Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 5331709..5332513 Replicon chromosome
Accession NZ_CP036175
Organism Klebsiella huaxiensis strain WCHKl090001

Toxin (Protein)


Gene name yeeV Uniprot ID A0A486SQP3
Locus tag DA718_RS25435 Protein ID WP_040217122.1
Coordinates 5331709..5332098 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A7H4M120
Locus tag DA718_RS25440 Protein ID WP_014837280.1
Coordinates 5332154..5332513 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DA718_RS25405 5326884..5327396 + 513 WP_112216423.1 type 1 fimbrial protein -
DA718_RS25410 5327411..5327935 + 525 WP_112216422.1 type 1 fimbrial protein -
DA718_RS25415 5328156..5328824 + 669 WP_112216377.1 response regulator transcription factor -
DA718_RS25420 5329265..5329621 + 357 WP_130624405.1 hypothetical protein -
DA718_RS25425 5329838..5330635 - 798 WP_014837283.1 helix-turn-helix transcriptional regulator -
DA718_RS25430 5330777..5331622 - 846 WP_014837282.1 DUF4942 domain-containing protein -
DA718_RS25435 5331709..5332098 - 390 WP_040217122.1 TA system toxin CbtA family protein Toxin
DA718_RS25440 5332154..5332513 - 360 WP_014837280.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
DA718_RS25445 5332538..5332759 - 222 WP_014837279.1 DUF987 domain-containing protein -
DA718_RS25450 5332773..5333252 - 480 WP_014837278.1 DNA repair protein RadC -
DA718_RS25455 5333264..5333707 - 444 WP_014837277.1 antirestriction protein -
DA718_RS25460 5333787..5334035 - 249 WP_044347584.1 DUF905 domain-containing protein -
DA718_RS25465 5334041..5334865 - 825 WP_040217125.1 DUF945 domain-containing protein -
DA718_RS25470 5335403..5336035 + 633 WP_072040125.1 inovirus Gp2 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 5326872..5339635 12763


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(3-111)

Antitoxin

Antitoxin CbeA

(16-114)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14477.57 Da        Isoelectric Point: 8.9843

>T119250 WP_040217122.1 NZ_CP036175:c5332098-5331709 [Klebsiella huaxiensis]
MQTKSPPFMRAASSRPSPVGVWQTLLTCLLEHHYGLTLNDTPFSDELVIQQHIEAGISLADALNFIVEKYELVRTDRPGF
SIREQSPFITSIDILRARKATGLMNRDTYKEVTAITRGQHPQVSAPGKR

Download         Length: 390 bp

>T119250 NZ_CP036175:c5332098-5331709 [Klebsiella huaxiensis]
ATGCAAACCAAATCACCCCCCTTCATGCGGGCGGCATCGTCACGTCCGTCTCCCGTGGGCGTCTGGCAGACCCTGCTGAC
CTGCCTGCTGGAACACCACTATGGCCTTACGCTTAACGATACGCCGTTCAGTGATGAACTGGTGATTCAGCAACATATCG
AGGCGGGTATCTCGCTGGCCGATGCCCTGAATTTTATTGTTGAAAAGTATGAACTGGTCCGCACTGACCGGCCAGGCTTC
AGCATCAGGGAGCAGTCTCCGTTTATTACATCCATTGATATCCTCCGGGCCAGAAAGGCAACGGGGCTGATGAACCGTGA
CACGTATAAAGAGGTGACGGCTATTACCAGAGGGCAACATCCGCAGGTCAGTGCTCCAGGCAAGCGATGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13416.24 Da        Isoelectric Point: 7.0268

>AT119250 WP_014837280.1 NZ_CP036175:c5332513-5332154 [Klebsiella huaxiensis]
MSKKTTIATHDISESWWGLRRSVSACFGARLVQEGNRLHYLADRANFNGQFCDADLRHLDQSFPVLMKQLELMLTSGELN
PRHQHCVTLYAKGLTCEADTLGSHGYVYIAIYPTPVTTE

Download         Length: 360 bp

>AT119250 NZ_CP036175:c5332513-5332154 [Klebsiella huaxiensis]
TTGTCGAAGAAAACCACGATAGCAACGCATGATATCAGCGAATCCTGGTGGGGGCTCAGACGCAGTGTCTCCGCGTGTTT
TGGTGCCCGACTGGTCCAGGAGGGAAACCGCCTGCATTACCTGGCTGACCGCGCGAATTTTAACGGACAGTTCTGCGATG
CGGATTTGCGCCATCTTGACCAGTCTTTCCCGGTATTGATGAAACAGCTGGAGTTAATGCTCACCAGCGGTGAACTGAAT
CCCCGTCATCAGCACTGCGTCACGCTGTATGCAAAAGGTCTGACCTGCGAGGCCGATACGCTCGGTTCGCATGGCTACGT
TTATATCGCGATTTATCCCACTCCCGTCACCACAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486SQP3

Antitoxin

Source ID Structure
AlphaFold DB A0A7H4M120

References