Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1859826..1860661 Replicon chromosome
Accession NZ_CP036177
Organism Escherichia coli strain WCHEC025970

Toxin (Protein)


Gene name yeeV Uniprot ID A0A1X9TM58
Locus tag EYD11_RS08865 Protein ID WP_000854761.1
Coordinates 1859826..1860203 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NM52
Locus tag EYD11_RS08870 Protein ID WP_001295723.1
Coordinates 1860293..1860661 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EYD11_RS08825 1855215..1855397 - 183 WP_001016348.1 hypothetical protein -
EYD11_RS08835 1855851..1856240 - 390 WP_001445118.1 IS110 family transposase -
EYD11_RS08840 1856734..1857138 + 405 WP_000839179.1 IS66 family insertion sequence hypothetical protein -
EYD11_RS08845 1857135..1857482 + 348 WP_000612626.1 IS66 family insertion sequence element accessory protein TnpB -
EYD11_RS08850 1857531..1859066 + 1536 WP_001333339.1 IS66-like element ISEc22 family transposase -
EYD11_RS08855 1859501..1859614 - 114 WP_001161660.1 DUF957 domain-containing protein -
EYD11_RS08860 1859627..1859829 - 203 Protein_1723 hypothetical protein -
EYD11_RS08865 1859826..1860203 - 378 WP_000854761.1 TA system toxin CbtA family protein Toxin
EYD11_RS08870 1860293..1860661 - 369 WP_001295723.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
EYD11_RS08875 1860824..1861045 - 222 WP_000692341.1 DUF987 domain-containing protein -
EYD11_RS08880 1861108..1861584 - 477 WP_001186774.1 RadC family protein -
EYD11_RS08885 1861600..1862073 - 474 WP_000855059.1 antirestriction protein -
EYD11_RS08895 1862415..1863233 - 819 WP_001234729.1 DUF945 domain-containing protein -
EYD11_RS08905 1863388..1863546 - 159 WP_001323397.1 DUF905 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1851568..1891209 39641


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14205.25 Da        Isoelectric Point: 7.3249

>T119261 WP_000854761.1 NZ_CP036177:c1860203-1859826 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

>T119261 NZ_CP036177:c1860203-1859826 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCATTACAGCCTTACGCTGAATGACACACCGTTCGTGGATGAACGCGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGAACTGACCAGCCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13592.40 Da        Isoelectric Point: 6.6255

>AT119261 WP_001295723.1 NZ_CP036177:c1860661-1860293 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT119261 NZ_CP036177:c1860661-1860293 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X9TM58

Antitoxin

Source ID Structure
AlphaFold DB S1NM52

References