Detailed information of TA system TA119249

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX(toxin)
• Location: 4781477..4782296
• Replicon: chromosome
• Accession: NZ_CP036175
• Organism: Klebsiella huaxiensis strain WCHKl090001

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: -
• Locus tag: DA718_RS22880
• Protein ID: WP_110273875.1
• Coordinates: 4782039..4782296 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: DA718_RS22875
• Protein ID: WP_112214026.1
• Coordinates: 4781477..4782028 (-)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DA718_RS22860	4777326..4778603	+	1278	WP_112214028.1	hypothetical protein	-
DA718_RS22865	4778620..4779783	+	1164	WP_110273872.1	MFS transporter	-
DA718_RS22870	4779831..4781465	-	1635	WP_112214027.1	SAM-dependent methyltransferase	-
DA718_RS22875	4781477..4782028	-	552	WP_112214026.1	N-acetyltransferase	Antitoxin
DA718_RS22880	4782039..4782296	-	258	WP_110273875.1	YjhX family toxin	Toxin
DA718_RS22890	4782615..4783589	-	975	WP_112214025.1	LacI family transcriptional regulator	-
DA718_RS22895	4783690..4784622	-	933	WP_112214024.1	ROK family protein	-
DA718_RS22900	4785150..4786334	+	1185	WP_112214023.1	mannonate dehydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (37-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9582.10 Da
• Isoelectric Point: 11.1381

>T119249 WP_110273875.1 NZ_CP036175:c4782296-4782039 [Klebsiella huaxiensis]
MNLSRQEQRTLHVLAKGGRIAHVRDTSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T119249 NZ_CP036175:c4782296-4782039 [Klebsiella huaxiensis]
ATGAATCTATCCCGTCAGGAACAACGTACCTTACACGTTCTCGCTAAAGGTGGTCGGATCGCGCACGTTCGCGATACTTC
AGGCCGCGTGACCTCTGTTGAATGCTACAGCCGCGAAGGGCTTCTGCTCACCGACTGTACTCTCGCCGTTTTCAAAAAAC
TCAAAACCAAAAAGCTGATTAAGTCCGTCAATGGGCAGCCCTACCGCATCAATACCACCGGACTGAACAACGTTCGCGCC
CAGTTGGATAATCGCTAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20173.14 Da
• Isoelectric Point: 6.3267

>AT119249 WP_112214026.1 NZ_CP036175:c4782028-4781477 [Klebsiella huaxiensis]
MTNHNFTFHITTEGDAGDICEVETRAFGFSKEAELVVDLLNDESACPRLSLLARHNGKAVGHILFTRATFKGESDSPMMH
ILAPLAVIPEYQGMGVGGWLIQSGIEHLKAMGSLAVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMLQLLSA
EPLGRTGQIQCARALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT119249 NZ_CP036175:c4782028-4781477 [Klebsiella huaxiensis]
ATGACAAACCACAACTTCACTTTTCATATCACTACCGAAGGTGACGCCGGTGATATTTGCGAGGTCGAAACCCGAGCGTT
CGGCTTTAGCAAAGAGGCTGAGCTGGTGGTCGATTTGCTCAACGATGAAAGCGCTTGCCCGAGGTTATCTCTGCTGGCCA
GACATAATGGAAAAGCGGTTGGGCATATTTTGTTCACCCGGGCGACATTTAAAGGAGAGTCTGACTCTCCGATGATGCAT
ATCCTTGCTCCTCTGGCGGTAATACCAGAATACCAGGGCATGGGGGTTGGCGGATGGCTAATCCAAAGCGGTATTGAGCA
TCTGAAGGCGATGGGGAGCCTGGCGGTATTTGTTCTGGGACATGCCACTTATTACCCGCGGCATGGCTTTGAACCTTGCG
CCGGAGATAAAGGCTATCCGGCCCCTTATCCCATCCCGGAGGAACATAAAGCCTGCTGGATGCTGCAACTGCTTTCGGCC
GAACCGCTGGGGAGAACGGGTCAGATACAGTGCGCTCGCGCGTTGATGAAACCCGAGCATTGGCGCGAGTAA