Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4330032..4330689 Replicon chromosome
Accession NZ_CP036190
Organism Klebsiella pneumoniae strain BA34918

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag EX353_RS21500 Protein ID WP_002916310.1
Coordinates 4330279..4330689 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag EX353_RS21495 Protein ID WP_002916312.1
Coordinates 4330032..4330298 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EX353_RS21470 4325240..4326673 - 1434 WP_130627928.1 6-phospho-beta-glucosidase BglA -
EX353_RS21475 4326792..4327520 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
EX353_RS21480 4327570..4327881 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
EX353_RS21485 4328045..4328704 + 660 WP_002916317.1 hemolysin III family protein -
EX353_RS21490 4328803..4329786 - 984 WP_014906951.1 tRNA-modifying protein YgfZ -
EX353_RS21495 4330032..4330298 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
EX353_RS21500 4330279..4330689 + 411 WP_002916310.1 protein YgfX Toxin
EX353_RS21505 4330696..4331217 - 522 WP_002916308.1 flavodoxin FldB -
EX353_RS21510 4331318..4332214 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
EX353_RS21515 4332237..4332950 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
EX353_RS21520 4332956..4334689 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T119325 WP_002916310.1 NZ_CP036190:4330279-4330689 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T119325 NZ_CP036190:4330279-4330689 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT119325 WP_002916312.1 NZ_CP036190:4330032-4330298 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT119325 NZ_CP036190:4330032-4330298 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References