119182

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2155098..2156076 Replicon chromosome
Accession NZ_CP036057
Organism Bacillus mycoides strain JAS06/1

Toxin (Protein)


Gene name spoIISA Uniprot ID J8I6P2
Locus tag EXW44_RS10950 Protein ID WP_002017051.1
Coordinates 2155098..2155838 (+) Length 247 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag EXW44_RS10955 Protein ID WP_000588712.1
Coordinates 2155951..2156076 (+) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EXW44_RS10920 (EXW44_11085) 2150200..2150961 + 762 WP_002127420.1 ABC transporter ATP-binding protein -
EXW44_RS10925 (EXW44_11090) 2151067..2151777 + 711 WP_002127421.1 class I SAM-dependent methyltransferase -
EXW44_RS10930 (EXW44_11095) 2151896..2152309 + 414 WP_002012925.1 VOC family protein -
EXW44_RS10935 (EXW44_11100) 2152486..2153118 - 633 WP_002017047.1 type 1 glutamine amidotransferase family protein -
EXW44_RS10940 (EXW44_11105) 2153392..2153868 + 477 WP_002017049.1 MarR family winged helix-turn-helix transcriptional regulator -
EXW44_RS10945 (EXW44_11110) 2154022..2154759 + 738 WP_002032137.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
EXW44_RS10950 (EXW44_11115) 2155098..2155838 + 741 WP_002017051.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
EXW44_RS10955 (EXW44_11120) 2155951..2156076 + 126 WP_000588712.1 hypothetical protein Antitoxin
EXW44_RS10960 2156152..2156328 + 177 WP_003189253.1 stage II sporulation protein SB -
EXW44_RS10965 (EXW44_11125) 2156349..2156738 - 390 WP_215564340.1 YxeA family protein -
EXW44_RS10970 (EXW44_11130) 2156990..2158459 + 1470 WP_016126945.1 aminoacyl-histidine dipeptidase -
EXW44_RS10975 2158819..2158968 + 150 WP_002069316.1 hypothetical protein -
EXW44_RS10980 (EXW44_11135) 2159682..2160341 + 660 WP_003189261.1 CatB-related O-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(10-244)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 247 a.a.        Molecular weight: 28512.20 Da        Isoelectric Point: 8.3034

>T119182 WP_002017051.1 NZ_CP036057:2155098-2155838 [Bacillus mycoides]
MTISNIRIGLFILAIVFIVLVFFYWRNEELYEEKKQRIRKTWYGLFITSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIA
FILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPTAFGTMEWHTEEEYTKSLNTFLDSYGEKIGAK
IVVFEAVKELNTNFRGIRSQFSIIVPLEHIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIH
HSYFSK

Download         Length: 741 bp

>T119182 NZ_CP036057:2155098-2155838 [Bacillus mycoides]
TTGACGATCTCTAACATTCGAATTGGCTTATTTATTTTAGCAATCGTCTTTATTGTTCTTGTTTTCTTTTATTGGAGAAA
TGAAGAGTTGTACGAGGAGAAGAAACAACGAATTCGAAAAACGTGGTACGGTTTGTTCATAACATCAGTCACAGTTTATT
TCATGATAAAAGGAATAGATTTAACCCTCTGGAAAAATCTTTTAATGTTTACTGCGATGGTAATTTTCGTTGATATTGCA
TTCATTTTGACACCAAATATTTCAGAAATATGGGGCGCAAAATTCAGCGATATTGGAAAGACGGTCCAATCAATTAAAAG
GTCATTAATTGCTTCAAAAGCAAGAGGAGAAATATATACGACAATTATTCAAAATGTGAATCCAACAGCCTTTGGGACAA
TGGAATGGCATACGGAAGAGGAATATACAAAAAGCTTAAACACATTTTTAGATTCATATGGGGAAAAGATTGGTGCGAAA
ATTGTTGTATTTGAAGCGGTGAAGGAATTAAATACAAACTTTCGTGGTATCCGCTCTCAATTTAGTATTATTGTTCCATT
AGAACACATCGAGCAATTGAATGAGCAGAAAGCGGTGCAAGTAGAAAATGTCGGAATTATACCAGCAAAAATAGTTAGTG
ATGTTTTCATTGTTATTGATGGGAAGAAAAATAACCTTCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATTCAT
CATAGTTATTTTAGTAAATAA

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT119182 WP_000588712.1 NZ_CP036057:2155951-2156076 [Bacillus mycoides]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp

>AT119182 NZ_CP036057:2155951-2156076 [Bacillus mycoides]
GTGATAAAAGATTATGACAATGATTTTTTTAAAGAAGATAATGAAGATACAACAGATTTCTCTTTAATAAAAGGAGATAC
TTTGCAGCAAGTAGAAGAGTTAGAAGAAGAATTAAAAAGAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB J8I6P2

Antitoxin

Source ID Structure
AlphaFold DB A0A366GQT1

References