP036202
• Organism: Escherichia coli strain L725

Toxin (Protein)

• Gene name: tad
• Uniprot ID: -
• Locus tag: D9K49_RS13560
• Protein ID: WP_079815800.1
• Coordinates: 2802635..2802979 (-)
• Length: 115 a.a.

Antitoxin (Protein)

• Gene name: ata
• Uniprot ID: -
• Locus tag: D9K49_RS13555
• Protein ID: WP_130723412.1
• Coordinates: 2802316..2802633 (-)
• Length: 106 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2773114..2822553	49439

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-105)

Antitoxin

• Cro/C1-type helix-turn-helix domain (35-86)

Sequences

Toxin

Protein

• Length: 115 a.a.
• Molecular weight: 12407.16 Da
• Isoelectric Point: 9.6948

>T119353 WP_079815800.1 NZ_CP036202:c2802979-2802635 [Escherichia coli]
MKPLYWVGSSKKDLQSLPDDVQDVFGYALHLAQAGGKHSQTKPLKGFGGAGVLEVVEDFLGDTFRAVYTVKFGDAVYVLH
AFQKKSSSGIATPKPDMDKIRERLKAAENHARGA

Nucleotide

• Length: 345 bp

>T119353 NZ_CP036202:c2802979-2802635 [Escherichia coli]
ATGAAGCCACTATATTGGGTTGGTAGTAGTAAGAAAGACCTCCAGTCATTGCCCGACGATGTACAGGATGTTTTCGGCTA
TGCCCTGCATCTGGCGCAGGCTGGCGGTAAACATTCCCAGACCAAACCACTGAAAGGGTTTGGTGGGGCCGGTGTTCTTG
AGGTGGTAGAAGACTTTCTCGGTGATACTTTTCGTGCGGTGTATACCGTTAAGTTCGGTGATGCCGTCTATGTTTTGCAC
GCATTCCAGAAAAAGTCTTCATCGGGGATCGCCACGCCGAAGCCTGATATGGACAAAATCCGCGAACGGCTGAAAGCCGC
AGAAAACCATGCCAGAGGAGCATAA

Antitoxin

Protein

• Length: 106 a.a.
• Molecular weight: 11569.51 Da
• Isoelectric Point: 10.4692

>AT119353 WP_130723412.1 NZ_CP036202:c2802633-2802316 [Escherichia coli]
MSHDIEVSSGNVYADIGRDDAEEMLVKAQLATTIGNIIKSRRLTQEQAAKLLGMTQPKLSNMLRGQFRGISEAKMLECLT
RLGRDVQIVVGKPRRTPGSLKVIFA

Nucleotide

• Length: 318 bp

>AT119353 NZ_CP036202:c2802633-2802316 [Escherichia coli]
ATGAGCCATGATATTGAAGTCAGCAGCGGCAACGTTTATGCCGATATTGGCAGAGACGACGCAGAAGAAATGCTGGTCAA
AGCCCAGCTTGCCACCACTATTGGCAACATCATCAAAAGCCGTCGTCTGACGCAGGAACAAGCAGCAAAACTACTGGGAA
TGACACAACCCAAATTGTCCAATATGCTGCGTGGGCAGTTCCGGGGTATCAGCGAAGCCAAAATGCTGGAATGTCTGACT
CGCTTAGGGCGTGATGTGCAAATCGTGGTAGGAAAGCCGCGTCGGACACCGGGCAGTCTGAAGGTAATTTTTGCCTGA