Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 463279..463841 Replicon chromosome
Accession NZ_CP036150
Organism Oceanispirochaeta crateris strain K2

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag EXM22_RS02095 Protein ID WP_149484923.1
Coordinates 463503..463841 (+) Length 113 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag EXM22_RS02090 Protein ID WP_149484922.1
Coordinates 463279..463509 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EXM22_RS02060 459147..459389 + 243 WP_149484917.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
EXM22_RS02065 459390..459650 + 261 WP_149484918.1 Txe/YoeB family addiction module toxin -
EXM22_RS02070 460069..460320 + 252 WP_210411536.1 type II toxin-antitoxin system RelE/ParE family toxin -
EXM22_RS02075 460307..460600 + 294 WP_149484920.1 helix-turn-helix transcriptional regulator -
EXM22_RS02080 460816..461628 + 813 WP_149484921.1 hypothetical protein -
EXM22_RS02085 461910..462875 + 966 WP_149484912.1 Fic family protein -
EXM22_RS02090 463279..463509 + 231 WP_149484922.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
EXM22_RS02095 463503..463841 + 339 WP_149484923.1 endoribonuclease MazF Toxin
EXM22_RS02100 464011..465000 + 990 WP_210411582.1 Fic family protein -
EXM22_RS02105 465475..467214 + 1740 WP_149484924.1 carbon starvation protein A -
EXM22_RS02110 467280..467720 + 441 WP_149484925.1 hypothetical protein -
EXM22_RS02115 467713..467997 + 285 WP_149484926.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-111)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 12543.66 Da        Isoelectric Point: 10.0377

>T119229 WP_149484923.1 NZ_CP036150:463503-463841 [Oceanispirochaeta crateris]
MVKKQYIPERGDIIWLNFTPQAGHEQAGKRPAIVISPSSYNSKTGLMIACPITSKIKNYPFEVPVIGRKISGVVLSDQVK
NLDWRVREAAFIEKATETAFSEVQEKLALLIK

Download         Length: 339 bp

>T119229 NZ_CP036150:463503-463841 [Oceanispirochaeta crateris]
CTGGTGAAAAAACAATATATACCTGAACGTGGAGACATAATCTGGCTAAATTTCACTCCTCAGGCCGGACATGAACAAGC
AGGAAAAAGACCAGCAATAGTTATTTCACCCTCTTCTTATAATTCTAAAACGGGGCTAATGATTGCTTGCCCAATTACGA
GTAAAATAAAAAACTACCCCTTCGAAGTACCGGTTATTGGAAGAAAAATATCAGGTGTTGTTTTATCAGATCAGGTAAAA
AACTTAGATTGGCGAGTTCGAGAAGCTGCATTTATTGAAAAAGCAACAGAAACTGCTTTTTCTGAAGTACAAGAAAAACT
CGCATTATTGATAAAATAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8731.91 Da        Isoelectric Point: 4.1712

>AT119229 WP_149484922.1 NZ_CP036150:463279-463509 [Oceanispirochaeta crateris]
MEAKIQKWGNSLGIRIPINIIRDLALENGSTVDIEEIEDRIIIKPKRNLEDLLSCITEENLHNEIDFGMPEGNESW

Download         Length: 231 bp

>AT119229 NZ_CP036150:463279-463509 [Oceanispirochaeta crateris]
ATGGAAGCAAAAATTCAGAAATGGGGCAATAGCCTAGGTATTCGTATTCCAATCAATATCATTCGTGATCTAGCACTGGA
AAACGGCTCAACTGTTGATATCGAAGAAATTGAAGATCGGATTATCATTAAACCAAAACGCAACCTCGAAGATTTATTAA
GTTGTATTACAGAAGAGAATTTACATAATGAAATCGATTTTGGTATGCCTGAAGGGAATGAATCCTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References