Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /SpoIISA(toxin) |
| Location | 2084846..2085824 | Replicon | chromosome |
| Accession | NZ_CP036121 | ||
| Organism | Bacillus mycoides strain JAS635 | ||
Toxin (Protein)
| Gene name | spoIISA | Uniprot ID | A0A2S9I2K6 |
| Locus tag | EXW55_RS10580 | Protein ID | WP_002189615.1 |
| Coordinates | 2084846..2085586 (+) | Length | 247 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | J8YSJ3 |
| Locus tag | EXW55_RS10585 | Protein ID | WP_002069312.1 |
| Coordinates | 2085699..2085824 (+) | Length | 42 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EXW55_RS10550 (EXW55_10735) | 2079944..2080705 | + | 762 | WP_016120207.1 | ABC transporter ATP-binding protein | - |
| EXW55_RS10555 (EXW55_10740) | 2080812..2081522 | + | 711 | WP_002189612.1 | class I SAM-dependent methyltransferase | - |
| EXW55_RS10560 (EXW55_10745) | 2081641..2082054 | + | 414 | WP_002012925.1 | VOC family protein | - |
| EXW55_RS10565 (EXW55_10750) | 2082231..2082863 | - | 633 | WP_098635011.1 | type 1 glutamine amidotransferase family protein | - |
| EXW55_RS10570 (EXW55_10755) | 2083137..2083613 | + | 477 | WP_002017049.1 | MarR family winged helix-turn-helix transcriptional regulator | - |
| EXW55_RS10575 (EXW55_10760) | 2083767..2084504 | + | 738 | WP_002032137.1 | 2,3-diphosphoglycerate-dependent phosphoglycerate mutase | - |
| EXW55_RS10580 (EXW55_10765) | 2084846..2085586 | + | 741 | WP_002189615.1 | type II toxin-antitoxin system SpoIISA family toxin | Toxin |
| EXW55_RS10585 (EXW55_10770) | 2085699..2085824 | + | 126 | WP_002069312.1 | hypothetical protein | Antitoxin |
| EXW55_RS10590 | 2085901..2086077 | + | 177 | WP_002189619.1 | stage II sporulation protein SB | - |
| EXW55_RS10595 (EXW55_10775) | 2086096..2086485 | - | 390 | WP_002189620.1 | YxeA family protein | - |
| EXW55_RS10600 (EXW55_10780) | 2086703..2088172 | + | 1470 | WP_098635012.1 | beta-Ala-His dipeptidase | - |
| EXW55_RS10605 (EXW55_10785) | 2088821..2090050 | - | 1230 | WP_215560414.1 | collagen-like protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 247 a.a. Molecular weight: 28477.20 Da Isoelectric Point: 8.3034
>T119220 WP_002189615.1 NZ_CP036121:2084846-2085586 [Bacillus mycoides]
MVISNIRIGLFILAIIFVVLVFFYWRNEELYEEKKQRIRKTWYGLFITSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIA
FILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTNIIQNINPAAFGTMEWHTEEEYTKSLNAFLDSYGEKIGAK
IVVFEAVKELNTNFRGIRSQFSIIVPLEHIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIH
HSYFSK
