Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 6088640..6089256 Replicon chromosome
Accession NZ_CP036175
Organism Klebsiella huaxiensis strain WCHKl090001

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag DA718_RS29115 Protein ID WP_112216889.1
Coordinates 6088640..6089014 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag DA718_RS29120 Protein ID WP_167492840.1
Coordinates 6089011..6089256 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DA718_RS29095 6083983..6085326 + 1344 WP_112216885.1 VWA domain-containing protein -
DA718_RS29100 6085344..6086837 + 1494 WP_112216886.1 HAMP domain-containing histidine kinase -
DA718_RS29105 6086841..6087527 + 687 WP_112216887.1 response regulator transcription factor -
DA718_RS29110 6087674..6088603 + 930 WP_112216888.1 formate dehydrogenase accessory protein FdhE -
DA718_RS29115 6088640..6089014 - 375 WP_112216889.1 type II toxin-antitoxin system VapC family toxin Toxin
DA718_RS29120 6089011..6089256 - 246 WP_167492840.1 ribbon-helix-helix domain-containing protein Antitoxin
DA718_RS29125 6089461..6090378 + 918 WP_112216891.1 alpha/beta hydrolase -
DA718_RS29130 6090396..6091337 - 942 WP_167492841.1 fatty acid biosynthesis protein FabY -
DA718_RS29135 6091382..6091819 - 438 WP_112216893.1 D-tyrosyl-tRNA(Tyr) deacylase -
DA718_RS29140 6091816..6092676 - 861 WP_112216894.1 virulence factor BrkB family protein -
DA718_RS29145 6092670..6093269 - 600 WP_112216895.1 glucose-1-phosphatase -
DA718_RS29150 6093383..6094168 - 786 WP_112216896.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-116)

Antitoxin

Ribbon-helix-helix protein, CopG

(13-47)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13945.12 Da        Isoelectric Point: 8.4717

>T119252 WP_112216889.1 NZ_CP036175:c6089014-6088640 [Klebsiella huaxiensis]
MSKGPALFDTNILIDLFSGRVEAKQALEAYSPQNAISLISWMEVMVGAKKYHQEHRTRIALSAFNIIGVSQDIAERSVNI
RQEYGMALPDAIILATAQMHRYELVTRNTKDFARIPGVITPYHL

Download         Length: 375 bp

>T119252 NZ_CP036175:c6089014-6088640 [Klebsiella huaxiensis]
ATGAGTAAAGGCCCGGCGCTGTTTGATACCAATATTCTCATTGATCTGTTCAGCGGACGCGTTGAAGCGAAACAGGCACT
GGAGGCTTATTCACCACAAAATGCGATTAGCCTTATCTCCTGGATGGAAGTGATGGTGGGAGCCAAAAAGTATCACCAGG
AACATCGTACGCGCATTGCACTGAGCGCTTTTAATATCATTGGTGTCTCACAGGATATTGCAGAACGAAGTGTCAACATC
AGGCAGGAGTATGGGATGGCGTTGCCGGATGCCATTATCCTGGCGACGGCACAAATGCATCGTTATGAACTCGTCACGCG
CAACACTAAAGATTTTGCCAGGATTCCAGGCGTGATTACGCCTTATCATTTGTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9487.66 Da        Isoelectric Point: 4.2805

>AT119252 WP_167492840.1 NZ_CP036175:c6089256-6089011 [Klebsiella huaxiensis]
MMAGRDVGRILLDLSDDVIKRLEDLKQQRNLPRAELLREAVEQYLERQGQAETTIADALGLWQGCEEDGVEYERKLREEW
Q

Download         Length: 246 bp

>AT119252 NZ_CP036175:c6089256-6089011 [Klebsiella huaxiensis]
ATGATGGCAGGAAGGGATGTGGGCAGAATATTACTCGACTTATCAGATGACGTTATCAAACGTCTTGAAGACCTCAAGCA
GCAGCGCAATCTTCCGCGAGCAGAACTGTTACGTGAAGCGGTAGAACAGTACCTGGAAAGGCAAGGCCAGGCTGAAACTA
CTATCGCCGATGCGCTGGGGCTTTGGCAAGGCTGCGAGGAAGATGGTGTTGAATATGAAAGGAAGCTTCGTGAGGAGTGG
CAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References