Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4576935..4577554 Replicon chromosome
Accession NZ_CP036175
Organism Klebsiella huaxiensis strain WCHKl090001

Toxin (Protein)


Gene name Hha Uniprot ID -
Locus tag DA718_RS21900 Protein ID WP_110273703.1
Coordinates 4577336..4577554 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag DA718_RS21895 Protein ID WP_112214173.1
Coordinates 4576935..4577309 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DA718_RS21885 4572091..4573284 + 1194 WP_112214175.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
DA718_RS21890 4573307..4576453 + 3147 WP_112214174.1 multidrug efflux RND transporter permease subunit AcrB -
DA718_RS21895 4576935..4577309 + 375 WP_112214173.1 Hha toxicity modulator TomB Antitoxin
DA718_RS21900 4577336..4577554 + 219 WP_110273703.1 hemolysin expression modulator Hha Toxin
DA718_RS21905 4577701..4578267 + 567 WP_112214172.1 maltose O-acetyltransferase -
DA718_RS21910 4578405..4578872 + 468 WP_112214171.1 YlaC family protein -
DA718_RS21915 4578850..4580304 - 1455 WP_112214170.1 PLP-dependent aminotransferase family protein -
DA718_RS21920 4580406..4581113 + 708 WP_112214169.1 GNAT family N-acetyltransferase -
DA718_RS21925 4581110..4581250 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
DA718_RS21930 4581250..4581513 - 264 WP_110273708.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8680.12 Da        Isoelectric Point: 8.9008

>T119248 WP_110273703.1 NZ_CP036175:4577336-4577554 [Klebsiella huaxiensis]
MSDKTLTKIDYLMRLRRCQTIDTLERVIEKNKYELPDNELTVFYSAADHRLAELTMNKLYDKIPPSVWKFIR

Download         Length: 219 bp

>T119248 NZ_CP036175:4577336-4577554 [Klebsiella huaxiensis]
ATGTCTGATAAAACATTAACCAAAATAGACTATTTGATGCGTTTACGACGCTGTCAGACAATTGATACGCTGGAACGCGT
AATTGAAAAAAACAAATATGAACTTCCCGATAATGAACTGACGGTATTTTACTCAGCAGCTGACCATCGTCTTGCTGAAT
TGACGATGAATAAACTGTACGACAAGATCCCTCCCTCAGTTTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14380.11 Da        Isoelectric Point: 4.8886

>AT119248 WP_112214173.1 NZ_CP036175:4576935-4577309 [Klebsiella huaxiensis]
MDEYSPKRHDIAQLKFLCETLYHDCLANLDESNHGWVNDPTSAVNLQLNELIEHIAAFALNYKIKYAEDNKLITQLDEYL
DDTFVLFSNYGINTTDLQKWRKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT119248 NZ_CP036175:4576935-4577309 [Klebsiella huaxiensis]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCGCAGCTTAAATTTCTCTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGATGAGAGCAACCATGGCTGGGTTAATGACCCGACTTCGGCTGTCAATCTTCAACTAAATGAATTGATCGAGC
ACATTGCCGCATTCGCACTTAATTATAAAATTAAGTATGCTGAGGATAATAAACTGATTACTCAGCTTGACGAATACCTG
GATGACACTTTCGTGCTGTTCAGCAACTACGGCATTAACACAACAGATCTACAGAAATGGCGCAAATCAGGCAACCGGTT
ATTTCGTTGCTTCGTGAACGCCAGTCGGGAAAACCCGGCAAGTCTTTCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References