Detailed information of TA system TA119184

Bioinformatically predicted

Overview

TA module

• Type: III
• Classification (family/domain): toxIN/ToxN(toxin)
• Location: 15863..16594
• Replicon: plasmid p88
• Accession: NZ_CP036059
• Organism: Bacillus mycoides strain JAS06/1

Toxin (Protein)

• Gene name: toxN
• Uniprot ID: -
• Locus tag: EXW44_RS29990
• Protein ID: WP_043331257.1
• Coordinates: 16022..16594 (+)
• Length: 191 a.a.

Antitoxin (RNA)

Gene name	toxI
Locus tag	-
Coordinates	15863..15959 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EXW44_RS29965 (11071)	11071..11280	+	210	WP_016078858.1	DUF5511 family protein	-
EXW44_RS29970 (11277)	11277..13046	+	1770	WP_215564673.1	ArdC-like ssDNA-binding domain-containing protein	-
EXW44_RS29975 (13110)	13110..14096	+	987	WP_215564675.1	hypothetical protein	-
EXW44_RS29980 (14118)	14118..14669	+	552	WP_215564677.1	metal-dependent hydrolase	-
EXW44_RS29985 (14749)	14749..15774	+	1026	WP_088038698.1	DUF3991 and TOPRIM domain-containing protein	-
- (15863)	15863..15959	+	97	NuclAT_0	-	Antitoxin
- (15863)	15863..15959	+	97	NuclAT_0	-	Antitoxin
- (15863)	15863..15959	+	97	NuclAT_0	-	Antitoxin
- (15863)	15863..15959	+	97	NuclAT_0	-	Antitoxin
EXW44_RS29990 (16022)	16022..16594	+	573	WP_043331257.1	type III toxin-antitoxin system ToxN/AbiQ family toxin	Toxin
EXW44_RS29995 (16981)	16981..19122	+	2142	WP_215564679.1	type IA DNA topoisomerase	-
EXW44_RS30000 (19152)	19152..19604	+	453	WP_215564681.1	CPBP family intramembrane metalloprotease	-
EXW44_RS30005 (19791)	19791..20105	-	315	WP_215564683.1	hypothetical protein	-
EXW44_RS30010 (20756)	20756..20914	+	159	Protein_24	CPBP family intramembrane metalloprotease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..87819	87819

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• ToxN/AbiQ toxin (8-171)

Sequences

Toxin

Protein

• Length: 191 a.a.
• Molecular weight: 22314.60 Da
• Isoelectric Point: 9.5226

>T119184 WP_043331257.1 NZ_CP036059:16022-16594 [Bacillus mycoides]
MANKDNPKFYTISTKYIDYLRETDSKVPFNKDEQHSRPYVGVLEKINGHDYFVPLTSRNDKNFNSQVSVKLFDNDNPEKR
IGVLLINNMIPVPEKECKEIDIAEKTAADPKYGNLMLKQYLFLKENMDRVSNKVEKIYKDVSVQGKPSQKQKFIKGVCCD
FPKLEGKCQEYKERDQARRIAYMRQMGRER

Nucleotide

• Length: 573 bp

>T119184 NZ_CP036059:16022-16594 [Bacillus mycoides]
TTGGCTAATAAAGATAATCCTAAATTTTACACTATTTCAACTAAATATATAGACTATCTAAGAGAAACAGATAGTAAAGT
ACCCTTTAATAAAGATGAACAGCATAGCAGACCGTATGTAGGCGTATTGGAAAAAATCAATGGTCATGATTATTTTGTGC
CTTTAACATCACGTAATGATAAAAATTTTAATAGTCAGGTCAGTGTAAAATTATTCGATAACGATAACCCTGAGAAGCGA
ATTGGAGTTTTATTAATAAATAACATGATTCCAGTCCCAGAAAAAGAGTGTAAAGAAATTGATATAGCAGAAAAAACGGC
GGCAGACCCTAAGTATGGTAATTTGATGTTAAAGCAGTATTTGTTTTTAAAAGAGAATATGGATCGAGTGTCTAATAAAG
TAGAAAAAATATATAAAGATGTATCTGTACAAGGGAAGCCTTCACAAAAACAGAAATTCATTAAAGGAGTTTGTTGTGAT
TTCCCTAAATTAGAAGGAAAATGCCAAGAATATAAAGAAAGAGATCAAGCTAGAAGGATAGCATATATGCGCCAAATGGG
GCGTGAGAGATAA

Antitoxin

Nucleotide

• Length: 97 bp

>AT119184 NZ_CP036059:15863-15959 [Bacillus mycoides]
GTAGCCTTACTTTAGTAGGCGCGAAAAAATTGGTGTAACTCTACCGTAGTGAGTACCAAAAAATTGGTGTAGCCTTACCG
TAGTAGGCGCAAAAAAA

Structures

Antitoxin