119207

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2373659..2374637 Replicon chromosome
Accession NZ_CP036102
Organism Bacillus mycoides strain JAS391

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A2S9I2K6
Locus tag EXW34_RS11990 Protein ID WP_002189615.1
Coordinates 2373659..2374399 (+) Length 247 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID J8YSJ3
Locus tag EXW34_RS11995 Protein ID WP_002069312.1
Coordinates 2374512..2374637 (+) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EXW34_RS11960 (EXW34_12205) 2368860..2369621 + 762 WP_033728066.1 ABC transporter ATP-binding protein -
EXW34_RS11965 (EXW34_12210) 2369728..2370438 + 711 WP_002189612.1 class I SAM-dependent methyltransferase -
EXW34_RS11970 (EXW34_12215) 2370557..2370970 + 414 WP_002012925.1 VOC family protein -
EXW34_RS11975 (EXW34_12220) 2371147..2371779 - 633 WP_002189613.1 type 1 glutamine amidotransferase family protein -
EXW34_RS11980 (EXW34_12225) 2372053..2372529 + 477 WP_002017049.1 MarR family winged helix-turn-helix transcriptional regulator -
EXW34_RS11985 (EXW34_12230) 2372683..2373420 + 738 WP_002189614.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
EXW34_RS11990 (EXW34_12235) 2373659..2374399 + 741 WP_002189615.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
EXW34_RS11995 (EXW34_12240) 2374512..2374637 + 126 WP_002069312.1 hypothetical protein Antitoxin
EXW34_RS12000 (EXW34_12245) 2374713..2374889 + 177 WP_002141782.1 stage II sporulation protein SB -
EXW34_RS12005 (EXW34_12250) 2374933..2375208 - 276 WP_002141783.1 hypothetical protein -
EXW34_RS12010 (EXW34_12255) 2375235..2375765 - 531 WP_002189617.1 hypothetical protein -
EXW34_RS12015 2376087..2376263 + 177 WP_002189619.1 stage II sporulation protein SB -
EXW34_RS12020 (EXW34_12260) 2376282..2376671 - 390 WP_002189620.1 YxeA family protein -
EXW34_RS12025 (EXW34_12265) 2376889..2378358 + 1470 WP_002189621.1 beta-Ala-His dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(10-244)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 247 a.a.        Molecular weight: 28477.20 Da        Isoelectric Point: 8.3034

>T119207 WP_002189615.1 NZ_CP036102:2373659-2374399 [Bacillus mycoides]
MVISNIRIGLFILAIIFVVLVFFYWRNEELYEEKKQRIRKTWYGLFITSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIA
FILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTNIIQNINPAAFGTMEWHTEEEYTKSLNAFLDSYGEKIGAK
IVVFEAVKELNTNFRGIRSQFSIIVPLEHIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIH
HSYFSK

Download         Length: 741 bp

>T119207 NZ_CP036102:2373659-2374399 [Bacillus mycoides]
TTGGTAATCTCTAACATTCGAATCGGCTTATTTATTTTAGCGATCATTTTTGTAGTTCTTGTTTTCTTTTATTGGAGAAA
TGAAGAGTTATACGAAGAGAAAAAGCAGCGAATTCGAAAAACTTGGTATGGATTATTCATAACATCAGTCACAGTTTATT
TCATGATAAAAGGAATCGATTTAACCCTCTGGAAAAACTTATTAATGTTTACTGCGATGGTCATTTTCGTTGATATTGCA
TTTATTTTAACACCTAACATTTCTGAAATATGGGGAGCGAAATTTAGCGATATCGGTAAAACTGTTCAATCCATAAAGCG
GTCATTAATCGCCTCAAAAGCAAGAGGAGAAATATATACGAACATTATCCAAAATATTAATCCAGCAGCATTTGGGACGA
TGGAATGGCATACGGAAGAGGAATATACAAAAAGCTTAAACGCATTTTTAGATTCATATGGGGAAAAAATTGGAGCGAAA
ATTGTTGTATTTGAAGCGGTGAAGGAATTAAATACAAACTTTCGTGGTATCCGCTCTCAATTTAGTATTATTGTTCCATT
AGAACACATCGAGCAATTGAATGAGCAGAAAGCGGTGCAAGTAGAAAATGTCGGAATTATACCAGCAAAAATAGTTAGTG
ATGTTTTCATTGTTATTGATGGGAAGAAAAATAACCTTCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATTCAT
CATAGTTATTTTAGTAAATAA

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4937.36 Da        Isoelectric Point: 3.9798

>AT119207 WP_002069312.1 NZ_CP036102:2374512-2374637 [Bacillus mycoides]
VIKDYDNDFFKENNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp

>AT119207 NZ_CP036102:2374512-2374637 [Bacillus mycoides]
GTGATAAAAGATTATGACAATGATTTTTTTAAAGAAAATAATGAAGATACAACAGATTTCTCTTTAATAAAAGGAGATAC
TTTGCAGCAAGTAGAAGAGTTAGAAGAAGAATTAAAAAGAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S9I2K6

Antitoxin

Source ID Structure
AlphaFold DB J8YSJ3

References