Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /SpoIISA(toxin) |
| Location | 2382912..2383890 | Replicon | chromosome |
| Accession | NZ_CP036094 | ||
| Organism | Bacillus toyonensis strain JAS22/1 | ||
Toxin (Protein)
| Gene name | spoIISA | Uniprot ID | K0FNW8 |
| Locus tag | EXW54_RS12085 | Protein ID | WP_000155917.1 |
| Coordinates | 2382912..2383652 (+) | Length | 247 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | J8KE32 |
| Locus tag | EXW54_RS12090 | Protein ID | WP_000588713.1 |
| Coordinates | 2383765..2383890 (+) | Length | 42 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EXW54_RS12065 (EXW54_12355) | 2378572..2379354 | + | 783 | WP_000381781.1 | class I SAM-dependent methyltransferase | - |
| EXW54_RS12070 (EXW54_12360) | 2379535..2381211 | - | 1677 | WP_000857155.1 | alpha-keto acid decarboxylase family protein | - |
| EXW54_RS12075 (EXW54_12365) | 2381338..2381820 | + | 483 | WP_000191892.1 | MarR family winged helix-turn-helix transcriptional regulator | - |
| EXW54_RS12080 (EXW54_12370) | 2381988..2382725 | + | 738 | WP_000594132.1 | 2,3-diphosphoglycerate-dependent phosphoglycerate mutase | - |
| EXW54_RS12085 (EXW54_12375) | 2382912..2383652 | + | 741 | WP_000155917.1 | type II toxin-antitoxin system SpoIISA family toxin | Toxin |
| EXW54_RS12090 (EXW54_12380) | 2383765..2383890 | + | 126 | WP_000588713.1 | hypothetical protein | Antitoxin |
| EXW54_RS12095 (EXW54_12385) | 2383966..2384142 | + | 177 | WP_000808012.1 | stage II sporulation protein SB | - |
| EXW54_RS12100 (EXW54_12390) | 2384191..2384580 | - | 390 | WP_000732294.1 | YxeA family protein | - |
| EXW54_RS12105 (EXW54_12395) | 2384824..2386293 | + | 1470 | WP_000287565.1 | beta-Ala-His dipeptidase | - |
| EXW54_RS12110 (EXW54_12400) | 2386604..2387413 | + | 810 | WP_000678381.1 | papain-like cysteine protease family protein | - |
| EXW54_RS12115 (EXW54_12405) | 2387441..2388043 | + | 603 | WP_000517300.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 247 a.a. Molecular weight: 28446.03 Da Isoelectric Point: 7.3946
>T119201 WP_000155917.1 NZ_CP036094:2382912-2383652 [Bacillus toyonensis]
MTISNIRIGLFILAIVFVVLVFFYWRNEELYEEKKQRIRKTWYGLFITSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIS
FILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTNIIQNINPAAFGTMEWHTEEEYTKSLNTFLDSYGEKIGAK
IVVFEAANELNTGFRGIRSQFSITIPIEHIEQLNEQKAVQVENVGIIPAKIMNDVFIVIDGKKNSLQDRDFENVYNLTIH
HSYFSK
MTISNIRIGLFILAIVFVVLVFFYWRNEELYEEKKQRIRKTWYGLFITSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIS
FILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTNIIQNINPAAFGTMEWHTEEEYTKSLNTFLDSYGEKIGAK
IVVFEAANELNTGFRGIRSQFSITIPIEHIEQLNEQKAVQVENVGIIPAKIMNDVFIVIDGKKNSLQDRDFENVYNLTIH
HSYFSK
Download Length: 741 bp
>T119201 NZ_CP036094:2382912-2383652 [Bacillus toyonensis]
TTGACGATCTCTAACATTCGAATTGGCTTATTTATTTTAGCAATCGTTTTTGTAGTTCTTGTTTTCTTTTATTGGAGAAA
TGAAGAGTTGTATGAAGAGAAAAAGCAGCGAATTCGAAAAACTTGGTATGGATTATTCATAACATCAGTCACAGTTTATT
TCATGATTAAAGGAATCGATTTAACCCTCTGGAAAAATTTATTAATGTTCACTGCGATGGTCATTTTCGTTGATATTTCA
TTTATTTTAACACCTAACATTTCGGAAATATGGGGAGCGAAATTTAGCGATATCGGTAAAACTGTTCAATCCATAAAGCG
GTCATTAATCGCTTCAAAAGCAAGAGGGGAAATATATACGAACATTATCCAAAATATTAATCCAGCAGCATTTGGGACGA
TGGAATGGCATACGGAAGAGGAATATACAAAAAGCTTAAACACATTTTTAGATTCATATGGGGAAAAAATCGGAGCGAAA
ATTGTTGTATTTGAAGCAGCGAATGAATTAAATACGGGCTTTCGTGGTATTCGTTCTCAATTTAGTATTACAATACCTAT
AGAGCATATAGAGCAATTGAATGAACAAAAAGCAGTACAAGTAGAAAACGTGGGAATTATACCAGCAAAAATAATGAATG
ATGTTTTTATCGTTATTGATGGGAAGAAGAATAGCCTGCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATACAT
CATAGTTATTTTAGTAAGTAG
TTGACGATCTCTAACATTCGAATTGGCTTATTTATTTTAGCAATCGTTTTTGTAGTTCTTGTTTTCTTTTATTGGAGAAA
TGAAGAGTTGTATGAAGAGAAAAAGCAGCGAATTCGAAAAACTTGGTATGGATTATTCATAACATCAGTCACAGTTTATT
TCATGATTAAAGGAATCGATTTAACCCTCTGGAAAAATTTATTAATGTTCACTGCGATGGTCATTTTCGTTGATATTTCA
TTTATTTTAACACCTAACATTTCGGAAATATGGGGAGCGAAATTTAGCGATATCGGTAAAACTGTTCAATCCATAAAGCG
GTCATTAATCGCTTCAAAAGCAAGAGGGGAAATATATACGAACATTATCCAAAATATTAATCCAGCAGCATTTGGGACGA
TGGAATGGCATACGGAAGAGGAATATACAAAAAGCTTAAACACATTTTTAGATTCATATGGGGAAAAAATCGGAGCGAAA
ATTGTTGTATTTGAAGCAGCGAATGAATTAAATACGGGCTTTCGTGGTATTCGTTCTCAATTTAGTATTACAATACCTAT
AGAGCATATAGAGCAATTGAATGAACAAAAAGCAGTACAAGTAGAAAACGTGGGAATTATACCAGCAAAAATAATGAATG
ATGTTTTTATCGTTATTGATGGGAAGAAGAATAGCCTGCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATACAT
CATAGTTATTTTAGTAAGTAG
Antitoxin
Download Length: 42 a.a. Molecular weight: 4951.43 Da Isoelectric Point: 4.1079
>AT119201 WP_000588713.1 NZ_CP036094:2383765-2383890 [Bacillus toyonensis]
VIKDYDNDFFKEENEDTTDFSLIKGDTLQQVEKLEEELKRK
VIKDYDNDFFKEENEDTTDFSLIKGDTLQQVEKLEEELKRK
Download Length: 126 bp
>AT119201 NZ_CP036094:2383765-2383890 [Bacillus toyonensis]
GTGATAAAAGATTATGACAATGATTTTTTTAAAGAAGAAAATGAAGATACAACAGATTTCTCTTTAATCAAAGGAGATAC
GTTGCAGCAAGTAGAAAAGTTAGAAGAAGAATTAAAAAGAAAATGA
GTGATAAAAGATTATGACAATGATTTTTTTAAAGAAGAAAATGAAGATACAACAGATTTCTCTTTAATCAAAGGAGATAC
GTTGCAGCAAGTAGAAAAGTTAGAAGAAGAATTAAAAAGAAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|