Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /SpoIISA(toxin) |
| Location | 2342609..2343587 | Replicon | chromosome |
| Accession | NZ_CP036132 | ||
| Organism | Bacillus mycoides strain JAS823 | ||
Toxin (Protein)
| Gene name | spoIISA | Uniprot ID | - |
| Locus tag | EXW56_RS11870 | Protein ID | WP_215558483.1 |
| Coordinates | 2342609..2343349 (+) | Length | 247 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | R8HWP4 |
| Locus tag | EXW56_RS11875 | Protein ID | WP_000588712.1 |
| Coordinates | 2343462..2343587 (+) | Length | 42 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EXW56_RS11845 (EXW56_12080) | 2338678..2339388 | + | 711 | WP_215558479.1 | class I SAM-dependent methyltransferase | - |
| EXW56_RS11850 (EXW56_12085) | 2339508..2339921 | + | 414 | WP_215558480.1 | VOC family protein | - |
| EXW56_RS11855 (EXW56_12090) | 2340162..2340794 | - | 633 | WP_204209219.1 | type 1 glutamine amidotransferase family protein | - |
| EXW56_RS11860 (EXW56_12095) | 2341055..2341531 | + | 477 | WP_204209218.1 | MarR family winged helix-turn-helix transcriptional regulator | - |
| EXW56_RS11865 (EXW56_12100) | 2341685..2342422 | + | 738 | WP_215597511.1 | 2,3-diphosphoglycerate-dependent phosphoglycerate mutase | - |
| EXW56_RS11870 (EXW56_12105) | 2342609..2343349 | + | 741 | WP_215558483.1 | type II toxin-antitoxin system SpoIISA family toxin | Toxin |
| EXW56_RS11875 (EXW56_12110) | 2343462..2343587 | + | 126 | WP_000588712.1 | hypothetical protein | Antitoxin |
| EXW56_RS11880 | 2343663..2343839 | + | 177 | WP_002200471.1 | stage II sporulation protein SB | - |
| EXW56_RS11885 (EXW56_12115) | 2344016..2345485 | + | 1470 | WP_204209215.1 | aminoacyl-histidine dipeptidase | - |
| EXW56_RS11890 (EXW56_12120) | 2345628..2346437 | + | 810 | WP_204209214.1 | papain-like cysteine protease family protein | - |
| EXW56_RS11895 (EXW56_12125) | 2346465..2346942 | + | 478 | Protein_2274 | hypothetical protein | - |
| EXW56_RS11900 (EXW56_12130) | 2347309..2348490 | + | 1182 | WP_002200467.1 | agmatine deiminase family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 247 a.a. Molecular weight: 28308.82 Da Isoelectric Point: 7.3943
>T119223 WP_215558483.1 NZ_CP036132:2342609-2343349 [Bacillus mycoides]
MTISNIRIGLFILAIVFIVLVFFYWKNEELYEEKKQRIRKTWYGLFITSVTVYFTIKGIDLTLWKNLLMFTAMVIFVDIA
FILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAAFGTMEWHTEEEYTKSLNAFLDSYGEKVGAK
IVVFEAVNELNTNFRGIRSQFSITVPLEHIEQLNGQQAVQVENVGIIPAKIVNDVFIVIDGKKNNLQDRDFENVYNLTIH
