Detailed information of TA system TA119239

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 1426039..1426822
• Replicon: chromosome
• Accession: NZ_CP036175
• Organism: Klebsiella huaxiensis strain WCHKl090001

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: DA718_RS06875
• Protein ID: WP_025107333.1
• Coordinates: 1426039..1426413 (-)
• Length: 125 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: DA718_RS06880
• Protein ID: WP_112216471.1
• Coordinates: 1426463..1426822 (-)
• Length: 120 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DA718_RS06855	1421707..1422405	+	699	WP_112216469.1	HNH endonuclease	-
DA718_RS06860	1423267..1423650	-	384	WP_112216470.1	hypothetical protein	-
DA718_RS06865	1424511..1425500	+	990	WP_025107331.1	glycosyltransferase	-
DA718_RS06870	1425639..1425959	+	321	WP_025107332.1	hypothetical protein	-
DA718_RS06875	1426039..1426413	-	375	WP_025107333.1	TA system toxin CbtA family protein	Toxin
DA718_RS06880	1426463..1426822	-	360	WP_112216471.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
DA718_RS06885	1426845..1427066	-	222	WP_025107335.1	DUF987 domain-containing protein	-
DA718_RS06890	1427080..1427562	-	483	WP_025107336.1	DNA repair protein RadC	-
DA718_RS06895	1427559..1427792	-	234	WP_025107337.1	hypothetical protein	-
DA718_RS06900	1427803..1428240	-	438	WP_032438904.1	antirestriction protein	-
DA718_RS06905	1428361..1429182	-	822	WP_025107339.1	DUF945 domain-containing protein	-
DA718_RS06910	1429289..1429501	-	213	WP_004136899.1	hypothetical protein	-
DA718_RS06915	1429587..1429946	-	360	WP_112216472.1	hypothetical protein	-
DA718_RS06920	1430001..1430465	-	465	WP_004136903.1	hypothetical protein	-
DA718_RS06925	1430742..1431410	-	669	Protein_1330	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1408777..1446177	37400
	-	flank	IS/Tn	-	-	1431554..1432534	980

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (8-112)

Antitoxin

• Antitoxin CbeA (15-114)

Sequences

Toxin

Protein

• Length: 125 a.a.
• Molecular weight: 13977.18 Da
• Isoelectric Point: 10.1897

>T119239 WP_025107333.1 NZ_CP036175:c1426413-1426039 [Klebsiella huaxiensis]
MQIHSLSLQRAASSRLSSVEIWRKLLMYLLKQHYGLMLNDTPFGNDEVIQKHIDAGISLCDAVNFIVEKYDLVRTDRHGF
SVKEQSPFIGSIDMLRARKATGLMTRKGYKTVTDITGGRFSGGK

Nucleotide

• Length: 375 bp

>T119239 NZ_CP036175:c1426413-1426039 [Klebsiella huaxiensis]
ATGCAAATACATTCCCTGTCCCTTCAAAGGGCGGCATCGTCACGTCTGTCGTCAGTCGAAATCTGGCGAAAATTACTGAT
GTATCTGCTGAAACAACACTACGGTCTGATGCTGAACGACACACCGTTTGGCAACGACGAAGTGATCCAGAAGCACATTG
ATGCGGGAATCTCACTGTGTGACGCGGTGAATTTTATCGTGGAAAAGTACGACCTGGTACGTACTGACCGTCACGGCTTC
AGCGTGAAAGAGCAGTCTCCGTTTATCGGTAGCATTGATATGCTCCGCGCCCGGAAGGCTACCGGGCTGATGACCCGCAA
GGGATATAAAACCGTTACTGACATCACAGGTGGCAGATTCAGCGGAGGGAAATAA

Antitoxin

Protein

• Length: 120 a.a.
• Molecular weight: 13440.59 Da
• Isoelectric Point: 7.7515

>AT119239 WP_112216471.1 NZ_CP036175:c1426822-1426463 [Klebsiella huaxiensis]
MQKATRVINHNITEPWWGLRRNITPCFGARLVQEGNHLHYLADRASIAGTFNDANLRHLDQVFPVLMKQMELMLASSELT
PRIQRCITLHVKGLICEADTLGSCGYLYIVIYPASATTE

Nucleotide

• Length: 360 bp

>AT119239 NZ_CP036175:c1426822-1426463 [Klebsiella huaxiensis]
ATGCAGAAAGCAACCCGTGTAATCAACCATAACATCACGGAACCCTGGTGGGGCCTCAGACGCAACATCACGCCGTGTTT
TGGTGCACGGCTGGTACAGGAGGGTAACCACCTGCATTACCTTGCTGACCGCGCCAGCATTGCCGGGACATTTAATGACG
CAAATTTACGCCATCTGGACCAGGTATTTCCGGTACTGATGAAGCAGATGGAGCTTATGCTGGCCAGCAGCGAACTCACG
CCCCGCATTCAGCGCTGCATCACGCTCCACGTAAAAGGGCTGATATGTGAGGCCGATACACTCGGCTCCTGCGGTTATTT
GTACATCGTAATTTATCCGGCGTCTGCAACAACCGAATAA