Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 3260630..3262195 Replicon chromosome
Accession NZ_CP036199
Organism Leclercia adecarboxylata strain 16005813

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag EXN74_RS15800 Protein ID WP_130588857.1
Coordinates 3260885..3262195 (+) Length 437 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag EXN74_RS15795 Protein ID WP_032618098.1
Coordinates 3260630..3260881 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EXN74_RS15790 3256030..3259830 - 3801 WP_130588856.1 glycosyltransferase -
EXN74_RS15795 3260630..3260881 + 252 WP_032618098.1 helix-turn-helix domain-containing protein Antitoxin
EXN74_RS15800 3260885..3262195 + 1311 WP_130588857.1 type II toxin-antitoxin system HipA family toxin Toxin
EXN74_RS15805 3262330..3263391 + 1062 WP_130588858.1 YncE family protein -
EXN74_RS15810 3263402..3265399 + 1998 WP_103792383.1 TonB-dependent receptor -
EXN74_RS15815 3265532..3266713 + 1182 WP_130588859.1 PLP-dependent aminotransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(6-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(10-64)


Sequences

Toxin        


Download         Length: 437 a.a.        Molecular weight: 48196.35 Da        Isoelectric Point: 6.5047

>T119341 WP_130588857.1 NZ_CP036199:3260885-3262195 [Leclercia adecarboxylata]
MRAQRLTVAMNGDVVGTLHRDGSGAMSFQYAPEWLAEPGSRAISLSLPLQHGRIRGAQVFNFFSNLLPDSEAIIARMQAR
FQVETAHPFDLLASVGRDCVGAIQLYPPGQEIPPVTDIVAEPLDDDQIAALLDGYQMAPLGMTEEDADFRISLAGAQEKT
ALLWYQARWQRPQGSTPTSHIFKLPIGRIEQNNIDLSESCENEWLCLRIAKAFGFPVAQAEMATFGRKKVLIIERFDRRW
SSSGWLMRLPQEDFCQALGVSPALKYESHGGPGIADAMKLLLGSRLAGQDRELFFKAQILFWMLAAIDGHGKNFSLFIEA
DSAFRMAPLYDVISAFPLFEAGGIPVKKAKMAMALQGKNRQYHFAMIQPRHFISTAAFAGYSQEAARRLLAEMAERTDDV
IASVRAELPPDFPAQVSEAIFKGLASQAARIGRFVS

Download         Length: 1311 bp

>T119341 NZ_CP036199:3260885-3262195 [Leclercia adecarboxylata]
ATGCGCGCACAACGACTGACTGTCGCGATGAATGGCGACGTAGTGGGGACGCTGCATCGTGACGGCAGCGGGGCAATGTC
CTTCCAGTATGCCCCGGAATGGCTGGCCGAGCCGGGTTCGCGCGCGATTTCGCTCTCTTTGCCGCTACAGCACGGCAGGA
TCAGAGGCGCGCAGGTCTTTAATTTCTTCAGTAATCTGCTGCCTGACTCTGAGGCGATTATTGCCCGCATGCAGGCCCGA
TTCCAGGTTGAAACCGCTCATCCCTTTGATCTGCTGGCCAGTGTCGGGCGTGACTGTGTGGGCGCCATTCAGCTCTATCC
GCCGGGACAGGAGATCCCCCCGGTAACGGATATTGTGGCCGAACCGCTGGATGATGATCAGATTGCCGCGCTGCTCGACG
GGTATCAGATGGCACCCCTGGGGATGACCGAGGAGGATGCTGACTTTCGCATTTCGCTGGCTGGCGCGCAGGAGAAAACG
GCGCTGCTGTGGTACCAGGCGCGCTGGCAGCGGCCCCAGGGTAGCACCCCAACCAGTCATATCTTTAAGCTGCCGATCGG
CAGAATAGAACAAAACAATATCGACCTGAGCGAAAGTTGTGAAAACGAATGGCTGTGTTTGCGCATTGCCAAAGCCTTTG
GTTTCCCAGTGGCACAGGCGGAGATGGCAACCTTTGGCCGCAAGAAAGTGCTGATTATCGAGCGTTTCGACCGTCGTTGG
TCCAGCAGCGGGTGGCTGATGCGTCTGCCGCAGGAAGATTTTTGCCAGGCCCTGGGCGTGTCGCCAGCGCTGAAATATGA
ATCTCACGGTGGTCCCGGGATTGCCGACGCCATGAAGCTGCTGCTCGGTTCCCGCCTGGCGGGGCAGGATCGCGAGCTGT
TCTTTAAGGCGCAGATCCTGTTCTGGATGCTGGCCGCCATTGATGGTCACGGGAAGAATTTCAGCCTGTTTATCGAGGCG
GATTCCGCCTTTCGCATGGCCCCGCTGTACGACGTGATTTCCGCGTTTCCGCTGTTCGAAGCAGGGGGGATCCCGGTCAA
AAAAGCGAAGATGGCGATGGCGTTACAGGGCAAGAACCGGCAGTACCATTTTGCGATGATCCAACCGCGTCACTTCATCA
GCACCGCTGCTTTTGCAGGTTATTCCCAGGAGGCCGCTCGCCGTTTGCTGGCCGAGATGGCGGAGCGAACAGACGACGTG
ATTGCCTCCGTCAGGGCAGAATTGCCACCGGATTTCCCCGCGCAGGTCAGTGAGGCCATTTTTAAGGGTTTAGCCAGCCA
GGCGGCAAGAATAGGGCGGTTCGTGAGTTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9223.56 Da        Isoelectric Point: 10.1945

>AT119341 WP_032618098.1 NZ_CP036199:3260630-3260881 [Leclercia adecarboxylata]
MKVTSADALAQAVRDQRKVNKLTQTATAEQVGIKQTTVSEFENKPGSTKLETLFKILSALDLELHVVKRGGTLPDNNAWK
KEW

Download         Length: 252 bp

>AT119341 NZ_CP036199:3260630-3260881 [Leclercia adecarboxylata]
ATGAAAGTTACATCGGCAGACGCACTGGCTCAGGCTGTCCGGGATCAGCGTAAGGTCAATAAGTTAACCCAAACGGCAAC
GGCTGAACAGGTGGGGATTAAACAAACCACGGTATCGGAATTTGAGAACAAACCAGGCTCTACCAAACTGGAAACCTTGT
TCAAAATCCTCTCGGCGCTGGATCTGGAGCTGCACGTGGTGAAACGAGGCGGCACGCTGCCGGATAACAATGCCTGGAAG
AAGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References