HSYFSK
MTISNIRIGLFILAIVFIVLVFFYWKNEELYEEKKQRIRKTWYGLFITSVTVYFTIKGIDLTLWKNLLMFTAMVIFVDIA
FILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAAFGTMEWHTEEEYTKSLNAFLDSYGEKVGAK
IVVFEAVNELNTNFRGIRSQFSITVPLEHIEQLNGQQAVQVENVGIIPAKIVNDVFIVIDGKKNNLQDRDFENVYNLTIH
HSYFSK
Download Length: 741 bp
>T119223 NZ_CP036132:2342609-2343349 [Bacillus mycoides]
TTGACGATCTCTAACATTCGAATCGGCTTATTTATTTTAGCAATCGTCTTTATTGTTCTTGTTTTCTTTTATTGGAAAAA
TGAAGAATTGTATGAGGAGAAGAAACAGCGAATTCGAAAAACGTGGTACGGTTTGTTCATAACATCAGTCACAGTTTATT
TCACGATAAAAGGAATAGATTTAACCCTCTGGAAAAATCTTTTAATGTTTACTGCGATGGTAATTTTCGTTGATATTGCA
TTCATTTTGACACCTAACATTTCAGAAATATGGGGTGCAAAATTCAGTGATATCGGAAAGACGGTCCAATCAATTAAACG
GTCATTAATTGCTTCAAAAGCAAGAGGAGAAATATATACGACAATTATTCAAAATGTAAATCCAGCAGCATTTGGGACAA
TGGAATGGCACACGGAAGAAGAATATACAAAAAGTTTAAACGCATTTCTTGATTCGTATGGTGAAAAAGTAGGTGCGAAA
ATTGTTGTATTTGAAGCAGTGAACGAATTAAATACGAATTTCCGTGGTATTCGCTCTCAATTTAGTATTACAGTACCTCT
AGAACATATAGAGCAATTGAATGGCCAGCAAGCGGTTCAAGTAGAAAATGTCGGAATTATACCAGCAAAAATAGTGAATG
ATGTTTTTATTGTTATTGATGGGAAGAAGAATAACCTTCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATACAT
CATAGTTATTTTAGTAAATAA
TTGACGATCTCTAACATTCGAATCGGCTTATTTATTTTAGCAATCGTCTTTATTGTTCTTGTTTTCTTTTATTGGAAAAA
TGAAGAATTGTATGAGGAGAAGAAACAGCGAATTCGAAAAACGTGGTACGGTTTGTTCATAACATCAGTCACAGTTTATT
TCACGATAAAAGGAATAGATTTAACCCTCTGGAAAAATCTTTTAATGTTTACTGCGATGGTAATTTTCGTTGATATTGCA
TTCATTTTGACACCTAACATTTCAGAAATATGGGGTGCAAAATTCAGTGATATCGGAAAGACGGTCCAATCAATTAAACG
GTCATTAATTGCTTCAAAAGCAAGAGGAGAAATATATACGACAATTATTCAAAATGTAAATCCAGCAGCATTTGGGACAA
TGGAATGGCACACGGAAGAAGAATATACAAAAAGTTTAAACGCATTTCTTGATTCGTATGGTGAAAAAGTAGGTGCGAAA
ATTGTTGTATTTGAAGCAGTGAACGAATTAAATACGAATTTCCGTGGTATTCGCTCTCAATTTAGTATTACAGTACCTCT
AGAACATATAGAGCAATTGAATGGCCAGCAAGCGGTTCAAGTAGAAAATGTCGGAATTATACCAGCAAAAATAGTGAATG
ATGTTTTTATTGTTATTGATGGGAAGAAGAATAACCTTCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATACAT
CATAGTTATTTTAGTAAATAA
Antitoxin
Download Length: 42 a.a. Molecular weight: 4938.34 Da Isoelectric Point: 3.9150
>AT119223 WP_000588712.1 NZ_CP036132:2343462-2343587 [Bacillus mycoides]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK
Download Length: 126 bp
>AT119223 NZ_CP036132:2343462-2343587 [Bacillus mycoides]
GTGATAAAAGATTATGACAATGATTTTTTTAAAGAAGATAATGAAGATACAACAGATTTTTCTTTAATAAAAGGAGATAC
TTTGCAGCAAGTGGAAGAGTTAGAAGAAGAATTAAAAAGAAAATGA
GTGATAAAAGATTATGACAATGATTTTTTTAAAGAAGATAATGAAGATACAACAGATTTTTCTTTAATAAAAGGAGATAC
TTTGCAGCAAGTGGAAGAGTTAGAAGAAGAATTAAAAAGAAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|