Detailed information of TA system TA119228

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/Txe-RelB
• Location: 459147..459650
• Replicon: chromosome
• Accession: NZ_CP036150
• Organism: Oceanispirochaeta crateris strain K2

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: EXM22_RS02065
• Protein ID: WP_149484918.1
• Coordinates: 459390..459650 (+)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: EXM22_RS02060
• Protein ID: WP_149484917.1
• Coordinates: 459147..459389 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EXM22_RS02035	454287..455252	+	966	WP_149484912.1	Fic family protein	-
EXM22_RS02040	455407..456420	+	1014	WP_149484913.1	hypothetical protein	-
EXM22_RS02045	456398..457420	+	1023	WP_149484914.1	hypothetical protein	-
EXM22_RS02050	457756..457956	+	201	WP_149484915.1	type II toxin-antitoxin system VapB family antitoxin	-
EXM22_RS02055	457953..458372	+	420	WP_149484916.1	PIN domain-containing protein	-
EXM22_RS02060	459147..459389	+	243	WP_149484917.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
EXM22_RS02065	459390..459650	+	261	WP_149484918.1	Txe/YoeB family addiction module toxin	Toxin
EXM22_RS02070	460069..460320	+	252	WP_210411536.1	type II toxin-antitoxin system RelE/ParE family toxin	-
EXM22_RS02075	460307..460600	+	294	WP_149484920.1	helix-turn-helix transcriptional regulator	-
EXM22_RS02080	460816..461628	+	813	WP_149484921.1	hypothetical protein	-
EXM22_RS02085	461910..462875	+	966	WP_149484912.1	Fic family protein	-
EXM22_RS02090	463279..463509	+	231	WP_149484922.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
EXM22_RS02095	463503..463841	+	339	WP_149484923.1	endoribonuclease MazF	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	436555..461628	25073

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (6-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-69)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10287.11 Da
• Isoelectric Point: 10.3349

>T119228 WP_149484918.1 NZ_CP036150:459390-459650 [Oceanispirochaeta crateris]
MFKLLYTKQAKKDARKLSESSLKKKAQQILEIIEVNPFQNPPPYEKLIGDLTGAYSRRINIQHRIVYQVLEKEQIVKILR
MWTHYE

Nucleotide

• Length: 261 bp

>T119228 NZ_CP036150:459390-459650 [Oceanispirochaeta crateris]
ATGTTCAAATTACTCTATACAAAACAAGCAAAAAAAGATGCAAGAAAGCTATCTGAAAGTAGTCTAAAAAAGAAAGCTCA
GCAGATATTAGAAATAATAGAAGTCAATCCATTCCAGAATCCACCCCCATATGAAAAACTGATTGGAGATTTAACAGGGG
CTTACTCAAGAAGAATAAATATTCAACATCGTATTGTATATCAAGTACTTGAAAAAGAACAAATAGTTAAAATATTAAGA
ATGTGGACACACTATGAATAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8980.16 Da
• Isoelectric Point: 4.4193

>AT119228 WP_149484917.1 NZ_CP036150:459147-459389 [Oceanispirochaeta crateris]
MSSINVTNARKDLYKIVETVNLSHEPVHITGKNSSAVLIGEDDWKSIEETLHLMSIPGMRESIIKGMNTPIDELDDSLDW

Nucleotide

• Length: 243 bp

>AT119228 NZ_CP036150:459147-459389 [Oceanispirochaeta crateris]
ATGAGTTCAATTAATGTAACAAATGCAAGGAAAGATCTGTATAAAATTGTTGAAACTGTCAATTTATCTCATGAACCTGT
ACATATAACAGGAAAAAACAGCTCTGCTGTTTTAATAGGAGAGGATGACTGGAAGAGCATTGAAGAAACGCTTCATCTCA
TGTCCATACCAGGCATGAGAGAATCTATCATTAAAGGAATGAATACTCCAATAGATGAATTAGATGATTCTTTGGATTGG
TAA