Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 3191500..3192074 Replicon chromosome
Accession NZ_CP036199
Organism Leclercia adecarboxylata strain 16005813

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag EXN74_RS15505 Protein ID WP_130588828.1
Coordinates 3191500..3191826 (-) Length 109 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag EXN74_RS15510 Protein ID WP_130588829.1
Coordinates 3191826..3192074 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EXN74_RS15480 3187024..3187992 + 969 WP_117386488.1 ABC transporter substrate-binding protein -
EXN74_RS15485 3188031..3189686 + 1656 WP_130588826.1 iron ABC transporter permease -
EXN74_RS15490 3189883..3190728 + 846 WP_059307893.1 N-hydroxyarylamine O-acetyltransferase -
EXN74_RS15500 3190962..3191411 + 450 WP_130588827.1 hypothetical protein -
EXN74_RS15505 3191500..3191826 - 327 WP_130588828.1 endoribonuclease MazF Toxin
EXN74_RS15510 3191826..3192074 - 249 WP_130588829.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
EXN74_RS15515 3192255..3192935 - 681 WP_032618185.1 respiratory nitrate reductase subunit gamma -
EXN74_RS15520 3192932..3193627 - 696 WP_130588830.1 nitrate reductase molybdenum cofactor assembly chaperone -
EXN74_RS15525 3193627..3195171 - 1545 WP_032618187.1 nitrate reductase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-107)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 11875.64 Da        Isoelectric Point: 7.8831

>T119340 WP_130588828.1 NZ_CP036199:c3191826-3191500 [Leclercia adecarboxylata]
MDYIPEAGDIVWLDFDPQSGHEQAGHRPALVVSPATYNGRTGLMLCCPLTSQIKNYPFEVVISGARRNVALADQIKSLDW
RARHAVKKGTATAEELDAVRMRAKVLIG

Download         Length: 327 bp

>T119340 NZ_CP036199:c3191826-3191500 [Leclercia adecarboxylata]
ATGGACTACATCCCGGAAGCGGGCGATATCGTCTGGCTGGATTTTGATCCGCAGTCAGGTCATGAACAGGCAGGCCATCG
CCCTGCGCTGGTTGTTTCACCCGCCACTTACAATGGACGCACCGGTCTGATGCTCTGCTGTCCACTTACGTCGCAAATCA
AAAACTACCCCTTCGAAGTTGTCATTAGCGGAGCACGCCGCAATGTCGCCCTCGCCGATCAGATCAAAAGTCTGGACTGG
CGCGCGCGTCACGCAGTGAAAAAGGGAACGGCAACTGCCGAAGAACTGGATGCCGTGAGAATGCGGGCGAAGGTTTTGAT
CGGCTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9114.36 Da        Isoelectric Point: 4.3431

>AT119340 WP_130588829.1 NZ_CP036199:c3192074-3191826 [Leclercia adecarboxylata]
MPQVTVKKWGNSPSVRLPVAVMREAELHVDDVVNVNVDEEGRIILTPVRKDEPTLESLLAAITDDNLHNEVTFGEPQGKE
LL

Download         Length: 249 bp

>AT119340 NZ_CP036199:c3192074-3191826 [Leclercia adecarboxylata]
ATGCCGCAAGTCACCGTCAAAAAATGGGGTAACAGCCCTTCTGTCAGGCTGCCTGTCGCAGTTATGCGCGAGGCTGAATT
GCACGTTGACGATGTGGTGAACGTTAACGTAGACGAAGAAGGACGCATTATTTTGACTCCCGTCAGGAAGGACGAACCGA
CGCTGGAATCGCTGCTCGCTGCGATCACCGACGACAATCTGCACAACGAAGTCACCTTTGGAGAACCGCAAGGTAAGGAG
CTGTTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References