Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /SpoIISA(toxin) |
| Location | 2437097..2438075 | Replicon | chromosome |
| Accession | NZ_CP036090 | ||
| Organism | Bacillus toyonensis strain JAS13/1 | ||
Toxin (Protein)
| Gene name | spoIISA | Uniprot ID | A0A2B4WYW4 |
| Locus tag | EXW29_RS12330 | Protein ID | WP_000155915.1 |
| Coordinates | 2437097..2437837 (+) | Length | 247 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | J8KE32 |
| Locus tag | EXW29_RS12335 | Protein ID | WP_000588713.1 |
| Coordinates | 2437950..2438075 (+) | Length | 42 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EXW29_RS12310 (EXW29_12525) | 2432759..2433541 | + | 783 | WP_097954109.1 | class I SAM-dependent methyltransferase | - |
| EXW29_RS12315 (EXW29_12530) | 2433720..2435396 | - | 1677 | WP_215595959.1 | alpha-keto acid decarboxylase family protein | - |
| EXW29_RS12320 (EXW29_12535) | 2435523..2436005 | + | 483 | WP_000196695.1 | MarR family winged helix-turn-helix transcriptional regulator | - |
| EXW29_RS12325 (EXW29_12540) | 2436173..2436910 | + | 738 | WP_097954107.1 | 2,3-diphosphoglycerate-dependent phosphoglycerate mutase | - |
| EXW29_RS12330 (EXW29_12545) | 2437097..2437837 | + | 741 | WP_000155915.1 | type II toxin-antitoxin system SpoIISA family toxin | Toxin |
| EXW29_RS12335 (EXW29_12550) | 2437950..2438075 | + | 126 | WP_000588713.1 | hypothetical protein | Antitoxin |
| EXW29_RS12340 (EXW29_12555) | 2438151..2438327 | + | 177 | WP_000808012.1 | stage II sporulation protein SB | - |
| EXW29_RS12345 (EXW29_12560) | 2438376..2438764 | - | 389 | Protein_2369 | YxeA family protein | - |
| EXW29_RS12350 (EXW29_12565) | 2439008..2440486 | + | 1479 | WP_097954106.1 | beta-Ala-His dipeptidase | - |
| EXW29_RS12355 (EXW29_12570) | 2440799..2441608 | + | 810 | WP_097954105.1 | papain-like cysteine protease family protein | - |
| EXW29_RS12360 (EXW29_12575) | 2441636..2442238 | + | 603 | WP_097954104.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 247 a.a. Molecular weight: 28416.00 Da Isoelectric Point: 7.3946
>T119199 WP_000155915.1 NZ_CP036090:2437097-2437837 [Bacillus toyonensis]
MTISNIRIGLFILAIVFVVLVFFYWRNEELYEEKKQRIRKTWYGLFITSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIS
FILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTNIIQNINPAAFGTMEWHTEEEYTKSLNAFLDSYGEKIGAK
IVVFEAANELNTGFRGIRSQFSITIPIEHIEQLNEQKAVQVENVGIIPAKIMNDVFIVIDGKKNSLQDRDFENVYNLTIH
HSYFSK
MTISNIRIGLFILAIVFVVLVFFYWRNEELYEEKKQRIRKTWYGLFITSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIS
FILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTNIIQNINPAAFGTMEWHTEEEYTKSLNAFLDSYGEKIGAK
IVVFEAANELNTGFRGIRSQFSITIPIEHIEQLNEQKAVQVENVGIIPAKIMNDVFIVIDGKKNSLQDRDFENVYNLTIH
HSYFSK
Download Length: 741 bp
>T119199 NZ_CP036090:2437097-2437837 [Bacillus toyonensis]
TTGACGATCTCTAACATTCGAATTGGCTTATTTATTTTAGCAATCGTTTTTGTAGTTCTTGTTTTCTTTTATTGGAGAAA
TGAAGAGTTATATGAAGAGAAAAAGCAGCGAATTCGAAAAACTTGGTATGGATTATTCATAACATCAGTCACAGTTTATT
TCATGATTAAAGGAATCGATTTAACCCTCTGGAAAAACTTATTAATGTTCACTGCGATGGTCATTTTTGTTGATATTTCA
TTTATTTTAACACCTAATATTTCCGAAATATGGGGAGCGAAATTTAGCGATATCGGTAAAACTGTTCAATCCATAAAGCG
GTCATTAATCGCTTCAAAAGCAAGAGGAGAAATATATACGAACATTATCCAAAATATTAATCCAGCAGCATTTGGGACGA
TGGAATGGCATACGGAAGAGGAATATACAAAAAGCTTAAACGCATTTTTAGATTCATACGGGGAAAAAATTGGAGCGAAA
ATCGTTGTATTTGAAGCAGCGAATGAATTAAATACGGGCTTTCGTGGTATTCGTTCTCAATTTAGTATTACAATACCTAT
AGAGCATATAGAGCAATTGAATGAACAAAAAGCAGTGCAAGTAGAAAACGTGGGAATTATACCAGCAAAAATAATGAATG
ATGTTTTTATCGTGATTGATGGGAAGAAGAATAGCCTGCAGGATCGAGATTTTGAAAATGTCTATAATTTAACAATACAT
CATAGTTATTTTAGTAAGTAG
TTGACGATCTCTAACATTCGAATTGGCTTATTTATTTTAGCAATCGTTTTTGTAGTTCTTGTTTTCTTTTATTGGAGAAA
TGAAGAGTTATATGAAGAGAAAAAGCAGCGAATTCGAAAAACTTGGTATGGATTATTCATAACATCAGTCACAGTTTATT
TCATGATTAAAGGAATCGATTTAACCCTCTGGAAAAACTTATTAATGTTCACTGCGATGGTCATTTTTGTTGATATTTCA
TTTATTTTAACACCTAATATTTCCGAAATATGGGGAGCGAAATTTAGCGATATCGGTAAAACTGTTCAATCCATAAAGCG
GTCATTAATCGCTTCAAAAGCAAGAGGAGAAATATATACGAACATTATCCAAAATATTAATCCAGCAGCATTTGGGACGA
TGGAATGGCATACGGAAGAGGAATATACAAAAAGCTTAAACGCATTTTTAGATTCATACGGGGAAAAAATTGGAGCGAAA
ATCGTTGTATTTGAAGCAGCGAATGAATTAAATACGGGCTTTCGTGGTATTCGTTCTCAATTTAGTATTACAATACCTAT
AGAGCATATAGAGCAATTGAATGAACAAAAAGCAGTGCAAGTAGAAAACGTGGGAATTATACCAGCAAAAATAATGAATG
ATGTTTTTATCGTGATTGATGGGAAGAAGAATAGCCTGCAGGATCGAGATTTTGAAAATGTCTATAATTTAACAATACAT
CATAGTTATTTTAGTAAGTAG
Antitoxin
Download Length: 42 a.a. Molecular weight: 4951.43 Da Isoelectric Point: 4.1079
>AT119199 WP_000588713.1 NZ_CP036090:2437950-2438075 [Bacillus toyonensis]
VIKDYDNDFFKEENEDTTDFSLIKGDTLQQVEKLEEELKRK
VIKDYDNDFFKEENEDTTDFSLIKGDTLQQVEKLEEELKRK
Download Length: 126 bp
>AT119199 NZ_CP036090:2437950-2438075 [Bacillus toyonensis]
GTGATAAAAGATTATGACAATGATTTTTTCAAAGAAGAAAATGAAGATACAACAGATTTCTCTTTAATCAAAGGAGATAC
GTTGCAGCAAGTAGAAAAGTTAGAAGAAGAATTAAAAAGAAAATGA
GTGATAAAAGATTATGACAATGATTTTTTCAAAGAAGAAAATGAAGATACAACAGATTTCTCTTTAATCAAAGGAGATAC
GTTGCAGCAAGTAGAAAAGTTAGAAGAAGAATTAAAAAGAAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2B4WYW4 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | J8KE32 |