Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-DinJ
Location 2323532..2324097 Replicon chromosome
Accession NZ_CP036170
Organism [Clostridium] scindens ATCC 35704

Toxin (Protein)


Gene name relE Uniprot ID B0NE10
Locus tag HDCHBGLK_RS12010 Protein ID WP_004606924.1
Coordinates 2323532..2323822 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A844F6Y3
Locus tag HDCHBGLK_RS12015 Protein ID WP_039909695.1
Coordinates 2323819..2324097 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HDCHBGLK_RS11980 2318930..2319616 + 687 Protein_2319 response regulator transcription factor -
HDCHBGLK_RS11985 2319613..2320476 + 864 WP_004606931.1 HAMP domain-containing histidine kinase -
HDCHBGLK_RS11990 2320587..2321117 + 531 WP_004606930.1 ABC transporter ATP-binding protein -
HDCHBGLK_RS11995 2321405..2321851 + 447 WP_004606929.1 hypothetical protein -
HDCHBGLK_RS12000 2321856..2322236 + 381 WP_004606928.1 sigma-70 family RNA polymerase sigma factor -
HDCHBGLK_RS19015 2322265..2322402 + 138 WP_004606927.1 hypothetical protein -
HDCHBGLK_RS12005 2322366..2323424 + 1059 Protein_2325 MobA/MobL family protein -
HDCHBGLK_RS12010 2323532..2323822 - 291 WP_004606924.1 type II toxin-antitoxin system YafQ family toxin Toxin
HDCHBGLK_RS12015 2323819..2324097 - 279 WP_039909695.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HDCHBGLK_RS19020 2324208..2324369 + 162 WP_004606922.1 hypothetical protein -
HDCHBGLK_RS12020 2324350..2324748 + 399 WP_039909694.1 cysteine-rich VLP domain-containing protein -
HDCHBGLK_RS19120 2324862..2325338 + 477 Protein_2330 phage replisome organizer N-terminal domain-containing protein -
HDCHBGLK_RS19125 2325339..2325980 + 642 WP_174722024.1 CHAP domain-containing protein -
HDCHBGLK_RS12030 2326121..2326828 + 708 WP_004606919.1 LytTR family DNA-binding domain-containing protein -
HDCHBGLK_RS12035 2326825..2328111 + 1287 WP_050755140.1 sensor histidine kinase -
HDCHBGLK_RS12040 2328288..2328974 + 687 WP_004606917.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(5-94)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-73)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11154.91 Da        Isoelectric Point: 8.0644

>T119235 WP_004606924.1 NZ_CP036170:c2323822-2323532 [[Clostridium] scindens ATCC 35704]
MRETKYTVKYTTSFKKDYKRAIKRGLKIELLEQIVALLAMGEPLPDKNRDHDLSGDWAGHRECHILPDWLLVYRIEDDVL
VLTLARTGTHSDLFGK

Download         Length: 291 bp

>T119235 NZ_CP036170:c2323822-2323532 [[Clostridium] scindens ATCC 35704]
ATGAGAGAAACCAAATATACCGTCAAGTACACGACTAGTTTCAAAAAAGACTACAAACGAGCCATAAAGCGTGGCTTGAA
GATCGAGCTGCTGGAGCAGATCGTAGCACTGCTGGCGATGGGCGAACCGCTGCCGGATAAGAACCGTGACCATGACCTGT
CCGGCGATTGGGCAGGACATCGGGAATGTCATATTCTCCCGGACTGGCTGCTTGTCTACCGCATAGAGGATGATGTTCTG
GTGCTGACGCTGGCCCGCACCGGCACACACAGCGACTTGTTCGGCAAATAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10233.64 Da        Isoelectric Point: 4.4692

>AT119235 WP_039909695.1 NZ_CP036170:c2324097-2323819 [[Clostridium] scindens ATCC 35704]
MAGNTTNISIRMDADLKAQADALFSELGMNLTTAFNIFVRQSLREGGIPFEVRLEQPNKETVAAMLEAERIAKDPSVKGY
NDLDELFADLKR

Download         Length: 279 bp

>AT119235 NZ_CP036170:c2324097-2323819 [[Clostridium] scindens ATCC 35704]
ATGGCTGGAAATACCACAAACATCAGTATCCGCATGGACGCAGATTTGAAAGCCCAGGCGGACGCACTGTTTTCGGAACT
TGGCATGAACCTGACTACGGCGTTTAACATCTTTGTGCGCCAGTCGCTTCGTGAGGGCGGCATTCCCTTTGAAGTAAGGC
TGGAACAGCCGAACAAAGAAACGGTTGCTGCCATGCTGGAAGCGGAAAGGATTGCAAAAGACCCGTCTGTAAAGGGCTAC
AATGACCTTGACGAGTTGTTTGCTGACCTGAAAAGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A844F3U5

Antitoxin

Source ID Structure
AlphaFold DB A0A844F6Y3

References