Detailed information of TA system TA119208

Bioinformatically predicted

Overview

TA module

• Type: III
• Classification (family/domain): toxIN/ToxN(toxin)
• Location: 12914..13645
• Replicon: plasmid unnamed4
• Accession: NZ_CP036105
• Organism: Bacillus mycoides strain JAS391

Toxin (Protein)

• Gene name: toxN
• Uniprot ID: -
• Locus tag: EXW34_RS29880
• Protein ID: WP_215601451.1
• Coordinates: 13073..13645 (+)
• Length: 191 a.a.

Antitoxin (RNA)

Gene name	toxI
Locus tag	-
Coordinates	12914..13010 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EXW34_RS29855 (8122)	8122..8331	+	210	WP_016078858.1	DUF5511 family protein	-
EXW34_RS29860 (8328)	8328..10097	+	1770	WP_215601447.1	ArdC-like ssDNA-binding domain-containing protein	-
EXW34_RS29865 (10161)	10161..11147	+	987	WP_215601448.1	hypothetical protein	-
EXW34_RS29870 (11169)	11169..11720	+	552	WP_215601449.1	metal-dependent hydrolase	-
EXW34_RS29875 (11800)	11800..12825	+	1026	WP_215601450.1	DUF3991 and TOPRIM domain-containing protein	-
- (12914)	12914..13010	+	97	NuclAT_0	-	Antitoxin
- (12914)	12914..13010	+	97	NuclAT_0	-	Antitoxin
- (12914)	12914..13010	+	97	NuclAT_0	-	Antitoxin
- (12914)	12914..13010	+	97	NuclAT_0	-	Antitoxin
EXW34_RS29880 (13073)	13073..13645	+	573	WP_215601451.1	type III toxin-antitoxin system ToxN/AbiQ family toxin	Toxin
EXW34_RS29885 (14032)	14032..16173	+	2142	WP_215601452.1	type IA DNA topoisomerase	-
EXW34_RS29890 (16203)	16203..16649	+	447	WP_215601453.1	CPBP family intramembrane metalloprotease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..109920	109920

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• ToxN/AbiQ toxin (8-171)

Sequences

Toxin

Protein

• Length: 191 a.a.
• Molecular weight: 22341.67 Da
• Isoelectric Point: 9.6407

>T119208 WP_215601451.1 NZ_CP036105:13073-13645 [Bacillus mycoides]
MANKDNPKFYTISTKYIDYLRETDSKVPFNKDEQHSRPYVGVLEKINGHDYFVPLTSRNDKNFNSQVSVKLFDNDNPEKR
IGVLLINNMIPVPEKECKEIDIAEKKAADPKYGNLMLKQYLFLKENMDRVSNKVEKIYKDVSVQGKPSQKQKFIKGVCCD
FPKLEGKCQEYKERDQARRIAYMRQMGRER

Nucleotide

• Length: 573 bp

>T119208 NZ_CP036105:13073-13645 [Bacillus mycoides]
TTGGCTAATAAAGATAATCCTAAATTTTACACTATTTCAACTAAATATATAGACTATCTAAGAGAAACAGATAGTAAAGT
ACCCTTTAATAAAGATGAACAGCATAGCAGACCGTATGTAGGCGTATTGGAAAAAATCAATGGTCATGATTATTTTGTGC
CTTTAACATCACGTAATGATAAAAATTTTAATAGTCAGGTCAGTGTAAAATTATTCGATAACGATAACCCTGAGAAGCGA
ATTGGAGTTTTATTAATAAATAACATGATTCCAGTCCCAGAAAAAGAGTGTAAAGAAATTGATATAGCAGAAAAAAAGGC
GGCAGACCCTAAGTATGGTAATTTGATGTTAAAGCAGTATTTGTTTTTAAAAGAGAATATGGATAGAGTGTCTAATAAAG
TAGAAAAAATATATAAAGATGTATCTGTACAAGGGAAGCCTTCACAAAAACAGAAATTCATTAAAGGCGTTTGTTGTGAT
TTCCCTAAATTAGAAGGAAAATGCCAAGAATATAAAGAAAGAGATCAAGCTAGAAGGATAGCATATATGCGCCAAATGGG
GCGTGAGAGATAA

Antitoxin

Nucleotide

• Length: 97 bp

>AT119208 NZ_CP036105:12914-13010 [Bacillus mycoides]
GTAGCCTTACTTTAGTAGGCGCGAAAAAATTGGTGTAACTCTACCGTAGTGAGTACCAAAAAATTGGTGTAGCCTTACCG
TAGTAGGCGCAAAAAAA

Structures

Antitoxin