Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2384159..2385137 Replicon chromosome
Accession NZ_CP036040
Organism Bacillus mycoides strain BPN573

Toxin (Protein)


Gene name spoIISA Uniprot ID -
Locus tag EXW50_RS12095 Protein ID WP_201065725.1
Coordinates 2384159..2384899 (+) Length 247 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag EXW50_RS12100 Protein ID WP_215552300.1
Coordinates 2385012..2385137 (+) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EXW50_RS12070 (EXW50_12350) 2380148..2380858 + 711 WP_215552302.1 class I SAM-dependent methyltransferase -
EXW50_RS12075 (EXW50_12355) 2380978..2381391 + 414 WP_215552301.1 VOC family protein -
EXW50_RS12080 (EXW50_12360) 2381568..2382200 - 633 WP_002017047.1 type 1 glutamine amidotransferase family protein -
EXW50_RS12085 (EXW50_12365) 2382474..2382950 + 477 WP_002017049.1 MarR family winged helix-turn-helix transcriptional regulator -
EXW50_RS12090 (EXW50_12370) 2383104..2383841 + 738 WP_002032137.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
EXW50_RS12095 (EXW50_12375) 2384159..2384899 + 741 WP_201065725.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
EXW50_RS12100 (EXW50_12380) 2385012..2385137 + 126 WP_215552300.1 D-alanyl-D-alanine carboxypeptidase Antitoxin
EXW50_RS12105 2385213..2385389 + 177 WP_002017052.1 stage II sporulation protein SB -
EXW50_RS12110 (EXW50_12385) 2385409..2385777 - 369 WP_215553103.1 YxeA family protein -
EXW50_RS12115 (EXW50_12390) 2386048..2387517 + 1470 WP_215552299.1 aminoacyl-histidine dipeptidase -
EXW50_RS12120 2387877..2388026 + 150 WP_002069316.1 hypothetical protein -
EXW50_RS12125 (EXW50_12395) 2388782..2389441 + 660 WP_215552298.1 CatB-related O-acetyltransferase -
EXW50_RS29255 2389636..2389784 + 149 Protein_2325 bacitracin ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(10-244)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 247 a.a.        Molecular weight: 28509.14 Da        Isoelectric Point: 8.3034

>T119175 WP_201065725.1 NZ_CP036040:2384159-2384899 [Bacillus mycoides]
MTISNIRIGLFILAIVFIVLVFFYWRNEELYEEKKQRIRKTWYGLFITSVTVYFTIKGIDLTLWKNLLMFTAMVIFVDIA
FILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPTAFGTMEWHTEEEYTKNLNTFLDSYGEKIGAK
IVVFEAVKELNTNFRGIRSQFSIIVPLEHIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIH
HSYFSK

Download         Length: 741 bp

>T119175 NZ_CP036040:2384159-2384899 [Bacillus mycoides]
TTGACGATCTCTAACATTCGAATTGGCTTATTTATTTTAGCAATCGTCTTTATTGTTCTTGTTTTCTTTTATTGGAGAAA
TGAAGAGTTGTACGAGGAGAAGAAACAACGAATTCGAAAAACGTGGTACGGTTTGTTCATAACATCAGTCACAGTTTATT
TCACGATAAAAGGAATAGATTTAACCCTCTGGAAAAATCTTTTAATGTTTACTGCGATGGTAATTTTCGTTGATATTGCA
TTCATTTTGACACCAAATATTTCAGAAATATGGGGCGCAAAATTCAGCGATATTGGAAAGACGGTCCAATCAATTAAAAG
GTCATTAATTGCTTCAAAAGCAAGAGGAGAAATATATACGACAATTATTCAAAATGTGAATCCAACAGCCTTTGGGACAA
TGGAATGGCATACGGAAGAGGAATATACAAAAAACTTAAACACATTTTTAGATTCATATGGGGAAAAGATTGGTGCGAAA
ATTGTTGTATTTGAAGCGGTGAAGGAATTAAATACAAACTTTCGTGGTATCCGCTCTCAATTTAGTATTATTGTTCCATT
AGAACATATCGAGCAATTGAATGAGCAGAAAGCGGTGCAAGTAGAAAATGTCGGAATTATACCAGCAAAAATAGTTAGTG
ATGTTTTCATTGTTATTGATGGGAAGAAAAATAACCTTCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATTCAT
CATAGTTATTTTAGTAAATAA

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4939.33 Da        Isoelectric Point: 3.8705

>AT119175 WP_215552300.1 NZ_CP036040:2385012-2385137 [Bacillus mycoides]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLEQVEELEEELKRK

Download         Length: 126 bp

>AT119175 NZ_CP036040:2385012-2385137 [Bacillus mycoides]
GTGATAAAAGATTATGACAATGATTTTTTTAAAGAAGATAATGAAGATACAACAGATTTCTCTTTAATAAAAGGAGATAC
TTTGGAGCAAGTAGAAGAGTTAGAAGAAGAATTAAAAAGAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References