Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4385322..4385941 Replicon chromosome
Accession NZ_CP036199
Organism Leclercia adecarboxylata strain 16005813

Toxin (Protein)


Gene name Hha Uniprot ID A0A345CDT0
Locus tag EXN74_RS21195 Protein ID WP_032616864.1
Coordinates 4385723..4385941 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A3E1ZZ82
Locus tag EXN74_RS21190 Protein ID WP_032616865.1
Coordinates 4385322..4385714 (+) Length 131 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EXN74_RS21180 4380475..4381668 + 1194 WP_032616867.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
EXN74_RS21185 4381691..4384831 + 3141 WP_059308599.1 multidrug efflux RND transporter permease subunit AcrB -
EXN74_RS21190 4385322..4385714 + 393 WP_032616865.1 Hha toxicity modulator TomB Antitoxin
EXN74_RS21195 4385723..4385941 + 219 WP_032616864.1 hemolysin expression modulator Hha Toxin
EXN74_RS21200 4386213..4386677 + 465 WP_032616863.1 membrane protein -
EXN74_RS21205 4386737..4386877 - 141 WP_032616862.1 type B 50S ribosomal protein L36 -
EXN74_RS21210 4387143..4388711 + 1569 WP_130589227.1 EAL domain-containing protein -
EXN74_RS21215 4388744..4389097 - 354 WP_059308601.1 DUF1428 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T119343 WP_032616864.1 NZ_CP036199:4385723-4385941 [Leclercia adecarboxylata]
MSDKPLTKTDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTAVWKFVR

Download         Length: 219 bp

>T119343 NZ_CP036199:4385723-4385941 [Leclercia adecarboxylata]
ATGTCTGATAAACCCTTAACCAAGACAGATTATTTGATGCGTTTGCGACGCTGTCAGTCAATTGACACCCTTGAACGTGT
GATTGAGAAAAATAAATACGAGCTTTCTGATAATGAGTTAGCAGTATTCTATTCTGCAGCCGATCATCGTCTGGCTGAAC
TCACTATGAATAAGCTGTATGATAAAATCCCGACAGCCGTGTGGAAGTTTGTACGCTGA

Antitoxin


Download         Length: 131 a.a.        Molecular weight: 15093.98 Da        Isoelectric Point: 4.8941

>AT119343 WP_032616865.1 NZ_CP036199:4385322-4385714 [Leclercia adecarboxylata]
MDEYSPKRQDIAQLKFLCESLYHDCLSNLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNASKANPLASPVKIITNN

Download         Length: 393 bp

>AT119343 NZ_CP036199:4385322-4385714 [Leclercia adecarboxylata]
ATGGACGAATACTCGCCTAAAAGGCAAGATATTGCACAGTTGAAATTCCTTTGTGAATCCCTGTACCATGACTGCCTTTC
CAATCTCGATGAAAGCAACCATGGCTGGGTCAATGACCCTACTTCTGCCATTAATTTGCAGTTAAACGAGTTGATTGAGC
ATATAGCAACCTTCGCGCTTAATTATAAAATTAAGTATAACGAAGATAATAAGTTGATTGAGCAAATTGACGAATACCTG
GATGACACTTTTATGTTATTCAGCAGCTACGGCATTAATGCACAGGATTTGCAAAAATGGCGTAAATCGGGCAATCGGCT
TTTTCGGTGTTTTGTCAATGCAAGCAAGGCTAACCCGTTAGCTTCGCCAGTTAAAATTATTACAAACAATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A345CDT0

Antitoxin

Source ID Structure
AlphaFold DB A0A3E1ZZ82

References