Detailed information of TA system TA119191

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /SpoIISA(toxin)
• Location: 2362187..2363162
• Replicon: chromosome
• Accession: NZ_CP036070
• Organism: Bacillus wiedmannii strain JAS07/5

Toxin (Protein)

• Gene name: spoIISA
• Uniprot ID: -
• Locus tag: EXW41_RS12070
• Protein ID: WP_142291738.1
• Coordinates: 2362187..2362924 (+)
• Length: 246 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: R8HWP4
• Locus tag: EXW41_RS12075
• Protein ID: WP_000588712.1
• Coordinates: 2363037..2363162 (+)
• Length: 42 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EXW41_RS12050 (EXW41_12130)	2357859..2358641	+	783	WP_088063378.1	class I SAM-dependent methyltransferase	-
EXW41_RS12055 (EXW41_12135)	2358818..2360503	-	1686	WP_088063379.1	alpha-keto acid decarboxylase family protein	-
EXW41_RS12060 (EXW41_12140)	2360611..2361093	+	483	WP_088063380.1	MarR family winged helix-turn-helix transcriptional regulator	-
EXW41_RS12065 (EXW41_12145)	2361261..2361998	+	738	WP_088063381.1	2,3-diphosphoglycerate-dependent phosphoglycerate mutase	-
EXW41_RS12070 (EXW41_12150)	2362187..2362924	+	738	WP_142291738.1	type II toxin-antitoxin system SpoIISA family toxin	Toxin
EXW41_RS12075 (EXW41_12155)	2363037..2363162	+	126	WP_000588712.1	hypothetical protein	Antitoxin
EXW41_RS12080	2363238..2363414	+	177	WP_046959435.1	stage II sporulation protein SB	-
EXW41_RS12085 (EXW41_12160)	2363433..2363822	-	390	WP_060488821.1	YxeA family protein	-
EXW41_RS12090 (EXW41_12165)	2364039..2365508	+	1470	WP_088063383.1	beta-Ala-His dipeptidase	-
EXW41_RS12095 (EXW41_12170)	2366098..2366568	-	471	WP_088063384.1	DUF5065 family protein	-
EXW41_RS12100 (EXW41_12175)	2367022..2367681	+	660	WP_088063385.1	CatB-related O-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SpoIISA, type II toxin-antitoxin system (9-243)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 246 a.a.
• Molecular weight: 28397.12 Da
• Isoelectric Point: 8.3034

>T119191 WP_142291738.1 NZ_CP036070:2362187-2362924 [Bacillus wiedmannii]
VISNIRIGLFILAIVFLVLVFFYWRNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAMFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSIIVPFEHIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Nucleotide

• Length: 738 bp

>T119191 NZ_CP036070:2362187-2362924 [Bacillus wiedmannii]
GTGATCTCTAACATTCGAATCGGCTTATTTATTTTAGCAATCGTTTTTCTCGTTCTTGTGTTCTTTTACTGGAGAAACGA
AGAGTTGTACGAGGAGAAAAAGCAACGTATTAGAAAGACTTGGTATGGGTTGTTTATAATATCAGTCACTGTGTATTTCA
TGATAAAAGGAATTGATTTAACCCTCTGGAAAAACCTATTAATGTTCACTGCAATGGTTATTTTCGTTGATATCGCATTT
ATTTTAACACCTAATATTTCCGAAATATGGGGAGCGAAATTTAGCGATATCGGCAAGACTGTTCAATCGATAAAACGGTC
TTTAATTGCTTCTAAAGCAAGAGGGGAAATATATACAACAATTATTCAAAATGTCAATCCAGCAATGTTCGGTACAATGG
AATGGCATACGGAAGAAGAGTATACAAAAAGCTTAAACGCATTTTTAGATTCGTATGGGGAAAAGATTGGTGCGAAAATT
GTCGTATTTGAAGCGGCAAAGGAATTAAATACTAACTTTCGCGGTATCCGTTCTCAATTTAGTATTATCGTTCCGTTTGA
ACACATTGAGCAGTTGAATGAGCAGAAAGCGGTACAAGTAGAAAATGTCGGCATTATACCAGCAAAAATTGTGAGTGATG
TTTTCATTGTTATTGATGGGAAGAAAAATAATCTGCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA

Antitoxin

Protein

• Length: 42 a.a.
• Molecular weight: 4938.34 Da
• Isoelectric Point: 3.9150

>AT119191 WP_000588712.1 NZ_CP036070:2363037-2363162 [Bacillus wiedmannii]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Nucleotide

• Length: 126 bp

>AT119191 NZ_CP036070:2363037-2363162 [Bacillus wiedmannii]
GTGATAAAAGATTATGACAATGATTTTTTTAAAGAAGATAATGAAGATACAACAGATTTCTCGTTAATAAAAGGAGATAC
ATTACAGCAAGTAGAAGAGTTAGAAGAAGAATTAAAAAGAAAATGA

Structures

Antitoxin

• AlphaFold DB: A0A366GQT1