Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /SpoIISA(toxin) |
| Location | 2379578..2380551 | Replicon | chromosome |
| Accession | NZ_CP036026 | ||
| Organism | Bacillus mycoides strain BPN54/2 | ||
Toxin (Protein)
| Gene name | spoIISA | Uniprot ID | - |
| Locus tag | EXW38_RS12370 | Protein ID | WP_215570491.1 |
| Coordinates | 2379578..2380318 (+) | Length | 247 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | R8HWP4 |
| Locus tag | EXW38_RS12375 | Protein ID | WP_000588712.1 |
| Coordinates | 2380426..2380551 (+) | Length | 42 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EXW38_RS12340 (EXW38_12490) | 2374595..2375356 | + | 762 | WP_215572850.1 | ABC transporter ATP-binding protein | - |
| EXW38_RS12345 (EXW38_12495) | 2375463..2376173 | + | 711 | WP_078182016.1 | class I SAM-dependent methyltransferase | - |
| EXW38_RS12350 (EXW38_12500) | 2376292..2376705 | + | 414 | WP_016104868.1 | VOC family protein | - |
| EXW38_RS12355 (EXW38_12505) | 2376946..2377578 | - | 633 | WP_002161789.1 | type 1 glutamine amidotransferase family protein | - |
| EXW38_RS12360 (EXW38_12510) | 2377853..2378335 | + | 483 | WP_215572851.1 | MarR family winged helix-turn-helix transcriptional regulator | - |
| EXW38_RS12365 (EXW38_12515) | 2378503..2379240 | + | 738 | WP_131232117.1 | 2,3-diphosphoglycerate-dependent phosphoglycerate mutase | - |
| EXW38_RS12370 (EXW38_12520) | 2379578..2380318 | + | 741 | WP_215570491.1 | type II toxin-antitoxin system SpoIISA family toxin | Toxin |
| EXW38_RS12375 (EXW38_12525) | 2380426..2380551 | + | 126 | WP_000588712.1 | hypothetical protein | Antitoxin |
| EXW38_RS12380 (EXW38_12530) | 2380627..2380803 | + | 177 | WP_002141782.1 | stage II sporulation protein SB | - |
| EXW38_RS12385 (EXW38_12535) | 2380847..2381122 | - | 276 | WP_215572852.1 | hypothetical protein | - |
| EXW38_RS30580 | 2381149..2381943 | - | 795 | WP_234879579.1 | hypothetical protein | - |
| EXW38_RS12395 (EXW38_12545) | 2381993..2382793 | - | 801 | WP_215570493.1 | hypothetical protein | - |
| EXW38_RS12400 (EXW38_12550) | 2382786..2382968 | - | 183 | WP_215572977.1 | hypothetical protein | - |
| EXW38_RS12405 | 2383290..2383466 | + | 177 | WP_002141786.1 | stage II sporulation protein SB | - |
| EXW38_RS12410 (EXW38_12555) | 2383542..2383923 | - | 382 | Protein_2376 | YxeA family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 247 a.a. Molecular weight: 28436.15 Da Isoelectric Point: 8.3034
>T119167 WP_215570491.1 NZ_CP036026:2379578-2380318 [Bacillus mycoides]
MVISNIRIGLFILAIIFVVLVFFYWRNEELYEEKKQRIRKTWYGLFITSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIA
FILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAK
IVVFEAAKELNTNFRGIRSQFSIIVPLEHIDQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIH
HSYFSK
MVISNIRIGLFILAIIFVVLVFFYWRNEELYEEKKQRIRKTWYGLFITSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIA
FILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAK
IVVFEAAKELNTNFRGIRSQFSIIVPLEHIDQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIH
HSYFSK
Download Length: 741 bp
>T119167 NZ_CP036026:2379578-2380318 [Bacillus mycoides]
TTGGTAATCTCTAACATTCGAATCGGCTTATTTATTTTAGCGATCATTTTTGTAGTTCTTGTTTTTTTTTATTGGAGAAA
TGAAGAGTTATACGAAGAGAAAAAGCAGCGAATTCGAAAAACTTGGTATGGATTATTCATAACATCAGTCACAGTTTATT
TCATGATAAAAGGAATCGATTTAACCCTCTGGAAAAACTTATTAATGTTTACTGCGATGGTCATTTTCGTTGATATTGCA
TTTATTTTAACACCTAACATTTCAGAAATATGGGGAGCGAAATTTAGCGATATCGGCAAGACTGTTCAATCGATAAAACG
GTCATTAATTGCTTCAAAAGCAAGAGGAGAAATATACACAACAATTATTCAAAATGTCAATCCAGCAGTATTCGGTACAA
TGGAATGGCATACGGAAGAAGAATATACAAAAAGCTTAAACGCATTTTTAGATTCGTATGGGGAAAAGATTGGTGCGAAA
ATTGTTGTATTTGAAGCGGCAAAGGAATTAAATACAAACTTTCGCGGTATCCGCTCGCAATTTAGTATTATTGTTCCGTT
AGAACACATTGATCAACTGAATGAGCAGAAAGCGGTGCAAGTAGAAAATGTCGGAATAATACCAGCAAAAATAGTGAGTG
ATGTTTTCATTGTTATTGATGGGAAGAAAAATAACCTGCAAGATCGGGATTTTGAAAATGTTTATAATTTAACAATACAT
CATAGTTATTTTAGTAAGTAG
TTGGTAATCTCTAACATTCGAATCGGCTTATTTATTTTAGCGATCATTTTTGTAGTTCTTGTTTTTTTTTATTGGAGAAA
TGAAGAGTTATACGAAGAGAAAAAGCAGCGAATTCGAAAAACTTGGTATGGATTATTCATAACATCAGTCACAGTTTATT
TCATGATAAAAGGAATCGATTTAACCCTCTGGAAAAACTTATTAATGTTTACTGCGATGGTCATTTTCGTTGATATTGCA
TTTATTTTAACACCTAACATTTCAGAAATATGGGGAGCGAAATTTAGCGATATCGGCAAGACTGTTCAATCGATAAAACG
GTCATTAATTGCTTCAAAAGCAAGAGGAGAAATATACACAACAATTATTCAAAATGTCAATCCAGCAGTATTCGGTACAA
TGGAATGGCATACGGAAGAAGAATATACAAAAAGCTTAAACGCATTTTTAGATTCGTATGGGGAAAAGATTGGTGCGAAA
ATTGTTGTATTTGAAGCGGCAAAGGAATTAAATACAAACTTTCGCGGTATCCGCTCGCAATTTAGTATTATTGTTCCGTT
AGAACACATTGATCAACTGAATGAGCAGAAAGCGGTGCAAGTAGAAAATGTCGGAATAATACCAGCAAAAATAGTGAGTG
ATGTTTTCATTGTTATTGATGGGAAGAAAAATAACCTGCAAGATCGGGATTTTGAAAATGTTTATAATTTAACAATACAT
CATAGTTATTTTAGTAAGTAG
Antitoxin
Download Length: 42 a.a. Molecular weight: 4938.34 Da Isoelectric Point: 3.9150
>AT119167 WP_000588712.1 NZ_CP036026:2380426-2380551 [Bacillus mycoides]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK
Download Length: 126 bp
>AT119167 NZ_CP036026:2380426-2380551 [Bacillus mycoides]
GTGATAAAAGATTATGACAATGATTTTTTTAAAGAAGACAATGAAGATACAACAGATTTCTCTTTAATAAAAGGAGATAC
ATTACAGCAAGTAGAAGAATTAGAAGAAGAGCTAAAAAGAAAATGA
GTGATAAAAGATTATGACAATGATTTTTTTAAAGAAGACAATGAAGATACAACAGATTTCTCTTTAATAAAAGGAGATAC
ATTACAGCAAGTAGAAGAATTAGAAGAAGAGCTAAAAAGAAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|