Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 496745..497398 Replicon chromosome
Accession NZ_CP036171
Organism Acinetobacter nosocomialis strain KAN02

Toxin (Protein)


Gene name cptA Uniprot ID A0A2T7FQV3
Locus tag KAN02_RS02410 Protein ID WP_025467795.1
Coordinates 497009..497398 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID N8SCE2
Locus tag KAN02_RS02405 Protein ID WP_002049719.1
Coordinates 496745..497002 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KAN02_RS02385 492259..493266 + 1008 WP_002049752.1 DNA-directed RNA polymerase subunit alpha -
KAN02_RS02390 493285..493662 + 378 WP_002049717.1 50S ribosomal protein L17 -
KAN02_RS02395 493844..495334 + 1491 WP_087606053.1 NAD(P)/FAD-dependent oxidoreductase -
KAN02_RS02400 495383..496555 - 1173 WP_002049748.1 acyl-CoA dehydrogenase family protein -
KAN02_RS02405 496745..497002 + 258 WP_002049719.1 succinate dehydrogenase assembly factor 2 Antitoxin
KAN02_RS02410 497009..497398 + 390 WP_025467795.1 hypothetical protein Toxin
KAN02_RS02415 498166..499251 + 1086 WP_087607115.1 hypothetical protein -
KAN02_RS02420 499335..499901 + 567 WP_004711824.1 rhombosortase -
KAN02_RS02425 500089..502284 + 2196 WP_087607116.1 TRAP transporter large permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15610.67 Da        Isoelectric Point: 10.0990

>T119236 WP_025467795.1 NZ_CP036171:497009-497398 [Acinetobacter nosocomialis]
MINHLNFKLKYSRFAIIFQFFIGLSLAVLFYQLLPILWWLVTVSLLFISFIFFLKRPQLAQIAHLDQKLWSLSFHSEQTI
SRVEILKIIDYQIFIVVYFEGHKTLTSVIWFDQMPLSQWKQLKTLEKFY

Download         Length: 390 bp

>T119236 NZ_CP036171:497009-497398 [Acinetobacter nosocomialis]
TTGATCAACCATTTGAATTTCAAACTGAAATATAGCCGTTTTGCGATTATATTTCAGTTTTTTATTGGCTTAAGTTTGGC
AGTTCTATTTTATCAACTCCTACCAATACTATGGTGGTTGGTTACGGTCAGTTTACTATTCATAAGTTTTATTTTCTTTT
TAAAGCGGCCACAGCTCGCTCAAATTGCTCATTTAGATCAAAAATTATGGTCACTTAGCTTTCATTCAGAACAAACAATT
TCTCGGGTAGAGATTTTAAAAATAATTGATTATCAGATTTTCATAGTGGTCTATTTTGAAGGGCATAAGACATTAACTTC
TGTTATTTGGTTTGATCAAATGCCTCTATCTCAGTGGAAACAACTTAAAACCTTAGAAAAATTTTATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10278.71 Da        Isoelectric Point: 4.7620

>AT119236 WP_002049719.1 NZ_CP036171:496745-497002 [Acinetobacter nosocomialis]
MSEEMTLEERKVVYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIHKLK
HYVHG

Download         Length: 258 bp

>AT119236 NZ_CP036171:496745-497002 [Acinetobacter nosocomialis]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAGTTTATCGCGCACGCCGCGGTTTAAAGGAAATTGATGTCTATTT
TGACCCGTATGTGAAAAATTATTATTTAAAGGCAGATCCAGCAGAAAAAGCATTATTTGCTGAATTGGTAGAGCAGGAAG
ATCCTGATTTACTTGACTGGTTTATGGAAGTATCTGAACCGCCACGTACAGAGTTACGTGATTTTATCCATAAATTAAAG
CATTATGTTCATGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2T7FQV3

Antitoxin

Source ID Structure
AlphaFold DB A0A0Q1QI86

References