Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2262271..2263249 Replicon chromosome
Accession NZ_CP036034
Organism Bacillus mycoides strain BPN57/2

Toxin (Protein)


Gene name spoIISA Uniprot ID -
Locus tag EXW62_RS11455 Protein ID WP_286675795.1
Coordinates 2262271..2263011 (+) Length 247 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag EXW62_RS11460 Protein ID WP_000588712.1
Coordinates 2263124..2263249 (+) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EXW62_RS11430 (EXW62_11675) 2258241..2258951 + 711 WP_215556358.1 class I SAM-dependent methyltransferase -
EXW62_RS11435 (EXW62_11680) 2259070..2259483 + 414 WP_002012925.1 VOC family protein -
EXW62_RS11440 (EXW62_11685) 2259660..2260292 - 633 WP_215556359.1 type 1 glutamine amidotransferase family protein -
EXW62_RS11445 (EXW62_11690) 2260566..2261042 + 477 WP_215556360.1 MarR family winged helix-turn-helix transcriptional regulator -
EXW62_RS11450 (EXW62_11695) 2261196..2261933 + 738 WP_215556361.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
EXW62_RS11455 (EXW62_11700) 2262271..2263011 + 741 WP_286675795.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
EXW62_RS11460 (EXW62_11705) 2263124..2263249 + 126 WP_000588712.1 hypothetical protein Antitoxin
EXW62_RS11465 (EXW62_11710) 2263325..2263504 + 180 WP_215556362.1 stage II sporulation protein SB -
EXW62_RS11470 (EXW62_11715) 2263681..2265150 + 1470 WP_215556363.1 aminoacyl-histidine dipeptidase -
EXW62_RS11475 (EXW62_11720) 2265762..2266232 - 471 WP_215556364.1 DUF5065 family protein -
EXW62_RS11480 (EXW62_11725) 2266686..2267345 + 660 WP_215556365.1 CatB-related O-acetyltransferase -
EXW62_RS11485 2267852..2268007 + 156 WP_215556366.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(10-244)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 247 a.a.        Molecular weight: 28488.28 Da        Isoelectric Point: 8.3034

>T119169 WP_286675795.1 NZ_CP036034:2262271-2263011 [Bacillus mycoides]
MTISNIRIGLFILAMAFVVLVFFYWRNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIA
FILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEMYTTIIQNVNPAAFGTMEWHMEEEYTKSLNAFLDSYGEKIGAK
IVVFEAVKELNTNFRGIRSQFSIIVPLEHIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIH
HSYFSK

Download         Length: 741 bp

>T119169 NZ_CP036034:2262271-2263011 [Bacillus mycoides]
TTGACGATCTCTAACATTCGAATCGGTTTATTTATTCTAGCAATGGCCTTTGTAGTTCTTGTTTTCTTTTATTGGAGAAA
TGAAGAGTTGTACGAGGAGAAGAAACAACGAATTCGAAAAACTTGGTATGGTTTGTTTATAATATCAGTCACAGTTTATT
TCATGATAAAAGGAATAGATTTAACCCTCTGGAAAAATCTTTTAATGTTCACTGCGATGGTAATTTTCGTTGATATTGCA
TTTATTTTGACACCTAATATTTCAGAAATATGGGGCGCAAAATTCAGCGATATTGGAAAGACGGTCCAATCAATTAAAAG
GTCATTAATTGCTTCAAAAGCAAGAGGAGAAATGTATACGACAATTATTCAAAATGTGAATCCAGCAGCCTTTGGGACAA
TGGAATGGCATATGGAAGAGGAGTATACAAAAAGCTTAAACGCATTTTTAGATTCATATGGGGAAAAGATTGGTGCGAAA
ATTGTTGTATTTGAAGCGGTGAAGGAATTAAATACAAACTTTCGTGGTATCCGCTCTCAATTTAGTATTATTGTTCCATT
AGAACACATCGAGCAATTGAATGAGCAGAAAGCGGTGCAAGTAGAAAATGTCGGAATTATACCAGCGAAAATAGTTAGTG
ATGTTTTCATTGTTATTGATGGGAAGAAAAATAACCTTCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATTCAT
CATAGTTATTTTAGTAAATAA

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT119169 WP_000588712.1 NZ_CP036034:2263124-2263249 [Bacillus mycoides]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp

>AT119169 NZ_CP036034:2263124-2263249 [Bacillus mycoides]
GTGATAAAAGATTATGACAATGATTTTTTTAAAGAAGATAATGAAGATACAACAGATTTCTCTTTAATAAAAGGAGATAC
TTTGCAGCAAGTAGAAGAGTTAGAAGAAGAATTAAAAAGAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A366GQT1

References