MVISNIRIGLFILAIIFVVLVFFYWRNEELYEEKKQRIRKTWYGLFITSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIA
FILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTNIIQNINPAAFGTMEWHTEEEYTKSLNAFLDSYGEKIGAK
IVVFEAVKELNTNFRGIRSQFSIIVPLEHIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIH
HSYFSK
Download Length: 741 bp
>T119220 NZ_CP036121:2084846-2085586 [Bacillus mycoides]
TTGGTAATCTCTAACATTCGAATCGGCTTATTTATTTTAGCGATCATTTTTGTAGTTCTTGTTTTCTTTTATTGGAGAAA
TGAAGAGTTATACGAAGAGAAAAAGCAGCGAATTCGAAAAACTTGGTATGGATTATTCATAACATCAGTCACAGTTTATT
TCATGATAAAAGGAATCGATTTAACCCTCTGGAAAAACTTATTAATGTTTACTGCGATGGTCATTTTCGTTGATATTGCA
TTTATTTTAACACCTAACATTTCTGAAATATGGGGAGCGAAATTTAGCGATATCGGTAAAACTGTTCAATCCATAAAGCG
GTCATTAATCGCCTCAAAAGCAAGAGGAGAAATATATACGAACATTATCCAAAATATTAATCCAGCAGCATTTGGGACGA
TGGAATGGCATACGGAAGAGGAATATACAAAAAGCTTAAACGCATTTTTAGATTCATATGGGGAAAAAATTGGAGCGAAA
ATTGTTGTATTTGAAGCGGTGAAGGAATTAAATACAAACTTTCGTGGTATCCGCTCTCAATTTAGTATTATTGTTCCATT
AGAACACATCGAGCAATTGAATGAGCAGAAAGCGGTGCAAGTAGAAAATGTCGGAATTATACCAGCAAAAATAGTTAGTG
ATGTTTTCATTGTTATTGATGGGAAGAAAAATAACCTTCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATTCAT
CATAGTTATTTTAGTAAATAA
TTGGTAATCTCTAACATTCGAATCGGCTTATTTATTTTAGCGATCATTTTTGTAGTTCTTGTTTTCTTTTATTGGAGAAA
TGAAGAGTTATACGAAGAGAAAAAGCAGCGAATTCGAAAAACTTGGTATGGATTATTCATAACATCAGTCACAGTTTATT
TCATGATAAAAGGAATCGATTTAACCCTCTGGAAAAACTTATTAATGTTTACTGCGATGGTCATTTTCGTTGATATTGCA
TTTATTTTAACACCTAACATTTCTGAAATATGGGGAGCGAAATTTAGCGATATCGGTAAAACTGTTCAATCCATAAAGCG
GTCATTAATCGCCTCAAAAGCAAGAGGAGAAATATATACGAACATTATCCAAAATATTAATCCAGCAGCATTTGGGACGA
TGGAATGGCATACGGAAGAGGAATATACAAAAAGCTTAAACGCATTTTTAGATTCATATGGGGAAAAAATTGGAGCGAAA
ATTGTTGTATTTGAAGCGGTGAAGGAATTAAATACAAACTTTCGTGGTATCCGCTCTCAATTTAGTATTATTGTTCCATT
AGAACACATCGAGCAATTGAATGAGCAGAAAGCGGTGCAAGTAGAAAATGTCGGAATTATACCAGCAAAAATAGTTAGTG
ATGTTTTCATTGTTATTGATGGGAAGAAAAATAACCTTCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATTCAT
CATAGTTATTTTAGTAAATAA
Antitoxin
Download Length: 42 a.a. Molecular weight: 4937.36 Da Isoelectric Point: 3.9798
>AT119220 WP_002069312.1 NZ_CP036121:2085699-2085824 [Bacillus mycoides]
VIKDYDNDFFKENNEDTTDFSLIKGDTLQQVEELEEELKRK
VIKDYDNDFFKENNEDTTDFSLIKGDTLQQVEELEEELKRK
Download Length: 126 bp
>AT119220 NZ_CP036121:2085699-2085824 [Bacillus mycoides]
GTGATAAAAGATTATGACAATGATTTTTTTAAAGAAAATAATGAAGATACAACAGATTTCTCTTTAATAAAAGGAGATAC
TTTGCAGCAAGTAGAAGAGTTAGAAGAAGAATTAAAAAGAAAATGA
GTGATAAAAGATTATGACAATGATTTTTTTAAAGAAAATAATGAAGATACAACAGATTTCTCTTTAATAAAAGGAGATAC
TTTGCAGCAAGTAGAAGAGTTAGAAGAAGAATTAAAAAGAAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2S9I2K6 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | J8YSJ3 |