Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3504991..3505609 Replicon chromosome
Accession NZ_CP036177
Organism Escherichia coli strain WCHEC025970

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag EYD11_RS17110 Protein ID WP_001291435.1
Coordinates 3505391..3505609 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag EYD11_RS17105 Protein ID WP_000344800.1
Coordinates 3504991..3505365 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EYD11_RS17095 3500080..3501273 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
EYD11_RS17100 3501296..3504445 + 3150 WP_001132469.1 multidrug efflux RND transporter permease subunit -
EYD11_RS17105 3504991..3505365 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
EYD11_RS17110 3505391..3505609 + 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
EYD11_RS17115 3505781..3506332 + 552 WP_000102564.1 maltose O-acetyltransferase -
EYD11_RS17120 3506448..3506918 + 471 WP_000136192.1 YlaC family protein -
EYD11_RS17125 3507082..3508632 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
EYD11_RS17130 3508674..3509027 - 354 WP_000878140.1 DUF1428 domain-containing protein -
EYD11_RS17140 3509406..3509717 + 312 WP_000409911.1 MGMT family protein -
EYD11_RS17145 3509748..3510320 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T119272 WP_001291435.1 NZ_CP036177:3505391-3505609 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T119272 NZ_CP036177:3505391-3505609 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT119272 WP_000344800.1 NZ_CP036177:3504991-3505365 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT119272 NZ_CP036177:3504991-3505365 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References